The Canadian Dementia Imaging Protocol: Harmonization validity for morphometry measurements

Potvin, Olivier; Chouinard, Isabelle; Dieumegarde, Louis; Bartha, Robert; Bellec, Pierre; Collins, D. Louis; Descoteaux, Maxime; Hoge, Rick; Ramirez, Joel; Scott, Christopher J.; Smith, Eric E.; Strother, Stephen C.; Black, Sandra E.; Duchesne, Simon

doi:10.1016/j.nicl.2019.101943

Cited by 11 publications

(8 citation statements)

References 11 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The difference in parameters observed here is due to vendor specifications: In GE and Philips scanners, the TR represents an inner loop gradient echo TR, whereas in Siemens scanners the TR represents a magnetization‐prepared rapid gradient‐echo (MPRAGE) outer loop TR. (cf Potvin et al, , p. 4.…”

Section: Methodsmentioning

confidence: 99%

Reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants

Hassel

Sharma

Alders

et al. 2019

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

Task‐based functional neuroimaging methods are increasingly being used to identify biomarkers of treatment response in psychiatric disorders. To facilitate meaningful interpretation of neural correlates of tasks and their potential changes with treatment over time, understanding the reliability of the blood‐oxygen‐level dependent (BOLD) signal of such tasks is essential. We assessed test–retest reliability of an emotional conflict task in healthy participants collected as part of the Canadian Biomarker Integration Network in Depression. Data for 36 participants, scanned at three time points (weeks 0, 2, and 8) were analyzed, and intra‐class correlation coefficients (ICC) were used to quantify reliability. We observed moderate reliability (median ICC values between 0.5 and 0.6), within occipital, parietal, and temporal regions, specifically for conditions of lower cognitive complexity, that is, face, congruent or incongruent trials. For these conditions, activation was also observed within frontal and sub‐cortical regions, however, their reliability was poor (median ICC < 0.2). Clinically relevant prognostic markers based on task‐based fMRI require high predictive accuracy at an individual level. For this to be achieved, reliability of BOLD responses needs to be high. We have shown that reliability of the BOLD response to an emotional conflict task in healthy individuals is moderate. Implications of these findings to further inform studies of treatment effects and biomarker discovery are discussed.

show abstract

Section: Methodsmentioning

confidence: 99%

Reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants

Hassel

Sharma

Alders

et al. 2019

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

show abstract

“…Quantitative analyses, for example of WMH volume, have not been completed yet but the data will be made available later to the research community at large. Sequences for measuring brain volume 13 resting state functional MRI, 31 and diffusion tensor imaging have also been collected and can be used in later analyses. However, given time and resource constraints some advanced sequences relevant for vascular disease, for example for vascular reactivity and blood brain barrier permeability, 32 could not be included in the protocol.…”

Section: Discussionmentioning

confidence: 99%

“…Brain MRI are acquired using the previously validated Canadian Dementia Imaging Protocol (www.cdip-pcid.ca). 12,13 The protocol is summarized in Table 2. Compliant with the Standards for Reporting Vascular Changes on Imaging (STRIVE), 14 it was harmonized on three major vendor platforms and includes a common procedure for qualification, quality control, and quality assurance.…”

Section: Measurements and Outcomesmentioning

confidence: 99%

Vascular Contributions to Neurodegeneration: Protocol of the COMPASS-ND Study

Smith

Duchesne

Gao

et al. 2021

Can. J. Neurol. Sci.

Self Cite

View full text Add to dashboard Cite

Objective: To describe the neuroimaging and other methods for assessing vascular contributions to neurodegeneration in the Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) study, a Canadian multi-center, prospective longitudinal cohort study, including reliability and feasibility in the first 200 participants. Methods: COMPASS-ND includes persons with Alzheimer’s disease (AD; n = 150), Parkinson’s disease (PD) and Lewy body dementias (LBDs) (200), mixed dementia (200), mild cognitive impairment (MCI; 400), subcortical ischemic vascular MCI (V-MCI; 200), subjective cognitive impairment (SCI; 300), and cognitively intact elderly controls (660). Magnetic resonance imaging (MRI) was acquired according to the validated Canadian Dementia Imaging Protocol and visually reviewed by either of two experienced readers blinded to clinical characteristics. Other relevant assessments include history of vascular disease and risk factors, blood pressure, height and weight, cholesterol, glucose, and hemoglobin A1c. Results: Analyzable data were obtained in 197/200 of whom 18 of whom were clinically diagnosed with V-MCI or mixed dementia. The overall prevalence of infarcts was 24.9%, microbleeds was 24.6%, and high white matter hyperintensity (WMH) was 31.0%. MRI evidence of a potential vascular contribution to neurodegeneration was seen in 12.9%–40.0% of participants clinically diagnosed with another condition such as AD. Inter-rater reliability was good to excellent. Conclusion: COMPASS-ND will be a useful platform to study vascular brain injury and its association with risk factors, biomarkers, and cognitive and functional decline across multiple age-related neurodegenerative diseases. Initial findings show that MRI-defined vascular brain injury is common in all cognitive syndromes and is under-recognized clinically.

show abstract

“…ONDRI as well as other projects have contributed to the development of and adopted the harmonized Canadian Dementia Imaging Protocol [32,33] (http://www.cdip-pcid.ca), which aims to harmonize the acquisition of magnetic resonance images. At minimum, we recommend a 3D T1-weighted scan (1 mm), FLAIR at 1.5T, and gradient echo.…”

Section: Discussionmentioning

confidence: 99%

Structural Brain Magnetic Resonance Imaging to Rule Out Comorbid Pathology in the Assessment of Alzheimer’s Disease Dementia: Findings from the Ontario Neurodegenerative Disease Research Initiative (ONDRI) Study and Clinical Trials Over the Past 10 Years

Kapoor

Bartha

Black

et al. 2020

JAD

Self Cite

View full text Add to dashboard Cite

Background/Objective: Structural brain magnetic resonance imaging (MRI) is not mandatory in Alzheimer's disease (AD) research or clinical guidelines. We aimed to explore the use of structural brain MRI in AD/mild cognitive impairment (MCI) trials over the past 10 years and determine the frequency with which inclusion of standardized structural MRI acquisitions detects comorbid vascular and non-vascular pathologies. Methods: We systematically searched ClinicalTrials.gov for AD clinical trials to determine their neuroimaging criteria and then used data from an AD/MCI cohort who underwent standardized MRI protocols, to determine type and incidence of clinically relevant comorbid pathologies. Results: Of 210 AD clinical trials, 105 (50%) included structural brain imaging in their eligibility criteria. Only 58 (27.6%) required MRI. 16,479 of 53,755 (30.7%) AD participants were in trials requiring MRI. In the observational AD/MCI cohort, 141 patients met clinical criteria; 22 (15.6%) had relevant MRI findings, of which 15 (10.6%) were exclusionary for the study. Discussion: In AD clinical trials over the last 10 years, over two-thirds of participants could have been enrolled without brain MRI and half without even a brain CT. In a study sample, relevant comorbid pathology was found in 15% of participants, despite careful screening. Standardized structural MRI should be incorporated into NIA-AA diagnostic guidelines (when available) and research frameworks routinely to reduce diagnostic heterogeneity.

show abstract

The Canadian Dementia Imaging Protocol: Harmonization validity for morphometry measurements

Cited by 11 publications

References 11 publications

Reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants

Reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants

Vascular Contributions to Neurodegeneration: Protocol of the COMPASS-ND Study

Structural Brain Magnetic Resonance Imaging to Rule Out Comorbid Pathology in the Assessment of Alzheimer’s Disease Dementia: Findings from the Ontario Neurodegenerative Disease Research Initiative (ONDRI) Study and Clinical Trials Over the Past 10 Years

Contact Info

Product

Resources

About