The Capillary-Tube Method of Rhesus Testing

Discombe, George; Meyer, Hanne-Lys

doi:10.1093/ajcp/22.6.543

Cited by 28 publications

(10 citation statements)

References 8 publications

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“…The distribution of blood groups in our series of 11,086 cases differed significantly from those of Pike and Dickins ('954), Richardson (1954), and Discombe and Meyer (1952), although the latter three series were compiled in an area within a few miles of this hospital (Table 1). If our series is compared with that of Discombe and Meyer the x2 for three degrees of freedom is 18.68.…”

Section: Resultscontrasting

confidence: 56%

ABO Blood Groups and Toxaemia of Pregnancy

Pearson¹,

Pinker²

1956

BMJ

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Coombs test was carried out on infants' cells sensitized in mothers' serum. No other incompatibility was detected.So far as we are able to analyse the figures, the first period, as shown above, consistently yields a fairly highly significant excess of 0 in toxaemia, the second period equally consistently yielded no such excess. It may be that there is a phenomenon to explain, but on the present evidence it seems likely that the original finding was due to chance. This experience serves to emphasize the need for large numbers in work in this field, the desirability of demanding a high level of significance before results are taken as more than an indication for further inquiry, and also the desirability of comparing results from different hospitals and different areas. Summary A further series does not confirm the finding (Pike and Dickins, 1954) that there is an excess of women of group 0 among those suffering from toxaemia of pregnancy. In a study of 541 patients with toxaemia of pregnancy, Pike and Dickins (1954) found a significant excess of women of blood group 0 as compared with nontoxaemic pregnant women. It was suggested that some of the features of toxaemia might be the result of an antigen-antibody reaction. We thought it would be of interest to repeat their investigation on a similar series of patients admitted to another hospital. MaterialThe investigation was carried out on 11,086 consecutive admissions to the maternity department of Hammersmith Hospital between 1949 and 1954.The majority of patients, both primigravidae and multiparae, are booked for delivery at this hospital in order of their application for admission at the antenatal clinic. Patients attending for the first time in late pregnancy are admitted on obstetrical, medical, or social grounds only.For the purposes of this investigation and in order to conform with the criteria selected by Pike and Dickins, patients were regarded as having toxaemia of pregnancy if they showed two of the following signs: (1) a blood pressure of 140/90 or over after the 28th week of pregnancy; (2) clinical oedema or an average weight gain of more than 2 lb. (0.9 kg.) a week from the 28th week; (3) albuminuria in a catheter specimen, not due to infection. The level of weight gain which we regarded as significant in the absence of clinical oedema was greater than that selected by Pike and Dickins, but otherwise our criteria were identical wvith theirs. Results

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Section: Resultscontrasting

confidence: 56%

ABO Blood Groups and Toxaemia of Pregnancy

Pearson¹,

Pinker²

1956

BMJ

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“…The results are closely similar in the two groups and they have, therefore, been combined to provide a single control series. Table II shows the distribution of the ABO blood groups in the combined series as compared with that reported by Discombe and Meyer (1952) for 10,000 women attending ante-natal clinics in the area of the Central Middlesex Hospital. The two sets of results are almost identical.…”

Section: Resultsmentioning

confidence: 98%

Secretion of blood group substances in duodenal, gastric and stomal ulcer, gastric carcinoma, and diabetes mellitus

Doll¹,

Drane²,

Newell³

1961

Gut

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For both types of ulcer, the estimated risk among non-secretors was similar for blood group 0 and for the other blood groups and the results suggest that the specific risks associated with blood group 0 and with non-secretion multiply one another. It is concluded that the mechanisms by which blood group 0 and non-secretion affect the risk of developing a gastric or duodenal ulcer are related to one another; but that they do not depend on the presence of the blood group substances in the secretions.The proportion of non-secretors among patients with a stomal ulcer (49 %) was higher than among patients with a duodenal ulcer (37 %) and the order of the relationship between non-secretion and the three types of peptic ulcer (stomal, duodenal, and gastric) was the same as that for blood group 0.Other data suggest that there may be a slight increase in the risk of gastric cancer among nonsecretors, but that the occurrence of diabetes mellitus is independent of ABH secretion.Interest in the association between gastrointestinal disease and the ABO blood group substances was enhanced by the discovery that there was also an association between duodenal ulcer and failure to secrete the substances in the mucous secretions

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“…Tables of observed and expected numbers were, therefore, constructed which enabled a comparison to be made between the observed proportions of patients belonging to groups 0 and A in each category of each variable and the numbers that would be expected after adjusting for the effect of the other variables. In fact, none of the four variables introduced much bias into the association between the other variables and the blood groups and so only the uncorrected expectations are given in Tables III, IV, and V. Two sets of data were used for controls: blood group data on 10,000 pregnant women attending the antenatal clinic of the Central Middlesex Hospital during the years 1947-1951 (Discombe and Meyer, 1952) and on 33,062 blood donors of both sexes, resident in London, and aged 18-60 years, which were collected during 1952-1960(Kopec, 1970. The percentage distributions of the ABO groups in these two control series were identical to one decimal place, and the series were, therefore, combined.…”

Section: Methodsmentioning

confidence: 99%

Interaction between ABO and Rhesus blood groups, the site of origin of gastric cancers, and the age and sex of the patient

Glober¹,

Cantrell²,

Doll³

et al. 1971

Gut

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SUMMARY ABO and Rhesus blood group data have been examined for 1,680 patients treated for gastric cancer in four London hospitals.The risk of developing gastric cancer was estimated to be 16% higher for group A subjects than for group 0 subjects, in close agreement with many previous reports throughout the world. More detailed analysis failed to support the suggestion that there was any special correlation between either ABO or Rhesus blood groups and the site of origin of the tumour within the stomach or the sex or age of the patient.Male predominance among the patients was noted to be greater at ages 40-69 years than at other ages and greater for tumours of the upper two thirds of the stomach than for tumours that arose distally.The relevance of genetic factors to the aetiology of gastric carcinoma is widely accepted and is derived from familial and blood group studies (McConnell, 1966). The precise contribution of these genetic factors, however, is unknown. Aird, Bentall, and Roberts (1953) were the first to study ABO blood groups in a large number of patients with gastric cancer and found an excess of group A and a deficiency of group 0 in comparison with control patients. Subsequently, at least 71 controlled series have been published; in 55 of these the cancer patients showed an excess of group A, in 14 a slight predominance of group A, and in only two a deficiency of group A (McConnell, 1966). These world-wide studies show that group A increases the risk of gastric malignancy by about 20 %, and that this proportional increase is approximately the same irrespective of whether the overall incidence is low, intermediate, or high.To define more exactly the contribution of this genetic effect to the pathogenesis of gastric cancer, workers have examined blood groups in relation to such variables as tumour site, histology, gastric acidity, and age and sex of the patient. Among these studies was that of Doll, Swynnerton, and Newell (1960) who found a decreasing ratio of group A to

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The Capillary-Tube Method of Rhesus Testing

Cited by 28 publications

References 8 publications

ABO Blood Groups and Toxaemia of Pregnancy

ABO Blood Groups and Toxaemia of Pregnancy

Secretion of blood group substances in duodenal, gastric and stomal ulcer, gastric carcinoma, and diabetes mellitus

Interaction between ABO and Rhesus blood groups, the site of origin of gastric cancers, and the age and sex of the patient

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