The Calcium Channel Affect Osteogenic Differentiation of Mesenchymal Stem Cells on Strontium-Substituted Calcium Silicate/Poly-ε-Caprolactone Scaffold

Tp, Su; Huang, Tsui‐Hsien; Kao, Chia‐Tze; Ng, Hooi Yee; Chiu, Yung-Cheng; Hsu, Tuan-Ti

doi:10.3390/pr8020198

Cited by 13 publications

(6 citation statements)

References 47 publications

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“…The FGSr and FGSrB scaffolds have irregular contour structures and many inorganic aggregates distributed evenly on the surface of the scaffold. According to literature, BMP-2 was known to enhance bone regeneration and it was hypothesized that BMP-2 works by increasing hydroxyapatite formation, thus enhancing bone formation and integration with living tissues [32]. After 3 days of immersion, SEM images showed that there were apatite aggregations on the surfaces of both scaffolds.…”

Section: Scaffold Fabricationmentioning

confidence: 99%

Effect of Bone Morphogenic Protein-2-Loaded Mesoporous Strontium Substitution Calcium Silicate/Recycled Fish Gelatin 3D Cell-Laden Scaffold for Bone Tissue Engineering

Wang

Liu

et al. 2020

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Bone has a complex hierarchical structure with the capability of self-regeneration. In the case of critical-sized defects, the regeneration capabilities of normal bones are severely impaired, thus causing non-union healing of bones. Therefore, bone tissue engineering has since emerged to solve problems relating to critical-sized bone defects. Amongst the many biomaterials available on the market, calcium silicate-based (CS) cements have garnered huge interest due to their versatility and good bioactivity. In the recent decade, scientists have attempted to modify or functionalize CS cement in order to enhance the bioactivity of CS. Reports have been made that the addition of mesoporous nanoparticles onto scaffolds could enhance the bone regenerative capabilities of scaffolds. For this study, the main objective was to reuse gelatin from fish wastes and use it to combine with bone morphogenetic protein (BMP)-2 and Sr-doped CS scaffolds to create a novel BMP-2-loaded, hydrogel-based mesoporous SrCS scaffold (FGSrB) and to evaluate for its composition and mechanical strength. From this study, it was shown that such a novel scaffold could be fabricated without affecting the structural properties of FGSr. In addition, it was proven that FGSrB could be used for drug delivery to allow stable localized drug release. Such modifications were found to enhance cellular proliferation, thus leading to enhanced secretion of alkaline phosphatase and calcium. The above results showed that such a modification could be used as a potential alternative for future bone tissue engineering research.

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Section: Scaffold Fabricationmentioning

confidence: 99%

Effect of Bone Morphogenic Protein-2-Loaded Mesoporous Strontium Substitution Calcium Silicate/Recycled Fish Gelatin 3D Cell-Laden Scaffold for Bone Tissue Engineering

Wang

Liu

et al. 2020

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“…Relevant effects on MSCs are exerted by Sr, including (i) stimulation of cell proliferation, (ii) enhancement of Ca deposition as mineral nodules by von Kossa stain, (iii) increased osteogenic differentiation by alkaline phosphatase (ALP) staining [ 51 ], and by upregulation of the expression of extracellular matrix (ECM)-related genes: type I collagen (COL1), bone sialoprotein (BSP) and osteocalcin (OCN) [ 52 ].…”

Section: Effect Of Strontium On Mesenchymal Stem Cellsmentioning

confidence: 99%

Strontium Functionalization of Biomaterials for Bone Tissue Engineering Purposes: A Biological Point of View

et al. 2022

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Strontium (Sr) is a trace element taken with nutrition and found in bone in close connection to native hydroxyapatite. Sr is involved in a dual mechanism of coupling the stimulation of bone formation with the inhibition of bone resorption, as reported in the literature. Interest in studying Sr has increased in the last decades due to the development of strontium ranelate (SrRan), an orally active agent acting as an anti-osteoporosis drug. However, the use of SrRan was subjected to some limitations starting from 2014 due to its negative side effects on the cardiac safety of patients. In this scenario, an interesting perspective for the administration of Sr is the introduction of Sr ions in biomaterials for bone tissue engineering (BTE) applications. This strategy has attracted attention thanks to its positive effects on bone formation, alongside the reduction of osteoclast activity, proven by in vitro and in vivo studies. The purpose of this review is to go through the classes of biomaterials most commonly used in BTE and functionalized with Sr, i.e., calcium phosphate ceramics, bioactive glasses, metal-based materials, and polymers. The works discussed in this review were selected as representative for each type of the above-mentioned categories, and the biological evaluation in vitro and/or in vivo was the main criterion for selection. The encouraging results collected from the in vitro and in vivo biological evaluations are outlined to highlight the potential applications of materials’ functionalization with Sr as an osteopromoting dopant in BTE.

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“…of the contrast in vertical permeability is quantified by the Dykstra-Parson coefficient [55], denoted by V DP , and defined by:…”

Section: Drainage Areamentioning

confidence: 99%

Optimization and uncertainty quantification model for time-continuous geothermal energy extraction undergoing re-injection

Hoteit¹,

He²,

Yan³

et al. 2021

Preprint

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Geothermal field modeling is often associated with uncertainties related to the subsurface static properties and the dynamics of fluid flow and heat transfer. Uncertainty quantification using simulations is a useful tool to design optimum field-development alternatives and to guide decision-making. The optimization process includes assessments of multiple time-dependent flow mechanisms, which are functions of operational parameters subject to subsurface uncertainties. This process requires careful determination of the parameter ranges, dependencies, and their probabilistic distribution functions. This study presents a new approach to assess time-dependent predictions of thermal recovery and produced-enthalpy rates, including uncertainty quantification and optimization. We use time-continuous and multi-objective uncertainty quantification for geothermal recovery, undergoing a water re-injection scheme. The ranges of operational and uncertainty parameters are determined from a collected database, including 135 geothermal fields worldwide. The uncertainty calculation is conducted non-intrusively, based on a workflow that couples low-fidelity models

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The Calcium Channel Affect Osteogenic Differentiation of Mesenchymal Stem Cells on Strontium-Substituted Calcium Silicate/Poly-ε-Caprolactone Scaffold

Cited by 13 publications

References 47 publications

Effect of Bone Morphogenic Protein-2-Loaded Mesoporous Strontium Substitution Calcium Silicate/Recycled Fish Gelatin 3D Cell-Laden Scaffold for Bone Tissue Engineering

Effect of Bone Morphogenic Protein-2-Loaded Mesoporous Strontium Substitution Calcium Silicate/Recycled Fish Gelatin 3D Cell-Laden Scaffold for Bone Tissue Engineering

Strontium Functionalization of Biomaterials for Bone Tissue Engineering Purposes: A Biological Point of View

Optimization and uncertainty quantification model for time-continuous geothermal energy extraction undergoing re-injection

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