The calcification <i>in vitro</i> of kidney, lung and aorta

Rosenheim, Adèle Helen; Robison, Robert

doi:10.1042/bj0280712

Cited by 22 publications

(3 citation statements)

References 6 publications

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“…Supraphysiological concentrations of phosphate are necessary to induce calcification in vessels in vitro 28,30–32 and the extent of calcification varies directly with the phosphate concentration. 28 Similarly, vascular calcification in uremic rats or mice requires a high phosphorus diet with substantial hyperphosphatemia.…”

Section: Therapies Related To Disordered Bone and Mineral Metabolismmentioning

confidence: 99%

Recent progress in the treatment of vascular calcification

O’Neill

Lomashvili

2010

Kidney International

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Vascular calcification is common in patients with advanced chronic kidney disease and is associated with poorer outcomes. Although the pathophysiology is not completely understood, it is clear that it is a multifactorial process involving altered mineral metabolism, as well as changes in systemic and local factors that can promote or inhibit vascular calcification, and all of these are potential therapeutic targets. Current therapy is closely linked to strategies for preventing disordered bone and mineral metabolism in advanced kidney disease and involves lowering the circulating levels of both phosphate and calcium. The efficacy of compounds that specifically target calcification, such as bisphosphonates and thiosulfate, has been shown in animals but only in small numbers of humans, and safety remains an issue. Additional therapies, such as pyrophosphate, vitamin K, and lowering of pH, are supported by animal studies, but are yet to be investigated clinically. As the mineral composition of vascular calcifications is the same as in bone, potential effects on bone must be addressed with any therapy for vascular calcification.

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Section: Therapies Related To Disordered Bone and Mineral Metabolismmentioning

confidence: 99%

Recent progress in the treatment of vascular calcification

O’Neill

Lomashvili

2010

Kidney International

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“…of investigations on the isolation, the mode-of-action and the distribution of phosphoric esterases in different tissues [4][5][6][7][8][9][10][11][12][13] .…”

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confidence: 99%

Biochemistry meets biology: Key findings for bone calcification and a lifetime philosophy of collaboration

Murphy

Poole

2011

The Biochemist

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“…It should not be forgotten, however, that an essentially similar technique had been devised and developed by R. Robison and his associates (14,15,16,17) in England between 1923 and 1934 for the demonstration of phosphatase which must play an important role in the mechanism of calcification of bone. They finally used thin sections of tissues and an incubation mixture with and without substrate.…”

mentioning

confidence: 99%

Macromolecular glycogen synthesis induced from enzyme histochemistry.

Takeuchi

1981

Acta Histochem. Cytochem

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The calcification in vitro of kidney, lung and aorta

Cited by 22 publications

References 6 publications

Recent progress in the treatment of vascular calcification

Recent progress in the treatment of vascular calcification

Biochemistry meets biology: Key findings for bone calcification and a lifetime philosophy of collaboration

Macromolecular glycogen synthesis induced from enzyme histochemistry.

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