The caffeic acid moiety plays an essential role in attenuating lipid accumulation by chlorogenic acid and its analogues

Cao, Xiaoxue; Wu, Chongming; Tian, Yu; Guo, Peng

doi:10.1039/c8ra09395d

Cited by 9 publications

(8 citation statements)

References 38 publications

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“…is result indicated that caffeic acid can effectively attenuate hepatic lipid accumulation, which was in accordance with the previous research: it was proved that the TG clearance was over 50% in oil acid induced HepG2 cells with the treatment of 40 μg/mL of caffeic acid [22]. Moreover, a previous study found that caffeic acid moiety in chlorogenic acid and its analogues were supposed to play a key role in the lipid-lowering activities of those compounds [23]. erefore, the suppression effects of OPF phenolic fractions on hepatic fat accumulation probably attributed to caffeic acid and/or compounds with a similar structure.…”

Section: Phenolic Fractions and Caffeic Acid Attenuated The Pa-supporting

confidence: 90%

Different Phenolic Extracts of Oil Palm Fruits and Caffeic Acid Prevent Palmitic Acid-Induced Lipotoxicity in HepG2 Cells via Improving Mitochondrial Function

Liu

Wang

Zhou

et al. 2020

Journal of Food Quality

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Oil palm (Elaeis guineensis Jacq.) fruits are rich in antioxidative phenolic compounds, which exert various health improving effects. This study aimed to comparatively study the protective effects of different phenolic fractions from the fruits treated with or without ultrahigh pressure (UHP) and their most abundant phenolic substance, caffeic acid, against the palmitic acid-induced lipotoxicity in HepG2 cells and to clarify the potential mechanisms. Results showed that the TG accumulation, intracellular reactive oxygen species content, cell apoptosis, and mitochondrial membrane potential depolarization were relieved by the administration of those phenolic fractions and caffeic acid. The protection of insoluble-bound (IB) phenolic fraction was the best, and UHP treatment significantly enhanced its protective effect on lipotoxicity. The lipotoxicity preventive effect may be achieved by alleviating intracellular oxidative stress, downregulating the expression of P-P38, COX-2, and iNOS to relieve inflammation, and downregulating Bax and cytochrome C and upregulating Bcl-2 to suppress the mitochondrial-mediated apoptosis. Therefore, the oil palm fruits phenolic fractions, especially the IB phenolic fraction, might be utilized as dietary antioxidants to relieve the adverse effects of a high-fat diet on the body, and UHP treatment is a potential method to increase this bioactivity.

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Section: Phenolic Fractions and Caffeic Acid Attenuated The Pa-supporting

confidence: 90%

Different Phenolic Extracts of Oil Palm Fruits and Caffeic Acid Prevent Palmitic Acid-Induced Lipotoxicity in HepG2 Cells via Improving Mitochondrial Function

Liu

Wang

Zhou

et al. 2020

Journal of Food Quality

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“…4. CA derivates can downregulate lipogenic genes (SREBP1c/1a, acetyl-CoA carboxylase, and fatty acid synthase) and upregulate lipolytic genes [56].…”

Section: Discussionmentioning

confidence: 99%

Cinnamic acid ameliorate gentamicin-induced liver dysfunctions and nephrotoxicity in rats through induction of antioxidant activities

Babaeenezhad

Nouryazdan

Nasri

et al. 2021

Heliyon

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This study was the first to evaluate the possible protective effects of cinnamic acid (CA) against Gentamicin (GM) induced liver and kidney dysfunctions in rats. Adult male Wistar rats were randomly assigned to 4 equal groups (n ¼ 8): Control group (saline, 0.5 ml/day), CA group (CA, 50 mg/kg/day), GM group (GM, 100 mg/kg/day), and GM þ CA group (100 & 50 mg/kg/day). Following 12 days of treatments, blood and 24 h urine samples were collected and kidneys were taken out for biochemical, histopathological, and molecular studies. Following CA treatment, renal function markers and transaminases activities including serum urea (59.92%) and creatinine (50.41%), protein excretion rate (43.67%), and serum activities of aspartate aminotransferase (AST) (54.34%) and alanine aminotransferase (ALT) (47.26%) significantly reduced in the treated group as compared with the GM group (P < 0.05). Also, CA could significantly ameliorate the levels of triglyceride (29.70%), cholesterol (13.02%), very low-density lipoprotein (29.69%) and high-density lipoprotein-cholesterol (7.28%). CA could also attenuate oxidative stress through a decrease of serum malondialdehyde (MDA) (50.86%) and nitric oxide (NO) (0.85%) and an increase of renal catalase (CAT) (196.14%) and glutathione peroxidase (GPX) activities (45.88%) as well as GPX mRNA expression (44.42-fold) as compared with the GM group (P < 0.05). Moreover, histopathological evaluations revealed attenuated tubular damages and reduced inflammatory cellular infiltration in CA treated animals. Overall, CA alleviates GM-induced nephrotoxicity and alterations in transaminases activities in rats through its antioxidant activities.

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“…[16,[43][44][45] Moreover, the two new characteristic peaks in the range of 1,274-1,261 and 820-817 cm −1 correspond to the stretching vibrations of υ(B-O) and υ(B-C) groups of chiral dioxaborinane derivatives (T (1-2) B (1-2) ) and (T (1-2) B (1-2) -N), respectively. [26,46] Furthermore, two peaks observed in the range of 1,382-1,365 and 486-480 cm −1 , which could be attributed to ferrocene υ(C-C) and υ (Fe-C) stretchings in the framework of chiral dioxaborinane complexes, respectively.Electronic transitions of ligands (T 1 and T 2 ) and their chiral dioxaborinane (T (1-2) B (1-2) ) and (T (1-2) B (1-2) -N) complexes were studied in C 2 H 5 OH and CHCl 3 (2.10 −6 -2.10 −8 M) at room temperature and recorded at λ max as nm. The UV-Vis spectral data of all chiral compounds are given in Figure S17-22 and the experimental section.…”

Section: Spectroscopic Studiesmentioning

confidence: 97%

Synthesis of cis‐1,2‐diol‐type chiral ligands and their dioxaborinane derivatives: Application for the asymmetric transfer hydrogenation of various ketones and biological evaluation

Kılıç

Balci

Arslan

et al. 2020

Applied Organom Chemis

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Two cis‐1,2‐diol‐type chiral ligands (T1 and T2) and their tri‐coordinated chiral dioxaborinane (T(1–2)B(1–2)) and four‐coordinated chiral dioxaborinane adducts with 4‐tert‐butyl pyridine sustained by N → B dative bonds (T(1–2)B(1–2)‐N) were synthesized and characterized by various spectroscopic techniques such as NMR (1H, 13C, and 11B), FT‐IR and UV–Vis spectroscopy, LC–MS/MS, and elemental analysis. It was suggested that both ferrocene and trifluoromethyl groups played key roles in the catalytic and biological studies because they could tune the solubility of the chiral dioxaborinane complexes and adjust the strength of intermolecular interactions. To assess the biological activities of newly synthesized chiral dioxaborinane compounds, DPPH (2,2‐diphenyl‐1‐picrylhydrazyl) radical scavenging, reducing power, antibacterial, DNA binding, and DNA cleavage activities were tested. Then, all chiral dioxaborinane complexes were investigated as catalysts for the asymmetric transfer hydrogenation of various ketones under suitable conditions. The results indicated that the chiral dioxaborinane catalysts performed well with high yields.

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The caffeic acid moiety plays an essential role in attenuating lipid accumulation by chlorogenic acid and its analogues

Abstract: The phenolic hydroxyl on the caffeic acid moiety is essential for the lipid-lowering activity of chlorogenic acid.

Cited by 9 publications

References 38 publications

Different Phenolic Extracts of Oil Palm Fruits and Caffeic Acid Prevent Palmitic Acid-Induced Lipotoxicity in HepG2 Cells via Improving Mitochondrial Function

Different Phenolic Extracts of Oil Palm Fruits and Caffeic Acid Prevent Palmitic Acid-Induced Lipotoxicity in HepG2 Cells via Improving Mitochondrial Function

Cinnamic acid ameliorate gentamicin-induced liver dysfunctions and nephrotoxicity in rats through induction of antioxidant activities

Synthesis of cis‐1,2‐diol‐type chiral ligands and their dioxaborinane derivatives: Application for the asymmetric transfer hydrogenation of various ketones and biological evaluation

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