We investigate the long term behavior in terms of finite dimensional global and exponential attractors, as time goes to infinity, of solutions to a semilinear reaction-diffusion equation on non-smooth domains subject to nonlocal Robin boundary conditions, characterized by the presence of fractional diffusion on the boundary. Our results are of general character and apply to a large class of irregular domains, including domains whose boundary is Hölder continuous and domains which have fractal-like geometry. In addition to recovering most of the existing results on existence, regularity, uniqueness, stability, attractor existence, and dimension, for the well-known reactiondiffusion equation in smooth domains, the framework we develop also makes possible a number of new results for all diffusion models in other non-smooth settings.2010 Mathematics Subject Classification. 35J92, 35A15, 35B41,35K65.