2013
DOI: 10.1002/eji.201242938
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The capacity of Th2 lymphocytes to deliver B‐cell help requires expression of the transcription factor STAT3

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Cited by 25 publications
(19 citation statements)
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References 50 publications
(69 reference statements)
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“…Indeed, Th17 cells, which are decreased by UA treatment, are known to play a role in antibody production [3] . These results are consistent with other known functions of STAT3, including the generation of follicular helper T cells [30] and development of Th2-mediated B cells [31] . Taken together, it is clear that UA ameliorates autoimmune arthritis by targeting multiple processes associated with STAT3 activation.…”
Section: Discussionsupporting
confidence: 91%
“…Indeed, Th17 cells, which are decreased by UA treatment, are known to play a role in antibody production [3] . These results are consistent with other known functions of STAT3, including the generation of follicular helper T cells [30] and development of Th2-mediated B cells [31] . Taken together, it is clear that UA ameliorates autoimmune arthritis by targeting multiple processes associated with STAT3 activation.…”
Section: Discussionsupporting
confidence: 91%
“…CD62L hi CD4 + T cells and B cells were purified from naive animals by magnetic separation, as previously described (16, 17). The percentage of purified cell fractions in all experiments ranged between 90 and 98%, as estimated by flow cytometry (data not shown).…”
Section: Methodsmentioning
confidence: 99%
“…Although the activation of STAT3 was first described in Th1 lymphocytes (44), increasing evidence suggests that this pathway plays a major role in Th2 lymphocyte differentiation (45)(46)(47). The Wnt/b-catenin pathway also stimulates Th2 differentiation, as well as IL-4 and IL-13 production, in human CD4 + T cells in a mouse model of allergic asthma (48,49).…”
Section: Discussionmentioning
confidence: 99%