The calculation of formation curves of metal complexes from pH titration curves in mixed solvents

Irving, H. M. N. H.; Rossotti, Hazel

doi:10.1039/jr9540002904

Cited by 674 publications

(217 citation statements)

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“…Results were plotted in the form of a graph which indicate ligand metal ratio as 2:1(L 2 M). This ratio was also confirmed by Job's method 14 of continuous variation as modified by Turner and Anderson 15 The graphs were plotted which indicates 2:1 ligand metal ratio, Fig.2(a, b); from these curves the stability constant (Log k) and free energy (-ΔF) of the complex was also calculated [16][17] and reported in table 1…”

Section: Ligand-metal Ratiomentioning

confidence: 99%

Synthesis, Spectral characterization and X-ray Diffraction Studies of Cerium Complex of Glipizide, an Oral Antidiabetic Drug

Prakash¹,

Krishan²,

Jacob³

2013

Orientjchem.

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Glipizide is one of the most commonly prescribed drugs for the treatment of type 2 Diabetes mellitus 1 . It is about 100 times more potent than tolbutamide in evoking pancreatic secretion of insulin 2 . It is absorbed rapidly, uniformly with good mean oral bioavailability. It offers several advantages such as swift and short action with a very high selectivity 3-4 . It is a white or almost white crystalline, odourless powder, practically tasteless, insoluble in water and alcohols, but soluble in 0.1 N NaOH; it is freely soluble in dimethylformamide. ABSTRACTGlipizide is a second generation sulphonylurea with promising hypoglycemic activity. It acts by stimulating the release of insulin from β-cells of pancreas. The present paper describes the synthesis and characterization of cerium complex with Glipizide. The conductometric titration using monovariation method reveal that complex is non-ionic and ML 2 type which was further confirmed by Job's method of continuous variation as modified by Turner and Anderson. The analytical data agree with the molecular formula (C 21 H 26 N 5 O 4 S) 2 Ce(OH 2 ) 2 , that the structure of complex was assigned as octahedral in which ligand molecules lies horizontally joining the central cerium atom. IR, NMR confirms the co-ordination of sulphonyl oxygen on one side and enolic oxygen attached from other side with the metal ion. The structure of complex was proposed on the basis of analytical data, elemental analysis, IR, 1 H NMR and X-ray Diffraction studies.

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Section: Ligand-metal Ratiomentioning

confidence: 99%

Synthesis, Spectral characterization and X-ray Diffraction Studies of Cerium Complex of Glipizide, an Oral Antidiabetic Drug

Prakash¹,

Krishan²,

Jacob³

2013

Orientjchem.

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“…Figure 5. Plot of pH of acid (X) and acid + compound (■) against volume of NaOH (V) for PAB-1 at 303.15 K From these titration curves, the average number of protons associated with the compound ( H n ) can be calculated by using Irving and Rossotti equation [23]. …”

Section: Dissociation Constant Studymentioning

confidence: 99%

Determination of Dissociation Constants of Some Novel Tetrahydropyrimidine Derivatives in Mixed Organic-Water System by Simple pH Measurement

Baluja¹,

Bhesaniya²,

Patel³

2017

MOCR

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Abstract. Some tetrahydropyrimidine derivatives have been synthesized and their structures have been confirmed by IR, 1 H NMR, 13 C NMR and mass spectral data. The dissociation constants of these derivatives of tetrahydropyrimidine have been measured by Calvin Bjerrum pH titration method in DMF-water (60: 40 v/v) system at 303.15 K. It is observed that dissociation constant depends on substituent groups present in the compounds.

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“…The manifold research work has been done on the study of metal and nitrogen heterocyclic ligands containing complexes (Irving H, 1954;Martell, 1962). Many workers have reported their results on metal-ligand stability constants.…”

Section: Introductionmentioning

confidence: 99%

pH Metric Studies of Interaction of Synthesized Ligands 2-amino-4-hydroxy-6-methylpyrimidine and 1-(4-hydroxy-6-methylpyrimidino)-3-phenylthiocarbamide with Cu(II), Cd(II), Cr(II), Cations At 0.1 M Ionic Strength

Tayade¹,

Pund²,

Bhagwatkar³

et al. 2011

IJC

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Guanidine was successfully interacted with acetoacetic ester to synthesize 2-amino-4-hydroxy-6-methylpyrimidine (L 1 ) which on further treatment with phenylisothiocyanate furnishes 1-(4-hydroxy-6-methylpyrimidino)-3-phenylthiocarbamide (L 2 ). The interactions of Cu(II), Cd(II), Cr(II) metal ions with L 1 and L 2 have been studied at 0.1 M ionic strength in 70 % Dioxane-water mixture by Bjerrum method as adopted by Calvin and Wilson, It is observed that Cu(II), Cd(II), Cr(II) metal ions form 1:1 and 1:2 complexes with ligands (L 1 and L 2 ). The data obtained were used to estimate and compare the values of proton-ligand stability constant (pK.) and metal-ligand stability constants (log k).The effect of substituents were studied from estimated data (pK & log k).

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The calculation of formation curves of metal complexes from pH titration curves in mixed solvents

Cited by 674 publications

References 0 publications

Synthesis, Spectral characterization and X-ray Diffraction Studies of Cerium Complex of Glipizide, an Oral Antidiabetic Drug

Synthesis, Spectral characterization and X-ray Diffraction Studies of Cerium Complex of Glipizide, an Oral Antidiabetic Drug

Determination of Dissociation Constants of Some Novel Tetrahydropyrimidine Derivatives in Mixed Organic-Water System by Simple pH Measurement

pH Metric Studies of Interaction of Synthesized Ligands 2-amino-4-hydroxy-6-methylpyrimidine and 1-(4-hydroxy-6-methylpyrimidino)-3-phenylthiocarbamide with Cu(II), Cd(II), Cr(II), Cations At 0.1 M Ionic Strength

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