2015
DOI: 10.1016/j.abb.2014.10.015
|View full text |Cite
|
Sign up to set email alerts
|

The C-terminal region of the human p23 chaperone modulates its structure and function

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
19
2
2

Year Published

2015
2015
2024
2024

Publication Types

Select...
5
1

Relationship

2
4

Authors

Journals

citations
Cited by 21 publications
(25 citation statements)
references
References 46 publications
2
19
2
2
Order By: Relevance
“…They also have a positive CD signal at 230 nm, which is a structural sign reported for the hp23 protein . In addition, we used hydrodynamic tools to show that both Lbp23 proteins are elongated monomers in solution, similar to the observations for hp23 . SAXS experiments corroborate these conclusions and indicate that both Lbp23 proteins have sufficiently long dimensions to interact simultaneously with both the N‐ and M‐domains of LbHsp90 .…”
Section: Discussionsupporting
confidence: 76%
“…They also have a positive CD signal at 230 nm, which is a structural sign reported for the hp23 protein . In addition, we used hydrodynamic tools to show that both Lbp23 proteins are elongated monomers in solution, similar to the observations for hp23 . SAXS experiments corroborate these conclusions and indicate that both Lbp23 proteins have sufficiently long dimensions to interact simultaneously with both the N‐ and M‐domains of LbHsp90 .…”
Section: Discussionsupporting
confidence: 76%
“…However, HMS analysis highlighted the major species as being the Hsp90 dimer linked to 3 p23s and a maximum binding stoichiometry of 4 p23s per Hsp90 dimer. This result is in contradiction with previous works showing binding stoichiometries of 1 and 2 p23s per dimer[36,38,39,41,60]. Such stoichiometry is atypical but not aberrant.…”
contrasting
confidence: 84%
“…Purified p23 was analyzed by analytical ultracentrifugation and by SEC-MALLS. Velocity analytical ultracentrifugation experiments gave us the sedimentation coefficient at 20°C in water at infinite dilution (s 20,°w ) of 1.9 S (data not shown, Table 1) identical to that determined by [36]. p23 molecular masses of 20.5 kDa and 21.1 kDa were respectively determined by SEC-MALLS and HMS.…”
Section: P23 Is Correctly Foldedmentioning
confidence: 99%
See 2 more Smart Citations