The Burden of Sickle Cell Disease in Saudi Arabia: A Single-Institution Large Retrospective Study

Zuair, Amerah Bin; Aldossari, Sheikhah; Alhumaidi, Rand; Alrabiah, Maha; Alshabanat, Abdulmajeed

doi:10.2147/ijgm.s393233

Cited by 9 publications

(8 citation statements)

References 24 publications

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“…Despite the fact that healthcare is free of charge in Saudi Arabia, SCD has a significant economic burden on Saudi society as well as an impact on the patient’s quality of life. 17 Therefore, launching a premarital screening program is justified in this area. 7 , 10 …”

Section: Discussionmentioning

confidence: 99%

“…Despite the fact that healthcare is free of charge in Saudi Arabia, SCD has a significant economic burden on Saudi society as well as an impact on the patient's quality of life. 17 Therefore, launching a premarital screening program is justified in this area. 7,10 In our study, we found that the majority of the participants were aware of SCD's mode of inheritance and pain as the main (and frequent) presentation of the disease.…”

Section: Discussionmentioning

confidence: 99%

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Sickle Cell Disease Knowledge and Reproductive Decisions: A Saudi Cross-Sectional Study

Alsalman¹,

Alhamoud²,

Alabdullah³

et al. 2023

PPA

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Background and Aim Sickle cell disease (SCD) is an autosomal recessive disorder. Decisions following premarital screening results might be influenced by several factors. Thus, this study aims to assess the knowledge and beliefs toward SCD and reproductive decisions. Material and Methods A cross-sectional study was conducted among adults in the eastern province of Saudi Arabia. Data was collected using a web-based questionnaire. Participants were divided into two groups based on their knowledge scores. Results A total of 390 participants were recruited with a mean age of 28.6 years. The majority (90.5%) of participants had general knowledge about the disease mode of inheritance however, 66.9% had poor knowledge about the disease overall. Regarding knowledge level, there was no statistically significant difference between the non-healthy group (diseased and carrier) and healthy participants (P=0.304). Moreover, the participants’ decisions about choosing future partners were more likely to be affected among those with prior knowledge about the disease (p=0.008). However, 152 (91.6%) male participants with prior knowledge would change their decision about selecting a future partner compared to 225 (92.4%) female participants. Regarding reproduction, only 38.5% of participants were aware of in vitro fertilization (IVF) as an assistive reproductive technology. Furthermore, female participants believed that IVF is a way to have healthy babies and would consider it despite the cost more than male participants (p=0.0001, p=0.007 respectively). Conclusion SCD is an inherited disease with economic, physical, and psychological burdens. However, curative options are costly, and hence, prevention is key. Therefore, healthcare decision-makers should consider implementing policies to minimize the financial burden that may still affect society despite the availability of free medical care. This study warrants extensive community-based education programs that may contribute toward cost savings. It also highlights the importance of premarital counselling for disease and carrier people including alternative reproduction options.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sickle Cell Disease Knowledge and Reproductive Decisions: A Saudi Cross-Sectional Study

Alsalman¹,

Alhamoud²,

Alabdullah³

et al. 2023

PPA

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“…The average utilization of healthcare facilities by the enrolled SCD patients was defined as one admission per year and four ED visits per year. 3 Based on this, two categories were established. The high utilization group whose number of admissions or ED visits per year exceeded the previously defined average, and the low utilization group had admissions or ED visits that were equal to or lower than the defined average.…”

Section: Methodsmentioning

confidence: 99%

“…A retrospective study showed that Saudi patients with SCD have a high rate of emergency department (ED) visits, admissions, and readmissions. 3 Similarly, another study on the Saudi SCD population showed that 64.3% had three or more ED visits related to SCD over six months. It was found that male gender, being married, and having a university degree are risk factors for a higher rate of ED visits.…”

Section: Introductionmentioning

confidence: 95%

Predictive Factors for 30-Day Readmission and Increased Healthcare Utilization in Sickle Cell Disease Patients: A Single-Center Comparative Retrospective Study

Alshabanat,

Alrabiah,

Bin Zuair

et al. 2024

IJGM

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Background SCD poses a significant healthcare burden. Understanding the factors contributing to high healthcare utilization and readmissions is crucial for improving the quality of care provided. Methods This retrospective comparative observational study was conducted at King Saud University Medical City and included 160 SCD patients. A comparison was made between patients with no readmission and patients with at least one 30-day readmission. Another comparison was done between high healthcare-utilizing patients and low healthcare-utilizing patients. A regression model for 30-day readmission prediction was created. Results Readmission was significantly higher in patients using opioids, following up with pain clinics, and having a history of AVN (p= 0.002, p=0.028 and p=0.025 respectively). Higher healthcare utilization was associated with older age, smoking, use of opioids and GABA analogs, and psychiatric illnesses, including depression, substance use disorder, and anxiety. Predictors of 30-day readmission were hydroxyurea use (odds ratio, 2.819 [95% CI,1.082 to 7.34], p = 0.034), follow-up with pain management clinics (odds ratio, 2.248 [95% CI,1.547 to 3.266], p = 0.001), and SCD genotype (SS genotype) (odds ratio, 1.754 [95% CI,1.012 to 3.042], p = 0.045). Using the Paracetamol/Codeine combination significantly reduced the likelihood of readmission within 30 days of discharge. Conclusion This study identified factors associated with 30-day readmission rate and high healthcare utilization among SCD patients. Strategies to reduce readmissions may include specialized SCD clinics, educational programs for patients, improved physician awareness of mental health screening, and further research on the impact of opioid use. Limitations include retrospective nature, single-center design, reliance on self-reported data, and exclusion of critically ill patients. However, despite the limitations, this study could lay a foundation for future projects aiming to optimize care and outcomes for patients living with SCD.

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“…According to the Saudi Premarital Screening Program, sickle cell gene prevalence is estimated to be 4.2% for sickle cell trait and 0.26% for SCD in the adult population. The Eastern province has the highest prevalence rates, approximately 17% for sickle cell trait and 1.2% for SCD [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Laboratory predictors of sickle cell disease severity: a cross-sectional study

Alsalman

2024

JMedLife

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The Burden of Sickle Cell Disease in Saudi Arabia: A Single-Institution Large Retrospective Study

Cited by 9 publications

References 24 publications

Sickle Cell Disease Knowledge and Reproductive Decisions: A Saudi Cross-Sectional Study

Sickle Cell Disease Knowledge and Reproductive Decisions: A Saudi Cross-Sectional Study

Predictive Factors for 30-Day Readmission and Increased Healthcare Utilization in Sickle Cell Disease Patients: A Single-Center Comparative Retrospective Study

Laboratory predictors of sickle cell disease severity: a cross-sectional study

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