The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-17

Abstract

Field of the paper: Immunology Original paperThe C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-17

The effect of psychoactive bacteria, Bifidobacterium longum Rosell®-175 and Lactobacillus rhamnosus JB-1, on brain proteome profiles in mice

“…In mice, GlyR α4-mediated glycinergic neurotransmission may modulate social, startle, and anxiety-like behaviour Darwish et al ( 2023 ) Secreted frizzled-related protein 3 SFRP3 A modulator of the Wnt signalling pathway that among others regulates diverse developmental processes in the embryonic brain and adult hippocampal neurogenesis Jang et al ( 2013a , b ) Carbonic anhydrase 2 CAII An enzyme that reversibly converts carbon dioxide and water to bicarbonate and H + , it is involved in the regulation of pH homeostasis in the brain Boone et al ( 2013 ), Lemon et al ( 2021 ) Nucleoplasmin-2 NPM2 A protein involved in chromatin condensation, it plays important role during initial stages of embryonic development but the function of this protein in the brain remains unknown Burns et al ( 2003 ), Lingenfelter et al ( 2011 ) Eukaryotic translation initiation factor 4H EIF4H A factor involved in protein synthesis at the level of initiation phase, necessary for the proper development and brain morphology Capossela et al ( 2012 ) Shadow of prion protein SPRN A PrP-like protein, its role is not fully known. It may be involved in the control of cellular proliferation and differentiation of various tissues Passet et al ( 2020 ) C-type lectin domain family 1 member A CLEC1A A member of CLR receptors family involved in the defence against pathogens, it can be involved in the development of CNS inflammation by up-regulating transport of Th17 cells through the blood–brain barrier Makusheva et al ( 2022 ) Interleukin-18 IL-18 A pro-inflammatory cytokine, an important mediator of inflammation and host immune response. It also modulates neuronal functions, mediates communication between the CNS and PNS, and regulates the activity of the hypothalamic–pituitary axis Alboni et al ( …”

“…Clec1A is one of the CLR receptors taking part in the host’s defence against pathogens and is also involved in regulating immune system function and the development of autoimmune and neoplastic processes (Makusheva et al 2022 ). This protein also plays an important role in the development of CNS inflammation by upregulating transport of Th17 cells through the blood–brain barrier (Arima et al 2012 ; Makusheva et al 2022 ).…”

“…Clec1A is one of the CLR receptors taking part in the host’s defence against pathogens and is also involved in regulating immune system function and the development of autoimmune and neoplastic processes (Makusheva et al 2022 ). This protein also plays an important role in the development of CNS inflammation by upregulating transport of Th17 cells through the blood–brain barrier (Arima et al 2012 ; Makusheva et al 2022 ). The low expression of this protein in the experimental groups receiving psychobiotics may indicate that there were no ongoing inflammatory processes in the CNS, autoimmune processes, or tissue degradation.…”