The cancer-retina antigen recoverin as a potential biomarker for renal tumors

Abstract

The renal cell carcinoma is the ninth most common cancer with an increasing occurrence and mortality. Recoverin is the first retina-specific photoreceptor protein that was shown to undergo aberrant expression, due to its promoter demethylation, as a cancer-retina antigen in a number of malignant tumors. In this work, we demonstrated that recoverin is indeed expressed in 68.4 % of patients with different subtypes of renal cell carcinoma, and this expression has tendency to correlate with tumor size. Interestingly, 91.7 % of patients with the benign renal tumor, oncocytoma, express recoverin as well in their tumor. Epigenetic analysis of the recoverin gene promoter revealed a stable mosaic methylation pattern with the predominance of the methylated state, with the exception of -80 and 56 CpG dinucleotides (CpGs). While the recoverin expression does not correlate withoverall survival of the tumor patients, the methylation of the recoverin gene promoter at -80 position is associated with better overall survival of the patients. This work is the first report pointing towards the association of overall survival of renal cell carcinoma (RCC) patients with promoter methylation of a cancer-retina antigen. Taken together, these data allow to consider recoverin as a potential therapeutic target and/or marker for renal tumors.

Dendritic Cells in Anticancer Vaccination: Rationale for Ex Vivo Loading or In Vivo Targeting

“…Thus, the identification of the tumor transcriptome and proteome to identify more immunogenic TSAs is helpful. Several highly immunogenic TSAs have already been described [260][261][262][263]. However, modern methods such as high-throughput sequencing technologies and bioinformatics analysis of big data allow the identification of new tumor antigenic determinants, such as neoantigens [264,265].…”

Autoimmune retinopathy and optic neuropathy associated with enolase-positive renal oncocytoma

“…6 , 7 , 8 Prior histologic studies have demonstrated that oncocytomas can produce known retinal antigens, including recoverin and neuron-specific (gamma) enolase. 9 , 10 This patient did not have anti-recoverin or anti-gamma enolase antibodies in his serum, and staining of the oncocytoma was negative for gamma enolase.…”

Dental status as a predictive factor in the development of squamous cell carcinoma of the oral mucosa

“…Исследования показывают [1][2][3], что многие заболевания полости рта значимо влияют на риски развития плоскоклеточного рака (ПЛР) слизистой оболочки полости рта (СОПР) [4][5][6]. Так, острые края зубов, протезов и пломб могут быть причиной хронической травмы СОПР [7,8], а наличие зубных отложений поддерживает хроническое воспаление пародонта [9,10], что в совокупности может инициировать развитие ПЛР.…”