The Ca2+/Calmodulin-dependent
Calcineurin/NFAT Signaling Pathway in the Pathogenesis of Insulin
Resistance in Skeletal Muscle
Magdalena Danowska,
Marek Strączkowski
Abstract:Skeletal muscle is the tissue directly involved in insulin-stimulated glucose
uptake. Glucose is the primary energy substrate for contracting muscles, and
proper metabolism of glucose is essential for health. Contractile activity and
the associated Ca2+signaling regulate functional capacity and
muscle mass. A high concentration of Ca2+and the presence of
calmodulin (CaM) leads to the activation of calcineurin (C… Show more
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