The CAP cancer protocols – a case study of caCORE based data standards implementation to integrate with the Cancer Biomedical Informatics Grid

Tobias, Jonathan; Chilukuri, Ram; Komatsoulis, George A.; Mohanty, Sambit K.; Sioutos, Nicholas; Warzel, Denise; Wright, Lawrence W.; Crowley, Rebecca S.

doi:10.1186/1472-6947-6-25

Cited by 33 publications

(25 citation statements)

References 9 publications

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“…The Cancer Biomedical Informatics Grid (caBIG), a network of individuals and institutions developing the future infrastructure of cancer biomedical informatics research, has proposed that the CAP cancer checklists for which the UPMC synoptics are based, be the electronic data standard in pathology. 13 Our study shows that our mission to provide synoptic templates that serve as a conduit for capturing and storing data in a virtual biorepository for translational research and clinically relevant information has been a success. …”

Section: Discussionmentioning

confidence: 99%

Utility and applications of synoptic reporting in pathology

Amin¹,

Sirintrapun²,

Parwani

2010

OAB

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Background: Synoptic reports in routine pathology practice provide composite documents that include information from morphology and molecular technologies. It is clear and accurate structured information and developed by incorporating standardized data elements in the form of checklist for pathology reporting. This facilitates pathologists to document their findings and ultimately improve the overall quality of pathology reports. Objectives: The goal of this review article is to discuss (1) the importance of synoptic reporting in pathology, (2) utility and applications, (3) its impact on pathology reporting and patient care, and (4) the challenges and barriers of implementing synoptic reporting. Pertinent literature will also be reviewed. Design: The synoptic reporting system provides a complete set of data elements in the form of synoptic templates or "worksheets" for pathology tumor reporting based on the World Health Organization (WHO) Classification and the College of American Pathologists (CAP) Cancer Checklists. These standards provide most updated and supplemented classification scheme, specimen details, and staging as well as prognostic information. Data from synoptic reporting tool can be imported to a relational database where they are organized and efficiently searched and retrieved. Since search and retrieval are streamlined, synoptic databases enhance basic science, clinical, and translational cancer research. Conclusion: Synoptic reporting facilitates a standard based structured method for entering the diagnostic and prognostic information in accurate and consistent fashion for a particular pathology specimen, thus reducing transcription services, specimen turnaround time, and typographical and transcription errors. The structured data can be imported into the Laboratory Information Service (LIS) database, which facilitates swift data access and improved communication for cancer management. Finally, these synoptic templates act as a robust medium of high-quality data from the various biospecimens, which can be shared across multiple on-going research projects to enhance basic and translational research.

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Section: Discussionmentioning

confidence: 99%

Utility and applications of synoptic reporting in pathology

Amin¹,

Sirintrapun²,

Parwani

2010

OAB

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“…Ideally, future interventions in this area will employ a sustainable, national infrastructure and will maintain a primary focus on achieving universal compliance Finally, these data may motivate surgeons, pathologists, laboratories, and hospitals further to achieve standardization of the basic content of surgical pathology reports. 1,2,[31][32][33] Standardized reporting has the potential to improve the reliability of pathologic data and, in turn, both the quality of clinical care and the validity of clinical and epidemiologic research in prostate cancer and other malignancies. 1 Directly relevant to this effort, the CAP protocol for RP specimens is published in checklist form and provides a standardized, universally available medium for recording and reporting essential pathologic information.…”

Section: Discussionmentioning

confidence: 99%

The quality of surgical pathology care for men undergoing radical prostatectomy in the U.S.

Miller

Spencer

Shah

et al. 2007

Cancer

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Amorphous‐made poly(L‐lactide) [i.e., poly(L‐lactic acid) (PLLA)], poly(L‐lactide‐co‐D‐lactide)[P(LLA‐DLA)](77/23), and P(LLA‐DLA)(50/50) films and PLLA films with different crystallinity (Xc) values were prepared, and the effects of molecular weight, D‐lactide unit content (tacticity and optical purity), and crystallinity of poly(lactide) [i.e., poly(lactic acid) (PLA)] on the water vapor permeability was investigated. The changes in number‐average molecular weight (Mn) of PLLA films in the range of 9 × 104–5 × 105 g mol−1 and D‐lactide unit content of PLA films in the range of 0–50% have insignificant effects on their water vapor transmission rate (WVTR). In contrast, the WVTR of PLLA films decreased monotonically with increasing Xc from 0 to 20%, while leveled off for Xc exceeding 30%. This is probably due to the higher resistance of “restricted” amorphous regions to water vapor permeation compared with that of the “free” amorphous regions. The free and restricted amorphous regions are major amorphous components of PLLA films for Xc ranges of 0–20% and exceeding 30%, respectively, resulting in the aforementioned dependence of WVTR on Xc. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci, 2006

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“…The purpose of this project is to standardize data collection and reporting for clinical trials by providing terminology for questions and values on CRFs (Tobias et al, 2006). The NIDCR used CDEs for its PBRN studies to identify discrete, defined items for data collection, promote consistent data collection in the field, eliminate unneeded or redundant data collection, and facilitate data-sharing.…”

Section: Methodsmentioning

confidence: 99%