The Cardiac Effects of Prolonged Vitamin B12 and Folate Deficiency in Rats

Taban-Shomal, Omid; Kilter, Heiko; Wagner, Alexandra; Schorr, Heike; Umanskaya, Natalia; Hübner, Ulrich; Böhm, Michael; Herrmann, Wolfgang; Herrmann, Markus

doi:10.1007/s12012-009-9038-2

Cited by 13 publications

(9 citation statements)

References 30 publications

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“…First, nutrients act as a source of methyl groups or as co-enzymes for one-carbon metabolism that regulates methyl transfer (6) . B-vitamins including folate, vitamin B 12 , vitamin B 6 and vitamin B 2 are involved as coenzymes with methionine, choline, betaine and serine as methyl donors for DNA methylation and histone methylation (7) . Second, nutrients and bioactive food components can directly affect enzymes that catalyse DNA methylation and histone modifications (4) .…”

Section: Proceedings Of the Nutrition Societymentioning

confidence: 99%

Nutritional influences on epigenetics and age-related disease

2011

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Nutritional epigenetics has emerged as a novel mechanism underlying gene-diet interactions, further elucidating the modulatory role of nutrition in aging and age-related disease development. Epigenetics is defined as a heritable modification to the DNA that regulates chromosome architecture and modulates gene expression without changes in the underlying bp sequence, ultimately determining phenotype from genotype. DNA methylation and post-translational histone modifications are classical levels of epigenetic regulation. Epigenetic phenomena are critical from embryonic development through the aging process, with aberrations in epigenetic patterns emerging as aetiological mechanisms in many age-related diseases such as cancer, CVD and neurodegenerative disorders. Nutrients can act as the source of epigenetic modifications and can regulate the placement of these modifications. Nutrients involved in one-carbon metabolism, namely folate, vitamin B12, vitamin B6, riboflavin, methionine, choline and betaine, are involved in DNA methylation by regulating levels of the universal methyl donor S-adenosylmethionine and methyltransferase inhibitor S-adenosylhomocysteine. Other nutrients and bioactive food components such as retinoic acid, resveratrol, curcumin, sulforaphane and tea polyphenols can modulate epigenetic patterns by altering the levels of S-adenosylmethionine and S-adenosylhomocysteine or directing the enzymes that catalyse DNA methylation and histone modifications. Aging and age-related diseases are associated with profound changes in epigenetic patterns, though it is not yet known whether these changes are programmatic or stochastic in nature. Future work in this field seeks to characterise the epigenetic pattern of healthy aging to ultimately identify nutritional measures to achieve this pattern.

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Section: Proceedings Of the Nutrition Societymentioning

confidence: 99%

Nutritional influences on epigenetics and age-related disease

2011

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“… 40 , 41 Vitamin B12 deficiency will also result in HHcy because re-methylating Hcy to methionine is reduced, cannot transfer, which influences the production of methionine and regeneration of tetrahydro-folic acid. 42 …”

Section: Discussionmentioning

confidence: 99%

Hyperhomocysteinemia as a metabolic disorder parameter is independently associated with the severity of coronary heart disease

Liu

Yang

Peng

et al. 2015

SMJ

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Objectives:To study the associations between hyperhomocysteinemia (HHcy) and the severity of coronary heart disease (CHD).Methods:We retrospectively analyzed metabolic parameters, anthropometric variables, and life style habits in 292 CHD patients of different categories, and 100 controlled non-CHD patients with chest pain symptoms who were hospitalized in the Department of Cardiovascular Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, China between October 2013 and September 2014.Results:The prevalence of HHcy in CHD patients was 79.1%, while only 5% of non-CHD patients had elevated serum homocysteine (Hcy) concentrations. The prevalence of HHcy significantly increased from 5% in non-CHD controls to 66% in the stable angina pectoris (SAP) group, to 81.9% in the unstable angina pectoris group, and to 93.15% in the acute myocardial infarction (AMI) group (p<0.001). After adjusting for confounding factors, multivariate logistic regression analysis showed that HHcy was independently associated with CHD category (AMI versus SAP, odds ratio [6.38], 95% confidence interval; 1.18-34.46). The Hcy was negatively correlated with folic acid (r=-0.67, p<0.001) and vitamin B12 (r=-0.56, p<0.001). Of the CHD patients with HHcy, 51.1% had low folic acid and 42% had low vitamin B12, 7 or 5 times higher than that of CHD patients with normal-low Hcy concentrations (p<0.001).Conclusion:Hyperhomocysteinemia is independently associated with the severity of CHD, and significantly correlated with low status of folic acid and vitamin B12 in CHD patients.

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“…Several studies have been reported on the impact of vitamin B12 on cardiovascular system. Taban-Shomal et al [23] studied "the cardiac effects of prolonged vitamin B12 and folate deficiency in rats". They found that fractional shortening, LV dimension at end-diastole and end-systole, posterior wall thickness, perivascular collagen, mast cell number, and natriuretic peptide tissue levels were comparable in vitamin deficiency and control animals.…”

Section: Discussionmentioning

confidence: 99%