The Burden of Pathological Neonatal Jaundice and Its Determinants in Ethiopia: Systematic Review and Meta-Analysis

Tsehay, Binalfew; Afework, Mekbeb

doi:10.1177/09732179231164520

Cited by 1 publication

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neonatal hyperbilirubinemia is a common clinical problem encountered during the neonatal period, especially in the first week of life [1]. Between 8% and 11% of newborns experience hyperbilirubinemia.…”

Section: Introductionmentioning

confidence: 99%

The association of oxidative stress of neonatal hyperbilirubinemia and vitamin E supplementation

Hafez Ahmed,

Saad,

Gadalla

et al. 2024

ceh

View full text Add to dashboard Cite

Aim of the study: Jaundice in newborns is a sign of skin and sclera pigmentation. Hyperbilirubinemia and these phenomena do, however, have a relationship. According to many clinical studies, elevated blood bilirubin and low vitamin E (VE) levels in newborns are associated. The aim of the study was to investigate the association of oxidative stress of neonatal hyperbilirubinemia in patients who underwent phototherapy with additional vitamin E supplementation (25 mg/kg/day over the course of three days) and patients without additional vitamin E. Material and methods: A set of 100 neonatal indirect hyperbilirubinemia patients was enrolled at neonatal intensive care units (NICUs) of the pediatric departments at Al Azhar University Hospitals during the period from February 2021 to October 2022 after obtaining signed written informed consent of all neonates' parents with an explanation of the aim of study. Results: Significant differences were found between the studied groups regarding serum bilirubin on the third day of admission (p = 0.039). Patients who were treated with vitamin E had lower serum bilirubin on the third day of admission (8.25 ±3.41) than the control group (11.66 ±3.22). Also, among the VE group, serum bilirubin was significantly decreased on the third day of admission (8.25 ±3.41) compared to zero days of admission (14.10 ±4.39) (p = 0.041). Conclusions: Vitamin E supplementation has an important role in treatment of indirect hyperbilirubinemia in neonates. Early administration of vitamin E in preterm neonates resulted in a significant decrease of serum bilirubin and increased total antioxidant capacity. Vitamin E supplementation in full term decreased the duration of phototherapy.

show abstract

Section: Introductionmentioning

confidence: 99%