The burden of vitiligo: Patient characteristics associated with quality of life

Homan, May W. Linthorst; Spuls, Phyllis I.; Korte, J. de; Bos, Jan D.; Sprangers, Mirjam A. G.; Veen, J.P.W. van der

doi:10.1016/j.jaad.2009.03.022

Cited by 159 publications

(114 citation statements)

References 42 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has also been reported that the social life of vitiligo patients is impaired by the tendency of these patients to withdraw from friends and to avoid going out. 24,25 In this regard, the present study also determined that daily activities, leisure, work, and personal relationships were all significantly improved after treatment.…”

Section: Discussionsupporting

confidence: 60%

Treatment of Vitiligo Patients by Excimer Laser Improves Patients’ Quality of Life

Al‐Shobaili

2015

J Cutan Med Surg

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 60%

Treatment of Vitiligo Patients by Excimer Laser Improves Patients’ Quality of Life

Al‐Shobaili

2015

J Cutan Med Surg

View full text Add to dashboard Cite

show abstract

“…This was interesting to us as this finding contrasts with vitiligo, a disease characterized by dyspigmentation, which exhibits emotional and functional impairment, as measured by the Skindex-29 17,25 and where it has been shown that quality of life is more affected in dark-skinned patients.…”

Section: Discussionmentioning

confidence: 98%

“…Other diseases with damage effects similar to lupus, such as dyspigmentation, have demonstrated a negative effects on quality of life. 17 Therefore we anticipated that the damage experienced in cutaneous lupus patients, namely dyspigmentation and scarring, should also have a negative effect on quality of life, and that a difference should be seen between patients of different racial backgrounds.…”

Section: Introductionmentioning

confidence: 99%

The impact of skin damage due to cutaneous lupus on quality of life

et al. 2014

View full text Add to dashboard Cite

Summary Background It has already been shown that patients with more severe CLE activity have a poorer quality of life (QoL). Racial and ethnic disparities have been reported in disease activity and outcomes in SLE, but similar information is not available in CLE. Objective The main objective of the current study was to evaluate the impact of lupus-related skin damage on skin-specific QoL, as well as differences stratified by ethnic backgrounds. Methods Data collected included sex, race, diagnosis, CLASI scores, and Skindex-29. These parameters were analysed at the initial and last visits. CLASI damage scores (dyspigmentation and scarring) and CLASI activity scores were collected, grouped by ethnicity, and correlated with Skindex-29. 223 patients were analysed at baseline, with 141 of these patients completing more than one study visit. Results The majority were Caucasians (63.7%), followed by African Americans (29.1%) and Asian Americans (4.0%). African American patients accounted for a disproportionate percentage of both localised (50% of cases) and generalised (48.9% of cases) DLE. Median CLASI damage scores significantly differed between our African American, Caucasian, and Asian American patients, at both first (8.5, 4.0, 7.0) (Kruskal-Wallis p<0.0001) and last visit (10.0, 6.0, 8.5) (Kruskal-Wallis p<0.01) (Dunn's Multiple Comparison p<0.0001, p<0.01). CLASI damage scores in African Americans correlated with CLASI activity scores (Spearman's r=0.45, p=0.0003). Conclusion There was no significant correlation between CLASI damage scores and Skindex domains overall. Individually, dyspigmentation and scarring also did not have a significant effect on QoL. In conclusion, disease damage does not affect QoL, as measured by the Skindex-29. Ethnic differences in CLE patients were found: African American patients with CLE, do exhibit a high rate of DLE, experience damage early in their disease course, frequently in conjunction with disease activity.

show abstract

“…Extent of involvement is highly variable, ranging from focal to generalized, and the onset can be abrupt or gradual. Although essentially asymptomatic, the psychosocial impact of vitiligo can be devastating, and affected persons are often desperate for effective therapy [1]. As of 2010, this goal has not yet been reached, as the underlying pathomechanisms in vitiligo are still incompletely understood, despite intense scrutiny.…”

Section: Introductionmentioning

confidence: 99%

Vitiligo, reactive oxygen species and T-cells

2010

View full text Add to dashboard Cite

The acquired depigmenting disorder of vitiligo affects an estimated 1% of the world population and constitutes one of the commonest dermatoses. Although essentially asymptomatic, the psychosocial impact of vitiligo can be severe. The cause of vitiligo remains enigmatic, hampering efforts at successful therapy. The underlying pathogenesis of the pigment loss has, however, been clarified to some extent in recent years, offering the prospect of effective treatment, accurate prognosis and rational preventative strategies. Vitiligo occurs when functioning melanocytes disappear from the epidermis. A single dominant pathway is unlikely to account for all cases of melanocyte loss in vitiligo; rather, it is the result of complex interactions of biochemical, environmental and immunological events, in a permissive genetic milieu. ROS (reactive oxygen species) and H2O2 in excess can damage biological processes, and this situation has been documented in active vitiligo skin. Tyrosinase activity is impaired by excess H2O2 through oxidation of methionine residues in this key melanogenic enzyme. Mechanisms for repairing this oxidant damage are also damaged by H2O2, compounding the effect. Numerous proteins and peptides, in addition to tyrosinase, are similarly affected. It is possible that oxidant stress is the principal cause of vitiligo. However, there is also ample evidence of immunological phenomena in vitiligo, particularly in established chronic and progressive disease. Both innate and adaptive arms of the immune system are involved, with a dominant role for T-cells. Sensitized CD8+ T-cells are targeted to melanocyte differentiation antigens and destroy melanocytes either as the primary event in vitiligo or as a secondary promotive consequence. There is speculation on the interplay, if any, between ROS and the immune system in the pathogenesis of vitiligo. The present review focuses on the scientific evidence linking alterations in ROS and/or T-cells to vitiligo.

show abstract

The burden of vitiligo: Patient characteristics associated with quality of life

Cited by 159 publications

References 42 publications

Treatment of Vitiligo Patients by Excimer Laser Improves Patients’ Quality of Life

Treatment of Vitiligo Patients by Excimer Laser Improves Patients’ Quality of Life

The impact of skin damage due to cutaneous lupus on quality of life

Vitiligo, reactive oxygen species and T-cells

Contact Info

Product

Resources

About