The Cardiac Lymphatics

Bradham, R. Randolph; Parker, Edward F.; Barrington, B A; Webb, C M; Stallworth, J. Manly

doi:10.1097/00000658-197006010-00011

Cited by 35 publications

(26 citation statements)

References 2 publications

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“…Patek (1939) had used India ink to demonstrate the lymphatic capillaries in the subendocardial area and the myocardium, while Drinker et al (1940) investigated the flow, pressure, and composition of the cardiac lymph by cannulating a single lymphatic trunk. It was Bradham et al (1970), nonetheless, who confirmed the presence of lymphatic channels throughout the myocardium of the ventricles, particularly on the left side, in their studies of mongrel dogs (Fig. 2).…”

Section: Historymentioning

confidence: 73%

“…Patek gave credit to Rudbeck for the first investigation of the cardiac lymphatic system, identifying him as a researcher who, in 1653, documented observations of a few subepicardial lymphatics in the heart of a dog (Patek,1939). Years later, Nuck, according to Bradham et al (1970), demonstrated that the cardiac lymphatics could be injected directly with mercury. Patek (1939) had used India ink to demonstrate the lymphatic capillaries in the subendocardial area and the myocardium, while Drinker et al (1940) investigated the flow, pressure, and composition of the cardiac lymph by cannulating a single lymphatic trunk.…”

Section: Historymentioning

confidence: 99%

“… Surface lymphatics filled with India ink following injection of the ink into the myocardium at the apex of the left ventricle. (Reproduced with permission from Bradham et al, Ann Surg,1970, 171:899–902). [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]…”

Section: Historymentioning

confidence: 99%

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The cardiac lymphatic system

et al. 2011

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The lymphatic system, a network of vessels carrying clear interstitial fluid called lymph, is found throughout the human body. The system maintains homeostasis, receiving proteins and excess fluid from the interstitial tissues, and returning them to the venous system. Understanding of lymphatic drainage remains important in the diagnosis, prognosis, and treatment of diseases, including the metastasis of malignant diseases. Information specific to the cardiac lymphatics is scarce. Indeed, quite often the topic is not even mentioned in many medical textbooks. The goal of our review is to compile and analyze the information currently available concerning the cardiac lymphatics, hoping further to demonstrate the clinical importance of this neglected system.

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Section: Historymentioning

confidence: 73%

Section: Historymentioning

confidence: 99%

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The cardiac lymphatic system

et al. 2011

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“…126,127 It has long been assumed that cardiac lymph flow depends only on external systolic compressive forces. Diastolic lymph flow might involve active lymphatic contraction, as cardiac lymph flow is maintained during conditions where cardiac contractility is impaired.…”

Section: -125mentioning

confidence: 99%

“…128,129 This is consistent with forms of lymph propulsion that are independent of cardiac contraction. 126,128,[130][131][132] It is also possible that impaired cardiac lymph flow can participate in several forms of cardiac pathology, such as dilated cardiomyopathy (DCM) and heart failure. 127,133,134 Inflammatory myocarditis provokes myocardial edema, and formation of inflammatory infiltrates of lymphocytes and macrophages; both can drive underlying lymphatic pumping disturbances.…”

Section: -125mentioning

confidence: 99%

Anatomy and roles of lymphatics in inflammatory diseases

Al‐Kofahi

Yun

Minagar

et al. 2017

Clinical & Exp Neuroim

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The lymphatic system maintains tissue homeostasis by transporting interstitial fluid, lipids and debris from tissues to the main circulation, and delivers antigen and antigen presenting cells to local lymph nodes where they elicit immune responses. During inflammation, lymph flow increases to limit edema and prevents tissue antigen-presenting cell transport. Lymphatics also adjust their contractile activity to increase fluid transfer during acute inflammation. Conversely, chronic inflammation can provoke lymphostasis, which might limit pathogen spread within the circulation; however, decreased lymph flow leads to the persistence of immune cells and mediators in tissues to intensifying injury. Here, we review lymphatic structure function within the gut, heart and central nervous system, discussing potential roles of these lymphatics in the etiology of inflammatory bowel disease, myocarditis and neurovascular disease, and as novel targets for therapeutic management of several disease states.

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Lymphatics of the Atrioventricular Valves

Bradham¹

1973

Arch Surg

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The Cardiac Lymphatics

Cited by 35 publications

References 2 publications

The cardiac lymphatic system

The cardiac lymphatic system

Anatomy and roles of lymphatics in inflammatory diseases

Lymphatics of the Atrioventricular Valves

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