The calcifying odontogenic cyst—a possible analogue of the cutaneous calcifying epithelioma of Malherbe

Calcifying Cystic Odontogenic Tumor

“…Although the lesion has been commonly recognized as a benign odontogenic cyst since Gorlin et al first described it in 1962 [1], this pathologic entity encompasses a spectrum of clinical behavior and histopathological features including cystic, solid (neoplastic) and aggressive (malignant) variants [2][3][4][5][6][7]. As a result of this diversity, different classification schemes and nomenclature for the lesion and its variants have been suggested.…”

Extraosseous calcifying odontogenic cyst: a case report and a literature review

“…The COC is also known as Gorlin cyst since its initial description, in 1962, by that author (8) . It is considered a unique entity with both cystic and neoplastic behavior.…”

“…The calcifying odontogenic cyst (COC) is a rare odontogenic lesion first described as a distinct entity by Gorlin et al, in 1962 (8) . Since then, literature shows a large controversy regarding terminology and classification in spite of the currently acceptation of Gorlin's original designation by the World Health Organization (WHO) in 1971 (17) .…”

Controversies in Odontogenic Tumours: Review

“…35 Future case reports may shed more light on this new lesion. Calcifying odontogenic cysts (COCs) were first identified as a specific type of odontogenic lesion by Gorlin et al 36 However, controversy has since arisen regarding the association between non-neoplastic cystic lesions and solid tumour masses with similar cellular and histomorphological features. The 1971 WHO classification described COC tumours as a non-neoplastic cystic lesion, while the description was updated to state that "most lesions appear to be non-neoplastic" in the 1992 edition.…”