The Carcinogenic Effects of Formaldehyde Occupational Exposure: A Systematic Review

Protano, Carmela; Buomprisco, Giuseppe; Cammalleri, Vittoria; Pocino, Roberta Noemi; Marotta, Daniela; Simonazzi, S; Cardoni, F; Petyx, Marta; Iavicoli, Sergio; Vitali, Matteo

doi:10.3390/cancers14010165

Cited by 64 publications

(30 citation statements)

References 68 publications

(87 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At the same time, it can also inhibit tumor invasion, migration, and angiogenesis by regulating miRNA or AMPK/mTOR and other signaling pathways [ 74 , 75 ], and induce cancer cell apoptosis and protective autophagy[ 76 ]. Formaldehyde is a typical risk factor, which can cause oxidative damage, inflammation, and genotoxicity, and greatly increase the risk of cancer [ 77 , 78 ]. Future studies will be necessary to investigate these rich compounds in the context of OSCC and PD association.…”

Section: Discussionmentioning

confidence: 99%

Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma

Wen

et al. 2023

BMC Oral Health

View full text Add to dashboard Cite

Background Oral squamous cell carcinoma (OSCC) is one of the malignant tumors with a poor prognosis. Periodontitis (PD is considered a high-risk factor for OSCC, but the genetic mechanism is rarely studied. This study aims to link OSCC and PD by identifying common differentially expressed miRNAs (Co-DEmiRNAs), their related genes (Hub genes), transcription factors (TFs), signaling pathways, enrichment functions, and compounds, and searching for genetic commonalities. Methods The miRNAs expression datasets of OSCC and PD were searched from the GEO database. The miRNA and related crosstalk mechanism between OSCC and PD was obtained through a series of analyses. Results hsa-mir-497, hsa-mir-224, hsa-mir-210, hsa-mir-29c, hsa-mir-486-5p, and hsa-mir-31are the top miRNA nodes in Co-DEmiRNA-Target networks. The most significant candidate miRNA dysregulation genes are ZNF460, FBN1, CDK6, BTG2, and CBX6, while the most important dysregulation TF includes HIF1A, TP53, E2F1, MYCN, and JUN. 5-fluorouracil, Ginsenoside, Rh2, and Formaldehyde are the most correlated compounds. Enrichment analysis revealed cancer-related pathways and so on. Conclusions The comprehensive analysis reveals the interacting genetic and molecular mechanism between OSCC and PD, linking both and providing a foundation for future basic and clinical research.

show abstract

Section: Discussionmentioning

confidence: 99%

Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma

Wen

et al. 2023

BMC Oral Health

View full text Add to dashboard Cite

show abstract

“…For one thing, the DALYs and death rates of leukemia will increase with age, so the DALYs and death rates of the elderly will be higher than that of young adults. For another, if the elderly were exposed to toxic and harmful substances such as formaldehyde and benzene during adolescence, these substances will not immediately cause reactions after exposure but will slowly accumulate in the body, and symptoms will slowly emerge with age ( 46 , 47 ). Our findings call for an urgent need to accelerate efforts to reduce leukemia attributable to the occupational risk burden in elderly people.…”

Section: Discussionmentioning

confidence: 99%

Global disease burden and trends of leukemia attributable to occupational risk from 1990 to 2019: An observational trend study

Shi

Chen

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

BackgroundLeukemia caused by occupational risk is a problem that needs more attention and remains to be solved urgently, especially for acute lymphoid leukemia (ALL), acute myeloid leukemia (AML), and chronic lymphoid leukemia (CLL). However, there is a paucity of literature on this issue. We aimed to assess the global burden and trends of leukemia attributable to occupational risk from 1990 to 2019.MethodsThis observational trend study was based on the Global Burden of Disease (GBD) 2019 database, the global deaths, and disability-adjusted life years (DALYs), which were calculated to quantify the changing trend of leukemia attributable to occupational risk, were analyzed by age, year, geographical location, and socio-demographic index (SDI), and the corresponding estimated annual percentage change (EAPC) values were calculated.ResultsGlobal age-standardized DALYs and death rates of leukemia attributable to occupational risk presented significantly decline trends with EAPC [−0.38% (95% CI: −0.58 to −0.18%) for DALYs and −0.30% (95% CI: −0.45 to −0.146%) for death]. However, it was significantly increased in people aged 65–69 years [0.42% (95% CI: 0.30–0.55%) for DALYs and 0.38% (95% CI: 0.26–0.51%) for death]. At the same time, the age-standardized DALYs and death rates of ALL, AML, and CLL were presented a significantly increased trend with EAPCs [0.78% (95% CI: 0.65–0.91%), 0.87% (95% CI: 0.81–0.93%), and 0.66% (95% CI: 0.51–0.81%) for DALYs, respectively, and 0.75% (95% CI: 0.68–0.82%), 0.96% (95% CI: 0.91–1.01%), and 0.55% (95% CI: 0.43–0.68%) for death], respectively. The ALL, AML, and CLL were shown an upward trend in almost all age groups.ConclusionWe observed a substantial reduction in leukemia due to occupational risks between 1990 and 2019. However, the people aged 65–69 years and burdens of ALL, AML, and CLL had a significantly increased trend in almost all age groups. Thus, there remains an urgent need to accelerate efforts to reduce leukemia attributable to occupational risk-related death burden in this population and specific causes.

show abstract

“… 4 , 5 There have been instances such as in Japan 6 and India 7 where exposure had been reported to be above the accepted values, and with possible potential hazards ranging from the relatively mild ones such as irritation of the eyes and the skin to the relatively serious and severe effects such as cancer [Protano et al, 2021]. 8 Other chemical substances in the embalmment fluid could also have deleterious effects when exposure is above certain thresholds.…”

Section: Health Hazards That Dissector and Prosectors Are Exposed Tomentioning

confidence: 99%

A Need to Protect the Health and Rights of Anatomists Working in Dissection Laboratories

Owolabi¹,

Tijani²,

Ihunwo³

2022

RMHP

View full text Add to dashboard Cite

Anatomy in the context of medical or health science often requires dissection. Anatomical dissection is the purposeful and procedural exploration of the human tissues and organs by physically cutting through defined body planes, regions, and organs to access, define and explore the structures in a manner that facilitates learning. Anatomical dissection is a basic requirement for anatomical and medical education. It is a requirement in certain other fields of health sciences as well. Unfortunately, in many instances, the prosector and dissector in the anatomy laboratories are not considered for the hazards to which they are exposed whether in their health plans or remuneration package. Dissectors, unlike conventional hospital laboratory workers are often considered routine workers or teaching assistants. This is the case, for example, in many African medical institutions. Administrators possibly presume that hazards are only associated with service laboratories in the hospital or teaching hospital departments. It would therefore serve the purpose of advocacy, education, and orientation to highlight the hazards that these individuals who serve as dissectors, prosectors and laboratory staff members are exposed to. This commentary highlights the nature and sources of risks that anatomists who dissect, prosect and work in anatomical laboratories are exposed to. It also highlights how the rights and health of anatomists who dissect can be protected with specific recommendations. Hence, the recommendations speak to policies and practices that are required to serve this purpose. After highlighting the major risks that anatomists who dissect might face, and the major causes of the risks, we wish to propose ways by which these could be addressed based on these key considerations: protect, prevent, and compensate. This is what we have also termed the PPC principle for protecting the health and professional rights of anatomists who dissect and work in anatomical laboratories.

show abstract

The Carcinogenic Effects of Formaldehyde Occupational Exposure: A Systematic Review

Cited by 64 publications

References 68 publications

Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma

Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma

Global disease burden and trends of leukemia attributable to occupational risk from 1990 to 2019: An observational trend study

A Need to Protect the Health and Rights of Anatomists Working in Dissection Laboratories

Contact Info

Product

Resources

About