The capacity for the de novo biosynthesis of creatine is present in the tunicate Ciona intestinalis and is likely widespread in other protochordate and invertebrate groups

DeLigio, James T.; Ellington, W. Ross

doi:10.1016/j.cbd.2005.08.006

Cited by 3 publications

(2 citation statements)

References 45 publications

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“…With the genomic sequencing project completed, AGAT, GAMT, and CT1 have been investigated in human (Isbrandt and von Figura 1995;Chae et al 1998), other diverse vertebrates such as rat Braissant et al 2005), mouse (Lee et al 1994;Torremans et al 2005), Xenopus (Zhao et al 2001), and zebrafish ) as well as invertebrate tunicate (Roche et al 1957;Robin 1964;Van Pilsum et al 1972;Van Pilsum et al 1975;DeLigio and Ellington 2006). So far, Cr biosynthesis and transport have been established, which are important to the physiology, human pathology, and clinical diagnosis (Wyss and Kaddurah-Daouk 2000;Ellington and Suzuki 2007).…”

Section: Introductionmentioning

confidence: 98%

“…So far, Cr biosynthesis and transport have been established, which are important to the physiology, human pathology, and clinical diagnosis (Wyss and Kaddurah-Daouk 2000;Ellington and Suzuki 2007). Creatine, phosphocreatine, and creatine kinase have been found widespread in invertebrate species (e.g., some annelids, echinoderms, hemichordates, and urochordates; Van Pilsum et al 1972;Wyss and Kaddurah-Daouk 2000;DeLigio and Ellington 2006) and the coevolution of creatine kinase and creatine biosynthesis/transport related molecules has been addressed by Ellington and Suzuki (Graber and Ellington 2001;Salomons and Wyss 2007). In order to understand the molecular mechanism of creatine synthesis and transport in protochordate and give some new clues for the evolution of creatine metabolism at the invertebrateto-vertebrate transition, we clone and identify AGAT, GAMT, and CT1 genes from a cephalochordate, amphioxus, a good model system for insights into the origin and evolution of vertebrates and also report the phylogenetic and genomic analysis as well as the expression patterns of AGAT, GAMT, and CT1 genes in amphioxus embryos and adults.…”

Section: Introductionmentioning

confidence: 98%

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Characterization of AGAT, GAMT and CT1 in amphioxus: implications for the evolutionary conservation of creatine metabolism related molecules at the invertebrate-to-vertebrate transition

et al. 2008

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In vertebrates, glycine amidinotransferase (AGAT), guanidinoacetate methyltransferase (GAMT), and creatine transporter (CT1) are three proteins involved in creatine synthesis. To provide insight into the molecular evolution mechanism of creatine metabolism, we have cloned and identified BbAGAT, BbGAMT, and BbCT1 homologous genes in amphioxus (Branchiostoma belcheri), whose predicted proteins show high identities with AGAT, GAMT, and CT1 proteins in vertebrates. The phylogenetic analysis indicates that amphioxus AGAT, GAMT, and CT1 are branched off at the base of the vertebrate homologous clade, respectively. Genomic structures of BfAGAT, BfGAMT, and BfCT1 show their comparability with the homologs in vertebrate and original characteristic of cephalochordate, which is consistent with animal classification. To determine the expression patterns of BbAGAT, BbGAMT, and BbCT1, whole-mount and section in situ hybridizations are carried out in embryos and adults of amphioxus. During embryogenesis, they are all expressed mainly in mesendoderm and late somites, but BbCT1 is also expressed in differentiating notochord and digestive tract, as well as in the cytoplasm of zygotes and the blastomeres at cleavage stage. In adult, the transcripts of BbAGAT and BbGAMT are detected in the neural cord, gill, nephridia, endostyle, gut, and gonads, while BbCT1 is expressed mainly in the epithelium of gut. The expression pattern of these three genes is similar to their vertebrate homologs. The result reveals that AGAT, GAMT, and CT1, the primary elements of vertebrate creatine metabolism, exist in cephalochordate amphioxus, and are highly conserved during evolution. It also suggests that similar mechanism of creatine synthesis in vertebrate may occur in amphioxus.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

Characterization of AGAT, GAMT and CT1 in amphioxus: implications for the evolutionary conservation of creatine metabolism related molecules at the invertebrate-to-vertebrate transition

et al. 2008

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Evolution of the diverse array of phosphagen systems present in annelids

Suzuki

Uda

Adachi

et al. 2009

Comparative Biochemistry and Physiology Part B: Biochemistry an

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Monitoring for propagules of Ciona intestinalis in marine water samples: the development of temporal gene expression markers for viability and life stage specific assays

Stewart-Clark¹,

Davidson²,

Greenwood³

2013

MBI

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We developed two risk models to investigate the movement of introduced marine species into High-value areas (HVAs), using Undaria pinnatifida invasions in New Zealand as a model system. This process focussed on the secondary transfer of Undaria into the HVAs, as it is already introduced to New Zealand. The first model was a qualitative, theoretical risk assessment based on expert opinion, and was used by management to re-assess the potential impacts of Undaria on values associated with a set of six, expert identified, HVAs. The risk reassessment process identified that Undaria posed an extreme risk to a majority of values in all evaluated HVAs. Based on this outcome, a realised risk assessment model was developed and is described that uses quantitative vessel and propagule strength data to examine secondary transfers of Undaria into HVAs. The realised risk assessment is the next stage in the process of delineating the risk Undaria poses to New Zealand HVAs. The intent of this process was to provide salient, credible and legitimate information to decision-makers in a transparent manner because direct impact data is limited and uncertain. Both models presented are readily applicable to Undaria invasions in different regions and countries, with the original re-assessment model having been used by biosecurity managers.

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The capacity for the de novo biosynthesis of creatine is present in the tunicate Ciona intestinalis and is likely widespread in other protochordate and invertebrate groups

Cited by 3 publications

References 45 publications

Characterization of AGAT, GAMT and CT1 in amphioxus: implications for the evolutionary conservation of creatine metabolism related molecules at the invertebrate-to-vertebrate transition

Characterization of AGAT, GAMT and CT1 in amphioxus: implications for the evolutionary conservation of creatine metabolism related molecules at the invertebrate-to-vertebrate transition

Evolution of the diverse array of phosphagen systems present in annelids

Monitoring for propagules of Ciona intestinalis in marine water samples: the development of temporal gene expression markers for viability and life stage specific assays

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