The carcinogenic effect of human smegma: An experimental study.I. Preliminary report

Pratt-Thomas, H.R.; Heins, Henry C.; Latham, Eugene; Dennis, Edward J.; McIvers, Forde A.

doi:10.1002/1097-0142(195607/08)9:4<671::aid-cncr2820090408>3.0.co;2-o

Cited by 74 publications

(15 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several risk factors have been reported in the literature, such as poor genital hygiene, phimosis, venereal disease, smoking and association with human papilloma virus infection [2±7]. An important factor playing a protective role in the genesis of penis carcinoma is neonatal circumcision as encountered in Moslems and Jews [6,7]. Some authors do not agree with Clinical N-classi®cation (N0, N1 c versus N2, N3) 6.05** 0.03 *Surgery AERT better than primary RT; **N0, N1 better than N2, N3.…”

Section: Discussionmentioning

confidence: 99%

Radiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?

Zouhair

Coucke

Jeanneret

et al. 2001

European Journal of Cancer

View full text Add to dashboard Cite

To assess the prognostic factors and the outcome in patients with squamous-cell carcinoma of the penis, a retrospective review of 41 consecutive patients with non-metastatic invasive carcinoma of the penis, treated between 1962 and 1994, was performed. The median age was 59 years (range: 35±76 years). According to the International Union Against Cancer (UICC) 1997 classi®cation, there were 12 (29%) T1, 24 (59%) T2, 4 (10%) T3 and 1 TX (2%) tumours. The N-classi®cation was distributed as follows: 29 (71%) patients with N0, 8 (20%) with N1, 3 (7%) with N2 and 1 (2%) with N3. Forty-four per cent (n=18) of the patients underwent surgery: partial penectomy with (n=4) or without (n=12) lymph node dissection, or total penectomy with (n=1) or without (n=1) lymph node dissection. 23 patients were treated with radiation therapy alone, and all but 4 of the patients who were operated upon received postoperative radiation therapy (n=14). The median follow-up period was 70 months (range 20±331 months). In a median period of 12 months (range 5±139 months), 63% (n=26) of the patients relapsed (local in 18, locoregional in 2, regional in 3 and distant in 3). Local failure (stump in the operated patients, and the tumour bed in those treated with primary radiation therapy) was observed in 4 out of 16 (25%) patients treated with partial penectomy AEpostoperative radiotherapy versus 14 out of 23 (61%) treated with primary radiotherapy (P=0.06). 15 (83%) out of 18 local failures were successfully salvaged with surgery. In all patients, 5-and 10-year survival rates were 57% (95% con®dence interval (CI), 41±73%) and 38% (95% CI, 21± 55%), respectively. The 5-year local and locoregional rates were 57% (95% CI, 41±73%) and 48% (95% CI, 32±64%), respectively. In patients treated with primary radiotherapy, 5-and 10-year probabilities of surviving with penis preservation were 36% (95% CI, 22±50%) and 18% (95% CI, 2±34%), respectively. In multivariate analyses, survival was signi®cantly in¯uenced by the N-classi®-cation, and surgery was the only independent factor predicting the locoregional control. We conclude that, in patients with squamous-cell carcinoma of the penis, local control is better in patients treated with surgery. However, there seems to be no di erence in terms of survival between patients treated by surgery and those treated by primary radiotherapy AEsalvage surgery, with 39% having organ preservation. #

show abstract

Section: Discussionmentioning

confidence: 99%

Radiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?

Zouhair

Coucke

Jeanneret

et al. 2001

European Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…(43) The majority of infections are subclinical, and are more prevalent in uncircumcised men with balanoposthitis. (44) Smegma was implicated in an early study, (45) but such findings remain to be confirmed. (46) Consistent with HPV's sexual transmission, 93% of men whose female partner had a squamous intraepithelial lesion (SIL) had penile intra-epithelial neoplasia (PIN).…”

Section: Penile Cancermentioning

confidence: 98%

Why circumcision is a biomedical imperative for the 21^stcentury

Morris

2007

BioEssays

101

View full text Add to dashboard Cite

Circumcision of males represents a surgical “vaccine“ against a wide variety of infections, adverse medical conditions and potentially fatal diseases over their lifetime, and also protects their sexual partners. In experienced hands, this common, inexpensive procedure is very safe, can be pain‐free and can be performed at any age. The benefits vastly outweigh risks. The enormous public health benefits include protection from urinary tract infections, sexually transmitted HIV, HPV, syphilis and chancroid, penile and prostate cancer, phimosis, thrush, and inflammatory dermatoses. In women circumcision of the male partner provides substantial protection from cervical cancer and chlamydia. Circumcision has socio‐sexual benefits and reduces sexual problems with age. It has no adverse effect on penile sensitivity, function, or sensation during sexual arousal. Most women prefer the circumcised penis for appearance, hygiene and sex. Given the convincing epidemiological evidence and biological support, routine circumcision should be highly recommended by all health professionals. BioEssays 29:1147–1158, 2007. © 2007 Wiley Periodicals, Inc.

show abstract

“…1 Possible etiologies include human papilloma virus infection, phimosis, poor hygiene and cigarette smoking. [2][3][4][5] Several precancerous penile lesions have been associated with invasive squamous cell carcinoma, including Queyrat's erythroplasia. This is a carcinoma in situ of the glans penis, first described by Queyrat in 1911 as a red, velvety, slightly-raised lesion that is sometimes ulcerated and papillary.…”

Section: Discussionmentioning

confidence: 99%

A rare case of penile cancer in situ metastasizing to lymph nodes

Kim

Garcı́a

Touma

et al. 2013

CUAJ

View full text Add to dashboard Cite

show abstract

The carcinogenic effect of human smegma: An experimental study.I. Preliminary report

Cited by 74 publications

References 8 publications

Radiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?

Radiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?

Why circumcision is a biomedical imperative for the 21^stcentury

A rare case of penile cancer in situ metastasizing to lymph nodes

Contact Info

Product

Resources

About

The carcinogenic effect of human smegma: An experimental study.I. Preliminary report

Cited by 74 publications

References 8 publications

Radiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?

Radiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?

Why circumcision is a biomedical imperative for the 21stcentury

A rare case of penile cancer in situ metastasizing to lymph nodes

Contact Info

Product

Resources

About

Why circumcision is a biomedical imperative for the 21^stcentury