The capacity of neural crest‐derived stem cells for ocular repair

Liu, Bo; Hunter, Daniel J.; Smith, Andrew A.; Chen, Serafine; Helms, Jill A.

doi:10.1002/bdrc.21077

Cited by 11 publications

(13 citation statements)

References 91 publications

(108 reference statements)

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“…Although Müller cells share a lineage with retinal neurons, their time of birth appears to be different. Recent studies found the surprising origin of Müller cells in the neuronal crest cells (Liu et al, 2014a). Birth dating of retinal neurons and Müller cells was determined by 3 H-thymidinelabelling (Sidman, 1961) and all retinal cell types are generated in an orderly fashion, the sequence of which is largely conserved among vertebrates (Vecino and Acera, 2015).…”

Section: Origin and Morphology Of Müller Cellsmentioning

confidence: 99%

Glia–neuron interactions in the mammalian retina

Vecino

Rodríguez

Ruzafa

et al. 2016

Progress in Retinal and Eye Research

609

533

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The mammalian retina provides an excellent opportunity to study glia-neuron interactions and the interactions of glia with blood vessels. Three main types of glial cells are found in the mammalian retina that serve to maintain retinal homeostasis: astrocytes, Müller cells and resident microglia. Müller cells, astrocytes and microglia not only provide structural support but they are also involved in metabolism, the phagocytosis of neuronal debris, the release of certain transmitters and trophic factors and K(+) uptake. Astrocytes are mostly located in the nerve fibre layer and they accompany the blood vessels in the inner nuclear layer. Indeed, like Müller cells, astrocytic processes cover the blood vessels forming the retinal blood barrier and they fulfil a significant role in ion homeostasis. Among other activities, microglia can be stimulated to fulfil a macrophage function, as well as to interact with other glial cells and neurons by secreting growth factors. This review summarizes the main functional relationships between retinal glial cells and neurons, presenting a general picture of the retina recently modified based on experimental observations. The preferential involvement of the distinct glia cells in terms of the activity in the retina is discussed, for example, while Müller cells may serve as progenitors of retinal neurons, astrocytes and microglia are responsible for synaptic pruning. Since different types of glia participate together in certain activities in the retina, it is imperative to explore the order of redundancy and to explore the heterogeneity among these cells. Recent studies revealed the association of glia cell heterogeneity with specific functions. Finally, the neuroprotective effects of glia on photoreceptors and ganglion cells under normal and adverse conditions will also be explored.

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Section: Origin and Morphology Of Müller Cellsmentioning

confidence: 99%

Glia–neuron interactions in the mammalian retina

Vecino

Rodríguez

Ruzafa

et al. 2016

Progress in Retinal and Eye Research

609

533

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“…Hence, autologous HFBSCs are potentially suitable for therapeutic application in a broad range of neurological disorders such as ALS, Alzheimer’s disease and stroke. They also may be used in cell-based therapies for sensory neurological diseases such as those for ocular or inner ear regeneration (Liu et al 2014 ; Huisman and Rivolta 2012 ). If HFBSCs could be harvested from plucked hairs, their practical utilization for autologous stem cell therapy would increase immensely.…”

Section: Introductionmentioning

confidence: 99%

Isolation, expansion and neural differentiation of stem cells from human plucked hair: a further step towards autologous nerve recovery

et al. 2015

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Stem cells from the adult hair follicle bulge can differentiate into neurons and glia, which is advantageous for the development of an autologous cell-based therapy for neurological diseases. Consequently, bulge stem cells from plucked hair may increase opportunities for personalized neuroregenerative therapy. Hairs were plucked from the scalps of healthy donors, and the bulges were cultured without prior tissue treatment. Shortly after outgrowth from the bulge, cellular protein expression was established immunohistochemically. The doubling time was calculated upon expansion, and the viability of expanded, cryopreserved cells was assessed after shear stress. The neuroglial differentiation potential was assessed from cryopreserved cells. Shortly after outgrowth, the cells were immunopositive for nestin, SLUG, AP-2α and SOX9, and negative for SOX10. Each bulge yielded approximately 1 × 104 cells after three passages. Doubling time was 3.3 (±1.5) days. Cellular viability did not differ significantly from control cells after shear stress. The cells expressed class III β-tubulin (TUBB3) and synapsin-1 after 3 weeks of neuronal differentiation. Glial differentiation yielded KROX20- and MPZ-immunopositive cells after 2 weeks. We demonstrated that human hair follicle bulge-derived stem cells can be cultivated easily, expanded efficiently and kept frozen until needed. After cryopreservation, the cells were viable and displayed both neuronal and glial differentiation potential.

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“…Of note, a recent lineage study in the mouse suggests that a subset of Müller cells may be derived from the neural crest (Liu et al, 2014). This is quite unexpected and thus clearly deserves further investigation and comparative studies in different vertebrate species.…”

Section: The Müller Cell: More Than Just a Glial Cellmentioning

confidence: 99%

“…As mentioned above, a recent study suggested that a subset of Müller cells in the mouse retina may derive from the neural crest (Liu et al, 2014). This is quite surprising and contrasts with results of most neural crest lineage tracing studies and with previous evidence that Müller glia is exclusively derived from the retinal neuroepithelium.…”

Section: Müller Cell Response To Injury In Mammalsmentioning

confidence: 99%

“…M€ uller cells are the only type of retinal glia that share a common embryonic origin with retinal neurons (Turner and Cepko, 1987;Holt et al, 1988;Wetts and Fraser, 1988). Of note, a recent lineage study in the mouse suggests that a subset of M€ uller cells may be derived from the neural crest (Liu et al, 2014). This is quite unexpected and thus clearly deserves further investigation and comparative studies in different vertebrate species.…”

Section: Introductionmentioning

confidence: 99%

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Müller glial cell‐dependent regeneration of the neural retina: An overview across vertebrate model systems

Hamon

Roger

Yang

et al. 2016

Developmental Dynamics

110

103

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Retinal dystrophies are a major cause of blindness for which there are currently no curative treatments. Transplantation of stem cell-derived neuronal progenitors to replace lost cells has been widely investigated as a therapeutic option. Another promising strategy would be to trigger self-repair mechanisms in patients, through the recruitment of endogenous cells with stemness properties. Accumulating evidence in the last 15 years has revealed that several retinal cell types possess neurogenic potential, thus opening new avenues for regenerative medicine. Among them, Müller glial cells have been shown to be able to undergo a reprogramming process to re-acquire a stem/progenitor state, allowing them to proliferate and generate new neurons for repair following retinal damages. Although Müller cell-dependent spontaneous regeneration is remarkable in some species such as the fish, it is extremely limited and ineffective in mammals. Understanding the cellular events and molecular mechanisms underlying Müller cell activities in species endowed with regenerative capacities could provide knowledge to unlock the restricted potential of their mammalian counterparts. In this context, the present review provides an overview of Müller cell responses to injury across vertebrate model systems and summarizes recent advances in this rapidly evolving field.

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The capacity of neural crest‐derived stem cells for ocular repair

Cited by 11 publications

References 91 publications

Glia–neuron interactions in the mammalian retina

Glia–neuron interactions in the mammalian retina

Isolation, expansion and neural differentiation of stem cells from human plucked hair: a further step towards autologous nerve recovery

Müller glial cell‐dependent regeneration of the neural retina: An overview across vertebrate model systems

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