The Canadian systemic sclerosis oral health study: orofacial manifestations and oral health-related quality of life in systemic sclerosis compared with the general population

Baron, Murray; Hudson, Marie; Tatibouet, Solène; Steele, Russell; Lo, Ernest; Gravel, Simon-Pierre; Gyger, Geneviève; Sayegh, Tarek El; Pope, Janet; Fontaine, A.; Masseto, Ariel; Matthews, David; Sutton, Evelyn; Thie, Norman M.R.; Jones, Niall; Copete, Maria; Kolbinson, Dean A.; Markland, Janet; Nogueira-Filho, Getulio; Robinson, David; Gornitsky, Mervyn

doi:10.1093/rheumatology/ket441

Cited by 80 publications

(182 citation statements)

References 42 publications

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“…In our sample, the Modified Rodnan Skin Score was correlated with the worsening of maximum mouth opening and TMJ dysfunction in SSc patients. In addition to our results, emerging evidence indicates that the involvement of the orofacial region during SSc is usually associated with an impaired quality of life, emphasizing the need for a specific treatment related to this kind of disability (6). For these reasons a specific disease-related questionnaire quantifying mouth disability in SSc was developed (7).…”

Section: To the Editorsupporting

confidence: 64%

Incorrect Spelling of Author Name in the Article by George et al (Arthritis Care Res [Hoboken], January 2017)

2017

Arthritis Care & Research

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Section: To the Editorsupporting

confidence: 64%

Incorrect Spelling of Author Name in the Article by George et al (Arthritis Care Res [Hoboken], January 2017)

2017

Arthritis Care & Research

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“…Models were adjusted for age, gender, ethnicity (Caucasian vs. other), education (greater vs. less than high school) and current smoking. 8 In addition, the number of teeth was assessed as an offset term variable in the models for the number of teeth with widening. The study site was added as a random effect in all mixed models.…”

Section: Discussionmentioning

confidence: 99%

“…This study is the radiographic component of a large multi-site cross-sectional study looking at the orofacial manifestations and oral health-related quality of life in patients with SSc previously reported by Baron et al [8][9][10] In this study, 163 patients with SSc were recruited from 7 of the 15 Canadian Scleroderma Research Group sites. All patients had a diagnosis of SSc made by the participating rheumatologists.…”

Section: Methodsmentioning

confidence: 99%

“…7 We compared patients with SSc with a control population and demonstrated that oral problems in patients with SSc include decreased oral opening, decreased saliva production, increased number of missing teeth, and worse periodontal disease. [8][9][10] The radiographic manifestations in the jaws, considered characteristic of SSc, are welldefined bony erosions at the sites of muscle attachment in the mandible and increasing width of periodontal ligaments around teeth. 11 Only a few studies, however, have estimated the prevalence of these radiographic abnormalities, and none has included more than 47 patients with SSc.…”

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confidence: 99%

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The Canadian Systemic Sclerosis Oral Health Study IV: oral radiographic manifestations in systemic sclerosis compared with the general population

Dagenais

MacDonald

Baron

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Objective-The aim of this study was to compare oral radiologic abnormalities associated with systemic sclerosis (SSc) against abnormalities in the general population.Study Design-Patients with SSc and healthy controls were enrolled in a multi-site crosssectional study. Included in the radiology examination were a panoramic radiograph, four bitewings, and an anterior mandibular periapical radiograph. Radiographs were evaluated by two oral and maxillofacial radiologists tested for interobserver and intraobserver reliability. Chisquared tests, Fisher exact tests, and Mann Whitney U tests were used to summarize the radiologic manifestations of patients and controls.Results-We assessed 163 SSc patients and 231 controls. Widening of the periodontal ligament space (PLS) (P < .001), with higher percentage of teeth with PLS widening (P < .001), was significantly more frequent in patients with SSc than in controls. The most significant differences between the two groups were found in the molars and premolars (P < .001). Moreover, 26% of the patients with SSc had a periapical PLS greater than 0.19 mm compared with 13% of the controls (P = .003). Patients with SSc had significantly more erosions compared with controls (14.5% vs. 3.6%; P < .001), mostly in the condyles (P = .022), coronoid processes (P = .005) and other locations (P = .012). CIHR Author Manuscript CIHR Author Manuscript CIHR Author ManuscriptConclusion-Patients with SSc had more teeth with PLS widening and erosions of the mandible compared with controls.Systemic sclerosis (SSc) is a multi-system disorder of connective tissue characterized clinically by thickening and fibrosis of the skin and involvement of internal organs. Prevalence estimates for SSc are between 240 per million 1 and 276 per million 2 in an American population. The incidence rate of SSc is about 20 new cases per million per year. 3 It affects mainly women in their third or fourth decade of life and is associated with significant morbidity and increased mortality. No treatment has been shown to alter the natural history of SSc. 4 SSc is characterized by fibroblast dysfunction, which leads to fibrosis of the skin, internal organs, or both; 5 autoantibodies (anticentromere, antitopoisomerase I, anti-RNA polymerase III); and vasculopathy. 5,6 SSc is usually categorized into limited cutaneous SSc (lcSSc), diffuse cutaneous SSc (dcSSc), and SSc without skin involvement. 6 Although several candidate genes and regions of the genome have been identified as potentially being involved in SSc, these are also associated with other autoimmune conditions. SSc is a complex disease, where no single polymorphism is known to cause the complete manifestation of the condition; it has been suggested that it may be the combined action of several single nucleotide polymorphisms in different genes that may result in the complex traits of the disease. 7 We compared patients with SSc with a control population and demonstrated that oral problems in patients with SSc include decreased oral opening, decreased s...

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“…In researches conducted by rheumatologists and dentists, were cited a few manifestations of Speech, Language and Hearing Sciences studies, including microstomia, xerostomia, loss of gengival mucosa 5 , laryngeal impairment, oropharyngeal dysphagia 6,7 , difficulty in chewing, tongue rigidity, changes in the production of bilabial sounds due to the limitation of mandibular movements and vocal changes [8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Intervenção fonoaudiológica na esclerose sistêmica: relato de casos

et al. 2016

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Systemic sclerosis is a rare autoimmune rheumatic connective tissue disease, progressive of unknown etiology and variable evolution. Reaches vital organs and perioral tissues, causing limitation of mouth opening, stiffness of the articulators, face mask with appearance, difficulty in chewing and swallowing. Aiming to compare the pre and post intervention miofuncional speech orofacial in subjects with systemic sclerosis was performed qualiquantitativo exploratory clinical study in Rheumatology department of the University Hospital and Clinic, School of Speech Pathology, Federal University of Sergipe, from July / 2012 to December / 2013. The sample consisted of five individuals, of both genders, aged between 24 and 60 years and confirmed medical diagnosis of that condition. The subjects underwent evaluation by MBGR protocol and speech therapy (myofunctional and myoterapica), totaling 36 sessions. At the end, the initial and final results were compared from clinical indicators worked. After analyzing the results, improvements in all aspects worked were observed. The previous assessment of speech therapy revealed restriction of mouth opening in all subjects and the final results showed gains between 5.3 and 14.2mm opening (average: 9.26). Regarding tone, mobility of the articulators and orofacial numbness observed improvements and evidence of adequacy of oral functions. Can be concluded that although some patients still show changes in speech rehabilitation promoted significant improvements in clinical and quality of life of these individuals. Keywords: Speech, Language and Hearing Sciences; Scleroderma, Systemic; Speech Therapy RESUMO A Esclerose Sistêmica é uma doença reumática autoimune do tecido conjuntivo, progressiva, pouco frequente, de etiologia desconhecida e com evolução variável. Atinge órgãos nobres e tecidos periorais, causando limitação na abertura da boca, hipertonia dos órgãos fonoarticulatórios, face com "aparência de máscara", dificuldades na mastigação e deglutição. Com o objetivo de comparar os resultados pré e pós-intervenção fonoaudiológica miofuncional orofacial em sujeitos com esclerose sistêmica, realizou--se estudo clínico exploratório qualiquantitativo no setor de Reumatologia do Hospital Universitário e na Clínica escola de Fonoaudiologia da Universidade Federal de Sergipe, no período de julho/2012 a dezembro/2013. A amostra foi composta por cinco indivíduos, de ambos os gêneros, com faixa etária entre 24 e 60 anos e diagnóstico médico confirmado da referida afecção. Os indivíduos passaram por avaliação por meio do protocolo MBGR e 36 sessões de terapia fonoaudiológica (miofuncional e mioterápica). Ao término, os resultados iniciais e finais foram comparados a partir dos indicadores clínicos trabalhados. Diante da análise dos resultados obtidos, foram observadas melhoras em todos os aspectos trabalhados. A avaliação anterior à fonoterapia revelou restrição na abertura da boca em todos os indivíduos e os resultados finais apresentaram ganhos entre 5.3 e 14.2 mm de abertura (média: ...

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The Canadian systemic sclerosis oral health study: orofacial manifestations and oral health-related quality of life in systemic sclerosis compared with the general population

Abstract: Subjects with SSc have impaired oral health and oral HRQoL compared with the general population. These data can be used to develop targeted interventions to improve oral health and HRQoL in SSc.

Cited by 80 publications

References 42 publications

Incorrect Spelling of Author Name in the Article by George et al (Arthritis Care Res [Hoboken], January 2017)

Incorrect Spelling of Author Name in the Article by George et al (Arthritis Care Res [Hoboken], January 2017)

The Canadian Systemic Sclerosis Oral Health Study IV: oral radiographic manifestations in systemic sclerosis compared with the general population

Intervenção fonoaudiológica na esclerose sistêmica: relato de casos

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