The Burden of Sinusitis in Hematologic Transplant Patients: A National Perspective

Pandrangi, Vivek; Reiter, Evan R.

doi:10.1002/lary.27363

Cited by 3 publications

(4 citation statements)

References 20 publications

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Section: Introductionmentioning

confidence: 99%

“…A recent retrospective review of a nationwide hospital database showed that in patients undergoing hematologic transplant, the presence of sinusitis is associated with higher total hospital charges and increased length of stay. 13 Given the lack of specific data for the management of CRS in liver and kidney transplant recipients, the aim of this study is to describe the presentation of CRS in this patient population, characterize its clinical course, and to determine patient and treatment factors that impact CRS outcomes in this population.…”

Section: Introductionmentioning

confidence: 99%

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Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant

Spillinger

Low

Smith

et al. 2021

World j. otorhinolaryngol.-head neck surg.

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Objective This study aims to describe presenting characteristics of patients diagnosed with non-invasive chronic rhinosinusitis (CRS) following liver or kidney transplant and determine factors associated with disease-related complications, selection of endoscopic sinus surgery (ESS), and disease resolution in this population. Study design Retrospective chart review. Setting An academic tertiary care center (Mayo Clinic, Rochester, Minnesota). Subjects and methods Liver and kidney transplant recipients evaluated by Mayo Clinic otolaryngologists for CRS between 1998 and 2018 were identified. Univariate and multivariate logistic regression analyses were used to determine patient factors and treatment modalities associated with developing complications, selection of ESS, and disease resolution. Results Fifty-seven patients met inclusion criteria. No patients developed intraorbital or intracranial complications of their CRS. Multivariate modeling demonstrated that the presence of polyps ( P = 0.036) was associated with undergoing ESS within one year of presentation. A higher Lund–Mackay (LM) computed tomography score ( P = 0.023) and older age ( P = 0.018) were significantly associated with decreased disease resolution. No other factors were significantly associated with the use of endoscopic sinus surgery within one year of otolaryngology presentation or resolution of CRS in this cohort. Conclusion The risk of developing CRS-related intraorbital or intracranial complications in this immunecompromised patient cohort may be lower than originally thought. For liver- and kidney-recipients stable on immunosuppressive medication for many years, prognostic factors for CRS may mirror those for immunocompetent patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant

Spillinger

Low

Smith

et al. 2021

World j. otorhinolaryngol.-head neck surg.

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“…The occurrence of halitosis is possible when the level of urea in the blood exceeds 55 mg / dl. The alkaline nature of urea and ammonia maintains an elevated pH level of saliva and bacterial biofilm, contribut-ing to the formation of tartar and reducing the risk of caries in patients with CKD [30].…”

Section: Discussionmentioning

confidence: 99%

Features of the development and course of otolaryngological diseases in patients with chronic renal insufficiency

Savchenko¹,

Avkaeva²,

Velmatova³

et al. 2023

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In the modern world, patients suffering from chronic renal insufficiency quite often also have a number of other diseases, among which otolaryngological ailments occupy far from the last place. The causes of the development of ENT diseases against the background of the development or chronic course of kidney disease usually lie in the weakening of the immune system of patients, as well as in the use of certain pharmacological complexes by the latter, which have side effects expressed in a negative effect on the functions of ENT organs. Patients who have been shown and underwent kidney transplantation are particularly at risk of developing otolaryngological diseases, since such patients need lifelong treatment to suppress the immune system and minimize the likelihood of organ rejection. A decrease in the body's defenses under certain conditions leads to the development of diseases of various natures, including otolaryngological ones. The authors believe that the otorhinolaryngological dysfunctions discussed above that have arisen in patients with CKD are usually permanent and difficult to control, have a negative impact on the quality of life of patients with CKD. For this reason, patients suffering from CKD should be regularly monitored by an otolaryngologist, undergoing regular examinations. The importance of these procedures is determined by the fact that individual otolaryngological disorders, in case of their early detection, may be reversible. In addition, correctly and timely prescribed treatment can limit the development of individual ENT pathologies.

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“…Частота острых (обострения хронических) воспалительных оториноларингологических осложнений при проведении ТГСК в литературе практически не описана. Относительно часто встречаются исследования, посвященные воспалительным заболеваниям полости носа, однако количество этих работ не превышает 2-3 десятков, выборка в самых крупных из них редко превышает 200 пациентов, а сами исследования датируются 10-20-летней давностью [11][12][13][14][15][16]. Наиболее поздние и актуальные исследования, посвященные проблеме синусита на фоне ТГСК, проводились сотрудниками НИИ ДОГиТ им.…”

Section: Rossiiskaya Otorinolaringologiyaunclassified

Prevalence of acute inflammatory otorhinolaryngological diseases in hematopoietic stem cell transplant recipients

Dolgov¹,

Karpishchenko²,

Rodneva³

et al. 2021

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The article presents the results of a study of the prevalence of acute (exacerbation of chronic) otorhinolaryngological pathology at the stages of hematopoietic stem cell transplantation (HSCT). The frequency of the studied pathology was assessed at the stage of pre-transplant screening, at the stage before graft engraftment and at the stage after graft engraftment up to 180 days. The study included 1129 cases of HSCT performed at the Raisa Gorbacheva Memorial Research Institute of Pediatric Oncology, Hematology and Transplantation from January 2017 to December 2019. The median age of the patients was 27 years (min – 0,36, max – 73,22). Allogeneic HSCT was performed in 784 (69,4%) cases, autologous HSCT in 345 (30,6%) cases. The power of the study was 0,95. A comparative analysis using the Pearson χ2 criterion revealed that infectious complications were significantly more frequent with allo-HSCT than with auto-HSCT, both at the stage before engraftment (χ2 = 21.8 at p <0.0001) and at the stage after graft engraftment (χ2 = 224,78 at p < 0.0001). It was also shown that acute symptoms of rhinosinusitis prevailed at all stages of HSCT, reaching 5,3% (95% CI 5.0% – 5,6%) at the stage before transplantation, 3,01% (95% CI 2, 8% – 3,2%) at the stage before engraftment, and 8,13% (95% CI 7,67% – 8,60%) at the stage after engraftment. At the stage before engraftment, rhinosinusitis competed with the diagnosis of acute pharyngitis, with a frequency of 34 (36,17%) and 33 (35,11%), respectively. Acute rhinosinusitis, acute rhinitis, and strep throat were the most common diagnoses at all three stages assessed. The rest of the acute inflammatory otorhinolaryngological diagnoses were observed in less than 2% of cases each. Establishing the frequency of acute otorhinolaryngological pathology at the stages of HSCT; understanding the most relevant nosologies. This allows us to focus on further study of the factors of their development, prevention and treatment.

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The Burden of Sinusitis in Hematologic Transplant Patients: A National Perspective

Cited by 3 publications

References 20 publications

Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant

Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant

Features of the development and course of otolaryngological diseases in patients with chronic renal insufficiency

Prevalence of acute inflammatory otorhinolaryngological diseases in hematopoietic stem cell transplant recipients

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