The cAMP pathway regulates mRNA decay through phosphorylation of the RNA-binding protein TIS11b/BRF1

Rataj, Felicitas; Planel, Séverine; Desroches-Castan, Agnès; Douce, Juliette Le; Lamribet, Khadija; Denis, Jean‐Noël; Feige, Jean‐Jacques; Cherradi, Nadia

doi:10.1091/mbc.e16-06-0379

Cited by 23 publications

(33 citation statements)

References 48 publications

(38 reference statements)

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“…Interestingly, no classical CRE was identified within the −2,000 bp upstream of the TSS of the two other family members TTP and TIS11d. In agreement with this observation, TTP or TIS11d mRNA levels were not changed upon ACTH challenge, pointing at a specific induction of TIS11b by the hormone in the adrenal cortex (23). …”

Section: Acth Action On Mrna Decay Mechanisms: From Transcription To supporting

confidence: 81%

“…TIS11b S334D phospho-mimick mutants presented a reduced association with CNOT1, a core subunit of the CCR4–NOT deadenylase complex, but however displayed an enhanced interaction with the decapping enzyme Dcp1a. Unexpectedly, this interaction was associated with an increased mRNA-destabilizing activity of TIS11b S334D as compared to the dephospho-form of TIS11b (23). These observations suggest that combinatorial phosphorylations of TIS11b on specific residues do not systematically abrogate their mRNA-destabilizing capability but rather fine-tune their interactions with the mRNA decay machineries.…”

Section: Acth Action On Mrna Decay Mechanisms: From Transcription To mentioning

confidence: 92%

“…HuR and alternatively spliced isoforms of AUF1/hnRNPD are also expressed in adrenal cells (6, 22). Recently, it was established that ACTH induced zfp36-L1 gene transcription in bovine adrenocortical cells (BAC) through phosphorylation of CREB transcription factor and CREB-mediated activation of TIS11b promoter (23). A highly conserved cAMP response element (CRE) was found at -402 to -394 relative to the transcription start site (TSS) of human zfp36-L1 gene.…”

Section: Acth Action On Mrna Decay Mechanisms: From Transcription To mentioning

confidence: 99%

“…A new ACTH-regulated phosphorylation site recently identified in TIS11b seems, however, to mediate a different biological response. ACTH-mediated activation of PKA was reported to induce the phosphorylation of TIS11b on two serine residues, S54 and S334 (23) (Figure 1B). Analysis of phospho-dead (S54A, S334A) and phospho-mimick (S54D, S334D) TIS11b mutants revealed that S54 regulates the binding of TIS11b to 14.3.3 protein but that S334 does not play a significant role in this interaction.…”

Section: Acth Action On Mrna Decay Mechanisms: From Transcription To mentioning

confidence: 99%

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ACTH Action on Messenger RNA Stability Mechanisms

2017

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The regulation of mRNA stability has emerged as a critical control step in dynamic gene expression. This process occurs in response to modifications of the cellular environment, including hormonal variations, and regulates the expression of subsets of proteins whose levels need to be rapidly adjusted. Modulation of messenger RNA stability is usually mediated by stabilizing or destabilizing RNA-binding proteins (RNA-BP) that bind to the 3′-untranslated region regulatory motifs, such as AU-rich elements (AREs). Destabilizing ARE-binding proteins enhance the decay of their target transcripts by recruiting the mRNA decay machineries. Failure of such mechanisms, in particular misexpression of RNA-BP, has been linked to several human diseases. In the adrenal cortex, the expression and activity of mRNA stability regulatory proteins are still understudied. However, ACTH- or cAMP-elicited changes in the expression/phosphorylation status of the major mRNA-destabilizing protein TIS11b/BRF1 or in the subcellular localization of the stabilizing protein Human antigen R have been reported. They suggest that this level of regulation of gene expression is also important in endocrinology.

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Section: Acth Action On Mrna Decay Mechanisms: From Transcription To supporting

confidence: 81%

Section: Acth Action On Mrna Decay Mechanisms: From Transcription To mentioning

confidence: 92%

Section: Acth Action On Mrna Decay Mechanisms: From Transcription To mentioning

confidence: 99%

Section: Acth Action On Mrna Decay Mechanisms: From Transcription To mentioning

confidence: 99%

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ACTH Action on Messenger RNA Stability Mechanisms

2017

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“…Previous studies have shown that cAMP/PKA can regulate mRNA stability by directly altering the activity of proteins involved in mRNA decay. For instance, cAMP-elicited phosphorylation of TIS11b, which targets some mRNAs for degradation, plays a key regulatory role in its mRNA decay-promoting function (66).…”

Section: The Journal Of Clinical Investigation R E S E a R C H A R T mentioning

confidence: 99%

Neogenin neutralization prevents photoreceptor loss in inherited retinal degeneration

Charish¹,

Shabanzadeh²,

Chen³

et al. 2020

Journal of Clinical Investigation

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Diverse functions of deadenylases in DNA damage response and genomic integrity

Yan

2020

WIREs RNA

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DNA damage response (DDR) is a coordinated network of diverse cellular processes including the detection, signaling, and repair of DNA lesions, the adjustment of metabolic network and cell fate determination. To deal with the unavoidable DNA damage caused by either endogenous or exogenous stresses, the cells need to reshape the gene expression profile to allow efficient transcription and translation of DDR‐responsive messenger RNAs (mRNAs) and to repress the nonessential mRNAs. A predominant method to adjust RNA fate is achieved by modulating the 3′‐end oligo(A) or poly(A) length via the opposing actions of polyadenylation and deadenylation. Poly(A)‐specific ribonuclease (PARN) and the carbon catabolite repressor 4 (CCR4)‐Not complex, the major executors of deadenylation, are indispensable to DDR and genomic integrity in eukaryotic cells. PARN modulates cell cycle progression by regulating the stabilities of mRNAs and microRNA (miRNAs) involved in the p53 pathway and contributes to genomic stability by affecting the biogenesis of noncoding RNAs including miRNAs and telomeric RNA. The CCR4‐Not complex is involved in diverse pathways of DDR including transcriptional regulation, signaling pathways, mRNA stabilities, translation regulation, and protein degradation. The RNA targets of deadenylases are tuned by the DDR signaling pathways, while in turn the deadenylases can regulate the levels of DNA damage‐responsive proteins. The mutual feedback between deadenylases and the DDR signaling pathways allows the cells to precisely control DDR by dynamically adjusting the levels of sensors and effectors of the DDR signaling pathways. Here, the diverse functions of deadenylases in DDR are summarized and the underlying mechanisms are proposed according to recent findings. This article is categorized under: RNA Processing > 3' End Processing RNA in Disease and Development > RNA in Disease RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms

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The cAMP pathway regulates mRNA decay through phosphorylation of the RNA-binding protein TIS11b/BRF1

Cited by 23 publications

References 48 publications

ACTH Action on Messenger RNA Stability Mechanisms

ACTH Action on Messenger RNA Stability Mechanisms

Neogenin neutralization prevents photoreceptor loss in inherited retinal degeneration

Diverse functions of deadenylases in DNA damage response and genomic integrity

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