Abstract:Protein degradation is one of the essential mechanisms that enables
reshaping of the proteome landscape in response to various stimuli. The
largest E3 ubiquitin ligase family that targets proteins to degradation by
catalyzing ubiquitination is the cullin–RING ligases (CRLs). Many of the
proteins that are regulated by CRLs are central to tumorigenesis and tumor
progression, and dysregulation o… Show more
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