The cancer preventive peptide lunasin from wheat inhibits core histone acetylation

Jeong, Hyung Jin; Jeong, Jin Boo; Kim, Dae Seop; Park, Jae Ho; Lee, Jung Bok; Kweon, Dae-Hyuk; Chung, Gyu Young; Seo, Eul Won; Lumen, Ben O. de

doi:10.1016/j.canlet.2007.03.022

Cited by 111 publications

(114 citation statements)

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“…Therefore, the decreased activity of histone acetyltransferases (HATs), including lysine acetyltransferase 2A/2B and p300, is consistent with the decreased incidence of cancer, including colorectal and breast cancer (47)(48)(49). In previous studies, lunasin was demonstrated to competitively inhibit HATs, thereby inhibiting acetylation and regulating the cell cycle (24,32). The underlying molecular mechanisms of the binding of lunasin to histones remain unclear; however, they may be associated with the helical structure formed by the amino acid residues at positions 23-31, and the specific spatial structure or orientation of lunasin (42).…”

Section: Molecular Mechanisms Of Lunasin In the Prevention And Treatmmentioning

confidence: 79%

“…Lunasin has been identified in soybean, barley, wheat and rye, and has been subjected to corresponding comparative analysis (24,25). However, due to the genotypic impact of different species, the lunasin content varies between species (26).…”

Section: Characterization Of Lunasinmentioning

confidence: 99%

“…Following oral administration of lunasin, it is absorbed into the bloodstream and reaches target tissues or organs in an active and stable state (31). Animal studies using rats fed on a soybean diet rich in lunasin demonstrated that the marked stability of lunasin enables it to reach target tissues and organs following administration, thus serving an important role in the prevention of cancer (24,32). The bioactivity of lunasin has been investigated in humans, and results have demonstrated that 4.5% lunasin at full activity is able to enter the plasma of healthy volunteers in 30 min (33).…”

Section: Molecular Mechanisms and Advantages Of Lunasin In The Prevementioning

confidence: 99%

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Lunasin: A promising polypeptide for the prevention and treatment of cancer

et al. 2017

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Abstract. Strategies for the treatment of cancer remain unsatisfactory due to the poor understanding of the complicated underlying molecular mechanisms of carcinogenesis. A number of types of cancer exhibit a marked association with dietary habits and lifestyles. Therefore, the modulation of dietary habits or lifestyles may be an effective strategy for preventing the formation and progression of cancer. Proteins and polypeptides from soybean have been developed as healthcare products due to their marked activity in inhibiting the progression of cancer at various stages. Lunasin, containing 43 amino acid residues, is one such example of a soybean-derived polypeptide that has been demonstrated to exhibit marked anti-cancer activity. In the present review, studies of the underlying molecular mechanisms and potential advantages of lunasin in the prevention and treatment of cancer have been examined, to provide a theoretical reference for the development of natural product-based agents or healthcare products for the prevention and treatment of cancer. IntroductionCancer is well-known to be one of the leading causes of mortality worldwide (1). However, the therapy of various types of cancer remains unsatisfactory due to the poor understanding of the complicated underlying molecular mechanisms of carcinogenesis. A number of epidemiological studies have demonstrated that a number of types of cancer exhibit a marked association with dietary habits and lifestyles (2-4). A statistical study has demonstrated that ~3.07 million individuals in China were diagnosed with cancer in 2012, which accounts for 1/5 of the total number of patients with cancer worldwide (5). Furthermore, ~2.21 million patients succumbed to cancer in China, which is ~25% of the total mortality worldwide due to cancer (5). Epidemiological evidence has demonstrated that cancer in 35% of patients exhibits a marked association with lifestyle, particularly diet (2). Therefore, the adjustment of dietary habits and lifestyles may be an effective strategy to prevent carcinogenesis. Cancer cell-and tumor-bearing animal models have demonstrated that the consumption of foods containing natural compounds with anti-cancer activity is able to markedly reduce the risk of cancer, and increase the sensitivity of cancer cells to treatment (6). A number of phytochemicals, including resveratrol, quercetin and flavonoids, have been demonstrated to exhibit marked anti-cancer activity (7-9). Similarly, foodborne proteins and polypeptides have attracted attention due to their specific advantages as anti-cancer substances (10,11). Compared with certain small-molecule drugs, polypeptides exhibit characteristics of increased affinity, marked ability of specific targeting and decreased toxicity; furthermore, polypeptides exhibit increased permeability in tissues compared with protein-based drugs (12). Therefore, polypeptides have been recognized as potential natural anti-cancer substances for inhibiting the development and progression of cancer at different stages (13).Following ...

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Section: Molecular Mechanisms Of Lunasin In the Prevention And Treatmmentioning

confidence: 79%

Section: Characterization Of Lunasinmentioning

confidence: 99%

Section: Molecular Mechanisms and Advantages Of Lunasin In The Prevementioning

confidence: 99%

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Lunasin: A promising polypeptide for the prevention and treatment of cancer

et al. 2017

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“…The purification of lunasin from plant sources is tedious. To date, lunasin has been isolated from various plants such as soybean (Odani et al, 1987b), barley (Jeong et al, 2002), herbs (Solanum nigrum L.; Jeong et al, 2007a), wheat (Jeong et al, 2007b), and amaranth (Amaranthus hypochondriacus; Silva-Sanchez et al, 2008). Natural lunasin has been extracted and purified by ion exchange chromatography and immuno-affinity column chromatography.…”

Section: Purification and Productionmentioning

confidence: 99%

“…The lunasin content of extracts from different varieties of barley ranges from 5.93 to 8.71 mg of lunasin per gram of protein (Jeong et al, 2002) and 36.4 mg of lunasin per gram of protein in Solanum nigrum L extract (Jeong et al, 2007a). Wheat and amaranth extracts have 3.95-17.2 mg lunasin per gram of protein (Jeong et al, 2007b) and 11.1 μg lunasin per gram of protein (Silva-Sanchez et al, 2008), respectively. Some heterologous eukaryotic proteins such as human insulin-like growth factor II, alphainterferon, and interleukin-2 have been expressed in E. coli (Dijkema et al, 1984).…”

Section: Purification and Productionmentioning

confidence: 99%