The Ca/P range of nanoapatitic calcium phosphate cements

Driessens, F. C. M.; Boltong, M. G.; Maeyer, Erna A. P. De; Wenz, R.; Nies, Berthold; Planell, Josep A.

doi:10.1016/s0142-9612(02)00151-5

Cited by 75 publications

(31 citation statements)

References 35 publications

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“…However, this formula is still a simplified version since it does not account for the alkali and carbonate ions incorporated into the structure. 37 Driessens et al 38 have studied the synthesis of resorbable, Na-and K-containing CDHA self-setting cements. Under highly alkaline conditions (i.e., pH Ͼ10) of synthesis and precipitate aging, the formed apatitic calcium phosphates would have lesser amounts of vacancies in their OH sites.…”

Section: Resultsmentioning

confidence: 99%

Chemical Processing of CaHPO₄·2H₂O:

Taş

Bhaduri

2004

Journal of the American Ceramic Society

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The aim of this paper is to develop a robust chemical process to synthesize Na-and K-doped brushite (DCPD: dicalcium phosphate dihydrate, CaHPO 4 ⅐2H 2 O), a potential starting material for bone substitutes. The powders were synthesized by using sodium phosphate and potassium phosphate and aqueous solutions containing calcium chloride at room temperature, followed by drying at 37°C. DCPD powders thus formed were found to contain 460 ppm K and 945 ppm Na. On calcination in air, these powders readily transformed into monetite (DCPA: dicalcium phosphate anhydrous, CaHPO 4 ) first, and then into Ca 2 P 2 O 7 (calcium pyrophosphate). Na-and K-doped DCPD powders were shown to completely transform, in less than 1 week, into poorly crystalline carbonated apatite on immersion in an acellular simulated/synthetic body fluid (SBF) solution at 37°C. The Tris (i.e., tris(hydroxymethyl)aminomethane) buffered SBF solution used in this study had a carbonate ion concentration of 27 mM equal to that of human plasma. DCPD powders of this study displayed a notable apatite-inducing ability. This finding suggests the use of these DCPD powders as the starting materials for potential bone substitutes, which can be easily manufactured in aqueous solutions friendly to living tissues, at temperatures between room temperature and 37°C.

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Section: Resultsmentioning

confidence: 99%

Chemical Processing of CaHPO₄·2H₂O:

Taş

Bhaduri

2004

Journal of the American Ceramic Society

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“…), strontium orthophosphate [72][73][74], magnesium orthophosphate [74][75][76][77][78], magnesium oxide [79], Zn-containing compounds [80], as well as cements made of various ion substituted calcium orthophosphates (e.g., Ca 2 KNa(PO 4 ) 2 , NaCaPO 4 , Na 3 Ca 6 (PO 4 ) 5 , magnesium substituted CDHA, strontium substituted CDHA, etc.) [81][82][83][84][85][86][87][88][89][90] are available. Furthermore, self-setting formulations might be prepared in the reaction-setting mixture of Ca(OH) 2 -KH 2 PO 4 system [91], as well as by treatment of calcium carbonates with orthophosphate solutions [92].…”

Section: Introductionmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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“…The final product of both cements is a calcium-deficient hydroxyapatite. However, the reaction product of cement R has a higher solubility than that of cement H, and is more similar to the mineral phase of bone [19][20][21]. Moreover, the two cements have shown different cell responses in vitro.…”

Section: Introductionmentioning

confidence: 99%