The caecocolonic junction in humans has a sphincteric anatomy and function.

Pellegrini, Maria Simonetta Faussone; Manneschi, Lidia Ibba

doi:10.1136/gut.37.4.493

Cited by 20 publications

(12 citation statements)

References 7 publications

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“…2) suggests the presence of the ryanodine receptor (see for instance Figure 4 in [42]). We assume that TC-CM interaction is essential not only for cardiac development [15,20], renewal [2,3,11] and repair [2] but also plays a significant role in cardiac physiology. In conclusion, this study proves that TCs and CMs are unequivocally physical connected and might represent a 'functional unit' of the heart.…”

Section: Fig 4 Et Shows Nanocontacts (Arrows) Connecting the Cellulamentioning

confidence: 99%

“…TCs are interstitial cells with exceptionally long cellular processes -telopodes (Tp) -which form an interstitial network connecting different types of cell from myocardium [4][5][6][7][8], epicardium [9,10,13], endocardium [14] and cardiac stem cell niches [3,11]. The concept of TCs was adopted by other laboratories [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

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Heterocellular communication in the heart: electron tomography of telocyte-myocyte junctions

Gherghiceanu

Popescu

2011

Journal of Cellular and Molecular Medicine

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Myocardium is composed of two main cell populations: cardiomyocytes (CMs) and interstitial cells (e.g. fibroblasts, immunoreactive cells, capillaries). However, very recently we have showed that a novel type of interstitial cell called telocytes (TCs) does exist in epi-, myo- and endocardium. They have very long and thin telopodes (Tp) formed by alternating podomeres and podoms. Heterocellular communication between TCs and CMs it is supposed to occur by shed vesicles and close apposition. If TCs have to play a role in cardiac physiology it is expected to develop direct and unambiguous contacts with CMs. Because a clear membrane-to-membrane junction has not been reported by electron microscopy we have investigated the heterocellular communication in the mouse heart by electron tomography. This advanced technique showed that small dense structures (10–15 nm nanocontacts) directly connect TCs with CMs. More complex and atypical junctions could be observed between TCs and CMs at the level of intercalated discs. This study proves that TCs and CMs are directly connected and might represent a ‘functional unit’.

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Section: Fig 4 Et Shows Nanocontacts (Arrows) Connecting the Cellulamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Heterocellular communication in the heart: electron tomography of telocyte-myocyte junctions

Gherghiceanu

Popescu

2011

Journal of Cellular and Molecular Medicine

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“…In health, the ascending and transverse regions of the colon function as reservoirs and the descending colon acts as a conduit 6 . While this reservoir function has been characterized functionally, there is also evidence for an anatomical ‘sphincter’ characterized by a circumferential narrowing by a fold located at the caeco‐ascending colon junction 7 . The colon is extremely efficient at conserving sodium and water, a facility which is particularly important in sodium‐depleted patients in whom the small intestine alone is unable to maintain sodium balance.…”

Section: Introductionmentioning

confidence: 99%

Review article: colonic sensorimotor physiology in health, and its alteration in constipation and diarrhoeal disorders

Camilleri

Ford

1998

Aliment Pharmacol Ther

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Aim: To review the physiology of colonic motility and sensation in healthy humans and the pathophysiological changes associated with constipation and diarrhoea. Source: Medline Search from 1965 using the index terms: human, colonic motility, sensation, pharmacology, neurohormonal control, gastrointestinal transit, constipation, diarrhoea and combinations of these. Results: In health, the ascending and transverse regions of colon function as reservoirs to accommodate ileal chyme and the descending colon acts as a conduit; the neuromuscular functions and transmitters control colonic motility and sensation and play pivotal roles in disorders associated with constipation and/or diarrhoea. Disorders of proximal colonic transit contribute to symptoms in idiopathic constipation, diarrhoea‐predominant irritable bowel syndrome and carcinoid diarrhoea. Colonic function in patients presenting with constipation is best assessed clinically by colonic transit time using radiopaque markers ingested orally. Measurements of colonic contractility are less useful clinically but they can help identify motor abnormalities including colonic inertia; in some patients with irritable bowel syndrome, abdominal pain, urgency and diarrhoea are temporally associated with high amplitude contractions, which originate in the proximal colon and traverse the distal conduit at very high propagation velocities. Visceral hypersensitivity contributes to the urgency and tenesmus in irritable bowel syndrome and inflammatory bowel disease. Colonic motility and sensation can be reduced by anticholinergic agents, somatostatin analogues and 5HT3 antagonists. Conclusion: Physiological and pharmacological studies of the human colon have provided new insights into the pathophysiology of colonic disorders, and offer possibilities of novel therapeutic approaches for constipation or diarrhoea associated with colonic motor or sensory dysfunction.

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“…reported a median number of three bowel movements per day and night after right colonic transposition. The ileocaecal junction functions as a sphincter and the colon slows down transit time considerably . Thus, colonic rotation to perform a tension‐free colorectal anastomosis could be an alternative to a total colectomy with an ileorectal anastomosis.…”

Section: Discussionmentioning

confidence: 99%