The carcinogenicity of β-propiolactone and 4-nitroquinoline N-oxide for the skin of the guinea-pig.

Parish, D. J.; Searle, C. E.

doi:10.1038/bjc.1966.23

Cited by 20 publications

(2 citation statements)

References 10 publications

(6 reference statements)

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“…F-Propiolacton erwies sich an der Haut von Ratten [10,11,27,28], Mäusen [4,10,25,[28][29][30][31][32], Meerschweinchen [33] und Goldhamstern [34] als ein potentes Carcinogen. Es entstanden vorwiegend fibroblastische Tumoren mit kollagenen Anteilen, histologisch als Spindelzell-, Fibro-oder Myxosarkom zu differenzieren.…”

Section: Carcinogene Wirkungunclassified

β‐Propiolacton [MAK Value Documentation in German language, 2004]

2012

The MAK‐Collection for Occupational Health and Safety

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Section: Carcinogene Wirkungunclassified

β‐Propiolacton [MAK Value Documentation in German language, 2004]

2012

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“…BPL has been used in organic synthesis for numerous purposes and has been shown to be carcinogenic in guinea pigs and mice by both skin painting and sc injection (4)(5)(6)(7). PO produces carcinomas of the stomach by ig gavage (8) and sarcomas by sc injection (9,10).…”

mentioning

confidence: 99%

Inhalation Carcinogenesis of Various Alkylating Agents<xref ref-type="fn" rid="FN2">2</xref>

1987

JNCI: Journal of the National Cancer Institute

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A series of earlier studies showed that inhalation exposures of rats to three water-reactive electrophilic compounds produced brisk yields of nasal cancer even when the animals were exposed for only 30 days (6 hr/dayX5 day/wk). In addition, carcinogenic potencies of the compounds appeared to relate to their chemical reactivities as measured by hydrolysis rates. For a further study of this phenomenon, inhalation exposures were conducted with five additional water-reactive compounds: J3-propiolactone [(BPL) CAS: 57-57-8), methylmethane sulfonate [(MMS) CAS: 66-27-3), ethylchloroformate [(ECF) CAS: 541-41-3), dichloroacetyl chloride [(DCAC) CAS: 79-36-7), and propylene oxide [(PO) CAS: 75-56-9) on male Sprague-Dawley rats. The hydrolysis rates of these compounds span 6 orders of magnitude. The compounds were administered for 30 days (6 hr/dayX5 days/wk) with the use of exposure concentrations that were inversely proportional to the respective hydrolysis rates. With this protocol, all compounds except PO (the slowest reacting compound) produced nasal cancer in rats. The concentrations of MMS and BPL employed in the studies produced similar nasal cancer yields, indicating that the carcinogenic potencies of these compounds in rat nasal mucosa were proportional to their hydrolysis rates. The nasal cancer yields of DCAC and ECF were less than expected. DCAC hydrolyzes so rapidly at in vivo temperatures (half-life «0.01 min) that it may not reach target DNA in reactive form. Why the exposures to ECF produced yields of nasal cancer not predicted by its reactivity is currently under investigation. These results combined with our earlier results demonstrate that the carcinogenic potencies of some inhaled reactive electrophilic compounds are related to their hydrolysis rates.-JNCI 1987; 79:285-289.

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β‐Propiolacton [MAK Value Documentation in German language, 1977]

2012

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 5. Lieferung, Ausgabe 1977 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Erfahrungen beim Menschen Tierexperimentelle Befunde Carcinogene Wirkung Carcinogene Wirkung von BPL nach wiederholter subkutaner Zufuhr Tumoren nach Hautpinselung mit β‐Propiolacton Zur Frage eines MAK‐Wertes

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The carcinogenicity of β-propiolactone and 4-nitroquinoline N-oxide for the skin of the guinea-pig.

Abstract: Images Figs. 1-4 Figs. 5-8 Figs. 9-12

Cited by 20 publications

References 10 publications

β‐Propiolacton [MAK Value Documentation in German language, 2004]

β‐Propiolacton [MAK Value Documentation in German language, 2004]

Inhalation Carcinogenesis of Various Alkylating Agents<xref ref-type="fn" rid="FN2">2</xref>

β‐Propiolacton [MAK Value Documentation in German language, 1977]

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