The carboxyl‐terminal region of coagulation serine proteases: A matter of cut and change

Abstract

In this issue of Journal of Thrombosis and Haemostasis, Hayakawa et al. report on a novel factor XI (FXI) variant, associated with FXI deficiency, caused by the homozygous F11 c.1788dupC mutation. This duplication results in the p.Glu597Argfs*65 frameshift variant, which produces an FXI molecule aberrantly elongated at the carboxyl-terminal region. 1The "carboxyl-terminal history" has begun with the work pub-