The burden of respiratory viral disease in hospitalized children in Paris

El-Hajje, Marie-Joelle; Lambe, Cécile; Moulin, F.; Suremain, N. de; Pons-Catalano, Charlotte; Raymond, Josette; Lebon, Pierre; Gendrel, D.

doi:10.1007/s00431-007-0529-5

Cited by 11 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our retrospective study, we analysed demographic, seasonal and epidemiological factors, as well as clinical manifestations of both RSV and non-RSV bronchiolitis in infants and children under the age of two years, with the course of the disease severe enough to require hospitalisation. The aetiology of bronchiolitis in the children studied was RSV infection in only 33% of them, in contrast to other studies reporting RSV aetiology in as many as [1,10], and ranging widely from 17.5% [12] to 80.8% [13] in epidemiological studies that included patients aged from one to 16 years. The practice in our hospital, on admission, is to perform a nasopharyngeal aspirate, and an immunofluorescent test is routinely performed in children to define the aetiology of ALRI; however, its sensitivity and specificity are a matter of debate [14,15] and may be, at least in part, responsible for false negative results.…”

Section: Discussioncontrasting

confidence: 72%

RSV versus non-RSV bronchiolitis in infants and young children – the bedside characteristics of one epidemic season

Szczawińska-Popłonyk¹,

Komasińska²,

Tąpolska-Jóźwiak³

et al. 2019

polp

View full text Add to dashboard Cite

Introduction: Acute lower respiratory infection (ALRI), comprising both bronchiolitis and pneumonia, is a global leading cause of morbidity and hospital admissions of infants and young children, with respiratory syncytial virus (RSV) being a major viral cause. Guidelines recommend a clinical diagnosis of bronchiolitis but do not advise how to distinguish between different viral aetiologies using clinical, laboratory, and radiological criteria. Aim of the study: The aim of this study was to provide clinical data that characterise RSV and non-RSV aetiology of bronchiolitis for the purpose of better defining the correlations between the viral aetiology and clinical characteristics as well as the risk factors of severe disease. Material and methods: We retrospectively reviewed 135 records of 116 infants and young children who were hospitalised due to bronchiolitis during one infectious season. A detailed analysis of patients' medical history, clinical course of bronchiolitis, viral aetiology of infection, basic laboratory tests, as well as radiological findings was performed. Results: Children with RSV bronchiolitis more frequently demonstrated obstruction of the lower airways manifesting with diminished breath sounds and crackles on auscultation and more severe course of the disease than non-RSV patients, defined as hypoxaemia and desaturation, the need for supplemental oxygen, longer duration of oxygen therapy, and a longer hospitalisation. Conclusions: Clinical symptoms of obstruction of lower airways are more frequent and more severe in RSV than in non-RSV bronchiolitis. Because basic laboratory tests and chest radiographs are not helpful in distinguishing between RSV and non-RSV bronchiolitis, their use in uncomplicated cases should be limited. Therefore, careful clinical assessment and monitoring of children with bronchiolitis is of utmost importance in predicting the course of ALRI and in the implication of therapeutic decisions.

show abstract

Section: Discussioncontrasting

confidence: 72%

RSV versus non-RSV bronchiolitis in infants and young children – the bedside characteristics of one epidemic season

Szczawińska-Popłonyk¹,

Komasińska²,

Tąpolska-Jóźwiak³

et al. 2019

polp

View full text Add to dashboard Cite

show abstract

“…Les infections respiratoires sont fréquentes chez l'enfant, et la plupart d'entre elles sont d'origine virale [1,2]. Dans les pays à climat tempéré, elles surviennent principalement en hiver [2].…”

Section: Introductionunclassified

Étude prospective de l’écologie virale hivernale dans un service de réanimation pédiatrique

Mortamet

Morello

Jokic

et al. 2015

Archives de Pédiatrie

View full text Add to dashboard Cite

show abstract

“…RSV is one of the most important causes of infant mortality and hospitalization worldwide and causes more cases of viral pneumonia in infants than any other virus [3,4,5]. It is highly transmissible, spreading through communities rapidly and infecting most of the population by the age of one [6].…”

Section: Introductionmentioning

confidence: 99%

Innate and Adaptive Immune Response to Pneumonia Virus of Mice in a Resistant and a Susceptible Mouse Strain

Watkiss

Shrivastava

Arsic

et al. 2013

Viruses

View full text Add to dashboard Cite

Respiratory syncytial virus (RSV) is the leading cause of infant bronchiolitis. The closely related pneumonia virus of mice (PVM) causes a similar immune-mediated disease in mice, which allows an analysis of host factors that lead to severe illness. This project was designed to compare the immune responses to lethal and sublethal doses of PVM strain 15 in Balb/c and C57Bl/6 mice. Balb/c mice responded to PVM infection with an earlier and stronger innate response that failed to control viral replication. Production of inflammatory cyto- and chemokines, as well as infiltration of neutrophils and IFN-γ secreting natural killer cells into the lungs, was more predominant in Balb/c mice. In contrast, C57Bl/6 mice were capable of suppressing both viral replication and innate inflammatory responses. After a sublethal infection, PVM-induced IFN-γ production by splenocytes was stronger early during infection and weaker at late time points in C57Bl/6 mice when compared to Balb/c mice. Furthermore, although the IgG levels were similar and the mucosal IgA titres lower, the virus neutralizing antibody titres were higher in C57Bl/6 mice than in Balb/c mice. Overall, the difference in susceptibility of these two strains appeared to be related not to an inherent T helper bias, but to the capacity of the C57Bl/6 mice to control both viral replication and the immune response elicited by PVM.

show abstract

The burden of respiratory viral disease in hospitalized children in Paris

Cited by 11 publications

References 5 publications

RSV versus non-RSV bronchiolitis in infants and young children – the bedside characteristics of one epidemic season

RSV versus non-RSV bronchiolitis in infants and young children – the bedside characteristics of one epidemic season

Étude prospective de l’écologie virale hivernale dans un service de réanimation pédiatrique

Innate and Adaptive Immune Response to Pneumonia Virus of Mice in a Resistant and a Susceptible Mouse Strain

Contact Info

Product

Resources

About