The carbon dioxide production rate assumption biases gastric emptying parameters in healthy adults

Abstract

The findings highlight the importance of directly measuring VCO(2)production rates throughout the (13)C OBT and could partly explain the conflicting evidence regarding the effect of obesity on GE rates.

The [13C]octanoic acid breath test for gastric emptying quantification: A focus on nutrition and modeling

“…Sanaka et al (2008) studied the detailed kinetics involved in GE of [ 13 C]octanoic acid once ingested in a test meal, which was important for the validation of the discrepancy in the results of the model by Ghoos et al (1993). Further research (Markey & Shafat, 2013) investigated different mechanisms to determine the CO 2 production rate (VCO 2 ) from the breath and the subsequent impact on GE results. They developed new parameters for the study with VCO 2DM the direct measurement of rate, VCO 2PR the predicted rate from resting and VCO 2BSA the predicted rate from body surface area.…”

“…Further research (Markey & Shafat, 2013) investigated different mechanisms to determine the CO 2 production rate (VCO 2 ) from the breath and the subsequent impact on GE results. They developed new parameters for the study with VCO 2DM the direct measurement of rate, VCO 2PR the predicted rate from resting and VCO 2BSA the predicted rate from body surface area.…”