The captopril test in children with renovascular and renal hypertension

Fossali, Emilio F.; Intermite, R.; Minoja, M; Tirelli, Silvia; Sereni, F

doi:10.1111/j.1651-2227.1996.tb14232.x

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…A captopril test may also be useful, even in children [31]. In our series the captopril test was positive in the majority of patients from group II.…”

Section: Discussionmentioning

confidence: 69%

Renovascular disease and hypertension in children with neurofibromatosis

Fossali

Signorini

Intermite

et al. 2000

Pediatric Nephrology

114

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Neurofibromatosis type 1 (NF1) is associated with vascular lesions, such as renal artery stenosis, and secondary hypertension. The real prevalence is largely unknown, particularly in children. We observed 27 patients with NF1, mean age 12.8 years (range 4.2-24 years), for 2-10 years to assess the association of NF1 with vascular abnormalities and secondary hypertension. Patients were studied with angiography, 24-h blood pressure monitoring, a captopril test, and Doppler ultrasonography of aorta and renal arteries. The prevalence of hypertension was 18.5%; 61.5% of patients studied with angiography had vascular lesions, half of whom were apparently normotensive. However, they had abnormal 24-h blood pressure monitoring, which was a first sign of poor blood pressure control. Those patients with severe hypertension (11.1%) were successfully treated with percutaneous transluminal angioplasty (PTA); stenosis recurred in 2 of 3 patients after a 2-year follow-up period, and was responsive to drugs. We conclude that hypertension is a frequent complication of NF1 in pediatric patients, it is usually secondary to typical vascular lesions, and requires careful follow-up. Ambulatory blood pressure monitoring (24-h) is a sensitive method for detecting initial alterations of the blood pressure pattern. PTA may be an effective treatment in this condition.

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“…A captopril test may also be useful, even in children [31]. In our series the captopril test was positive in the majority of patients from group II.…”

Section: Discussionmentioning

confidence: 69%

Renovascular disease and hypertension in children with neurofibromatosis

Fossali

Signorini

Intermite

et al. 2000

Pediatric Nephrology

114

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“…Peripheral plasma renin activity (with or without captopril) is a useful screening test for both renovascular and renal parenchymal disease. 2 It should be remembered that normal values gradually decrease with age. A suppressed value suggests excess mineralocorticoid effect (hyperaldosteronism, Liddle syndrome), or apparent mineralocorticoid excess.…”

Section: Additional Tests Only As Indicatedmentioning

confidence: 99%

Assessment and Management of Hypertension in Children and Adolescents: Part B – Investigations and Management

Narchi

2011

JMS

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Once the diagnosis of hypertension has been established in a child or an adolescent, the investigations to be requested need to include a search for the primary cause when secondary hypertension is suspected, the identification of associated and co-morbid conditions and the evaluation of target-organ damage. Instituting therapy should be based on clear indications, the choice of lifestyle and/or pharmacological treatment should be guided by the pathophysiology of the underlying mechanism and based on evidence-based guidelines.

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The captopril test in children with renovascular and renal hypertension

Cited by 2 publications

References 5 publications

Renovascular disease and hypertension in children with neurofibromatosis

Renovascular disease and hypertension in children with neurofibromatosis

Assessment and Management of Hypertension in Children and Adolescents: Part B – Investigations and Management

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