The Bypass Angioplasty Revascularization in Type 1 and Type 2 Diabetes study: 5-year follow-up of revascularization with percutaneous coronary intervention versus coronary artery bypass grafting in diabetic patients with multivessel disease

Kapur, Akhil; Bartolini, Davide; Finlay, Malcolm; Qureshi, Ayesha C.; Flather, Marcus; Strange, Julian; Hall, Roger

doi:10.2459/jcm.0b013e328330ea32

Cited by 11 publications

(3 citation statements)

References 29 publications

(25 reference statements)

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“…This survey showed a higher prevalence of diabetic patients with previous PCI or coronary artery bypass graft (CABG) participating to CR programs. Patients with diabetes undergoing myocardial revascularization have worse survival than other CAD patients [23][24][25][26]. Several studies have reported that PCI in patients with diabetes may be associated with poor long-term results [27,28].…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and course of patients with diabetes entering cardiac rehabilitation

Giallauria

Fattirolli

Tramarin

et al. 2015

Diabetes Research and Clinical Practice

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics and course of patients with diabetes entering cardiac rehabilitation

Giallauria

Fattirolli

Tramarin

et al. 2015

Diabetes Research and Clinical Practice

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“…Unfortunately, according to the literature, within 10 years, vein graft failure occurs in nearly half of the conduits . Additionally, patients with diabetic mellitus (DM) tend to have accompanying more advanced, rapidly progressing vein graft disease compared with non‐diabetic patients . The leading cause of vein graft failure is intimal hyperplasia, which is defined as excessive smooth muscle cells (SMC) proliferation and migration in the intima of SV graft wall .…”

Section: Introductionmentioning

confidence: 99%

Advanced glycation end products impair the functions of saphenous vein but not thoracic artery smooth muscle cells through RAGE/MAPK signalling pathway in diabetes

Sun

Kang

Jun

et al. 2016

J Cellular Molecular Medi

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Saphenous vein (SV) and internal thoracic artery (ITA) are commonly used bypass conduits. However, graft failure occurs in SV rather than in ITA, especially in diabetes (DM). The mechanism for this difference has not been fully understood. Accumulation of advanced glycation end products (AGEs) and activation of AGEs receptor (RAGE) could accelerate smooth muscle cells (SMC) proliferation in DM, we thus asked whether AGEs‐RAGE could mediate the differences between SMC from SV (SMCV) and from ITA (SMCA). Twenty‐five patients with DM and other 25 patients without DM were enclosed in DM and control group, respectively. AGEs (100 μg/ml) were added to cultured SMCA and SMCV obtained at coronary artery bypass graft (CABG) and proliferative rates were determined. Transcript expression, phosphorylation or protein expression levels of MAP kinase family (ERK, p38 and JNK), matrix metalloproteinases (MMP)‐2 and MMP‐9 were analysed by real‐time PCR, Western‐blot or immunofluorescence staining, respectively. Compared with paired SMCA, SMCV showed significantly increased proliferation rate, MAP kinase family phosphorylation, and MMP‐2/9 expression in both groups, especially in DM group. The responses of SMCV induced by AGEs were significantly larger in DM than in control group, which could be suppressed by inhibition of RAGE and ERK. However, all the cellular events of SMCV were not found in paired SMCA. This study suggests that AGEs‐RAGE could induce the proliferation of SMCV but not SMCA via MAP kinase pathway in DM. It is the intrinsic ‘inactive’ tendency of SMCA that contributes to the different rates of graft disease between SV and ITA after CABG.

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“…Most other trials have been small, single-center, non-randomized trials or meta-analyses. Many of these studies show improved outcomes for CABG over PCI [50][51][52][53][54][55]; but others were less convincing [56].…”

Section: Revascularization In Patients With Dm and Mvd: Pci Versus Cabgmentioning

confidence: 99%

Revascularization strategies in patients with Type 2 diabetes mellitus

Choi

Mehran

2013

Expert Review of Cardiovascular Therapy

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This review aims to describe new developments in coronary revascularization strategies for patients with pre-existing Type 2 diabetes mellitus (DM). Recommended strategies for revascularization have been an active area of study with recent important developments. In patients with Type 2 DM and multivessel coronary artery disease (CAD), coronary artery bypass graft (CABG) surgery is the preferred method for revascularization. Patients with DM are at increased risk for diffuse cardiovascular disease due to the proinflammatory, prothrombotic effects of chronic hyperglycemia. In patients undergoing percutaneous coronary intervention, drug-eluting stents and more potent antiplatelet agents especially in those presenting with acute coronary syndromes should be employed.

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The Bypass Angioplasty Revascularization in Type 1 and Type 2 Diabetes study: 5-year follow-up of revascularization with percutaneous coronary intervention versus coronary artery bypass grafting in diabetic patients with multivessel disease

Cited by 11 publications

References 29 publications

Clinical characteristics and course of patients with diabetes entering cardiac rehabilitation

Clinical characteristics and course of patients with diabetes entering cardiac rehabilitation

Advanced glycation end products impair the functions of saphenous vein but not thoracic artery smooth muscle cells through RAGE/MAPK signalling pathway in diabetes

Revascularization strategies in patients with Type 2 diabetes mellitus

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