The cannabinoid receptor 2 is involved in acute rejection of cardiac allografts

Kemter, Andrea M.; Scheu, Stefanie; Hüser, Norbert; Ruland, Christina; Schumak, Beatrix; Findeiss, Matthias; Cheng, Zhao; Aßfalg, Volker; Arolt, Volker; Zimmer, Andreas; Alferink, Judith

doi:10.1016/j.lfs.2015.02.012

Cited by 10 publications

(13 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, it has been shown that CB 2 receptor activation ameliorated cerebral ischaemia by inhibiting neutrophil recruitment [24]. CB 2 receptor knockout mice were more prone to acute rejection of during allogenic heart transplantation by hampering pro-inflammatory cytokine production [25]. In contrast, other studies demonstrated that exposure to 2-arachidonylglycerol, an endogenous endocannabinoid, and certain CB 2 receptor agonists, JWH015 and JWH133, induced migration of B lymphocytes [34], natural killer cells [35], eosinophils [36] and monocytes [37].…”

Section: Discussionmentioning

confidence: 99%

“…Neuroprotective effect of JWH133, a CB 2 agonist, was also demonstrated in mice with ischaemic cerebral damage [24]. A recent report suggested a beneficial role of the CB 2 receptor in allograft protection [25]. Given that obesity, insulin resistance and T2D are all considered consequences of impaired immune responses [17], the CB 2 receptor may be regarded as novel therapy targets to ameliorate inflammation via which normalisation of fatty acid and glucose metabolism may be achieved.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cannabinoid 2 Receptor Agonist Improves Systemic Sensitivity to Insulin in High-Fat Diet/Streptozotocin-Induced Diabetic Mice

Zhang

Gao

Niu

et al. 2016

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: The endocannabinoid signalling (ECS) system has been known to regulate glucose homeostasis. Previous studies have suggested that the cannabinoid 2 (CB₂) receptor may play a regulatory role on insulin secretion, immune modulation and insulin resistance. Given that diabetes and insulin resistance are attributable to elevated inflammatory tone, we investigated the role of CB₂ receptor on glucose tolerance and insulin sensitivity in high-fat diet (HFD)/streptozotocin (STZ)-induced mice. Methods: Diabetes was induced in male ICR mice by HFD/STZ and exposed to a CB₂ receptor agonist, SER601, for 2- or 4-weeks via subcutaneous implantation of osmotic minipumps. Glucose and insulin tolerance tests were performed at the end of treatment. Islets were isolated for assessment of β-cell function. Pancreases and skeletal muscles were also obtained for histological analyses. Results: Despite a lack of impact on glucose tolerance, substantial improvement on insulin sensitivity was observed in SER601-treated mice, which could partly be attributed to improved islet β-cell function, shown as increased glucose-induced insulin secretion and insulin content. No changes on islet macrophage infiltration or skeletal muscle fat deposition were detectable from SER601-treated mice. However, a major decrease in body weight was recorded at the end of 4-week SER601 exposure, accompanied by a lack of epididymal adipose mass in SER601-treated mice. Conclusion: Our data suggest a lipolytic role of SER601 in HFD/STZ-induced diabetic mice, which results in significant improvement of systemic insulin sensitivity. Thus, the CB₂ receptor may be considered a promising target for therapeutic development against insulin resistance and obesity-related diabetes.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cannabinoid 2 Receptor Agonist Improves Systemic Sensitivity to Insulin in High-Fat Diet/Streptozotocin-Induced Diabetic Mice

Zhang

Gao

Niu

et al. 2016

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…Some interesting candidates have also emerged from the class of lipid mediators. The role played by the endocannabinoid system (ECS) in inflammation is now established [28]#, and the ECS was previously implicated in solid organ rejection [235,236]#. In mice, CB1/2 activation with tetrahydrocannabinol (THC) was able to mitigate aGvHD [237], whereas transplants where CB2 was knocked-down induced higher aGvHD [238].…”

Section: Resultsmentioning

confidence: 99%

The Biological and Clinical Relevance of G Protein-Coupled Receptors to the Outcomes of Hematopoietic Stem Cell Transplantation: A Systematized Review

Golay

Mlakar

et al. 2019

IJMS

View full text Add to dashboard Cite

Hematopoietic stem cell transplantation (HSCT) remains the only curative treatment for several malignant and non-malignant diseases at the cost of serious treatment-related toxicities (TRTs). Recent research on extending the benefits of HSCT to more patients and indications has focused on limiting TRTs and improving immunological effects following proper mobilization and engraftment. Increasing numbers of studies report associations between HSCT outcomes and the expression or the manipulation of G protein-coupled receptors (GPCRs). This large family of cell surface receptors is involved in various human diseases. With ever-better knowledge of their crystal structures and signaling dynamics, GPCRs are already the targets for one third of the current therapeutic arsenal. The present paper assesses the current status of animal and human research on GPCRs in the context of selected HSCT outcomes via a systematized survey and analysis of the literature.

show abstract

“…Moreover, the role of the endocannabinoid receptor CB2 in these processes is not clear [24]. The CB2 effect in allograft rejection was shown by Kemter et al [25]. In the study, CB2-deficient and wild-type mice underwent cardiac transplantation.…”

Section: Discussionmentioning

confidence: 99%

The Activation of Cannabinoid Type-2 Receptor with JWH-133 Protects Uterine Ischemia/Reperfusion-Induced Damage

2020

View full text Add to dashboard Cite

Introduction: Uterus transplantation is a complex surgical procedure. Uterine ischemia/reperfusion (IR) damage occurring in this process may cause loss of function in the uterus. Cell damage must be prevented for a healthy uterine function and successful transplantation. Cannabinoids, with their increasing clinical use, are substances with strong anti-inflammatory and antioxidative effects and have a role in immune system regulation. However, their efficacy in uterine IR damage is still unknown. This study provides information on the potential applications cannabinoids agonist JWH-133 in uterine IR damage and, hence, in the transplant process. Methods: Rats were divided into 4 groups (n = 8), performed uterine IR, and treated 2 groups with JWH-133. After anesthesia, ischemia was applied for 1 h to the uterus while reperfusion was applied for 3 h. After the experiment, malondialdehyde (MDA) levels and phosphorylated nuclear factor-kappa B (p-NF-κB) expression were examined in the tissue samples. Also, cell damage was evaluated by histopathological imaging and TUNEL staining. Results: In the uterine IR group, NF-κB expression and MDA levels were detected at high levels. Histopathological examinations and TUNEL staining revealed extensive cell damage. On the other hand, in groups treated with JWH-133, dose-dependent NF-κB expression and MDA levels decreased (p < 0.05). Depending on the dose, the rate of surviving cells increased in TUNEL staining results. Conclusion: The results showed that JWH-133 was effective in reducing uterine IR damage. Cannabinoids may be a new alternative that may be used in the transplantation process in the future.

show abstract

The cannabinoid receptor 2 is involved in acute rejection of cardiac allografts

Cited by 10 publications

References 43 publications

Cannabinoid 2 Receptor Agonist Improves Systemic Sensitivity to Insulin in High-Fat Diet/Streptozotocin-Induced Diabetic Mice

Cannabinoid 2 Receptor Agonist Improves Systemic Sensitivity to Insulin in High-Fat Diet/Streptozotocin-Induced Diabetic Mice

The Biological and Clinical Relevance of G Protein-Coupled Receptors to the Outcomes of Hematopoietic Stem Cell Transplantation: A Systematized Review

The Activation of Cannabinoid Type-2 Receptor with JWH-133 Protects Uterine Ischemia/Reperfusion-Induced Damage

Contact Info

Product

Resources

About