The burden of obesity in asthma and COPD: Role of adiponectin

Bianco, Andrea; Nigro, Ersilia; Monaco, Maria Ludovica; Matera, Maria Gabriella; Scudiero, Olga; Mazzarella, Gennaro; Daniele, Aurora

doi:10.1016/j.pupt.2017.01.004

Cited by 64 publications

(62 citation statements)

References 58 publications

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“…Furthermore, in human epithelial cells, RELMb induced increased proliferation, mucin and growth factor production, suggesting a potential contribution to airway remodeling. Interestingly adiponectin inhibits some effect of resistin [8,26,27]. Increasing evidence indicates that resistin plays an important regulatory role in insulin resistance, and several pathological processes including asthma, cardiovascular disease, and inflammatory bowel disease [7,24,[26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of adipokines in children with cystic fibrosis

Machura

Szczepańska²,

Świętochowska³

et al. 2015

Endokrynologia Polska

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Section: Discussionmentioning

confidence: 99%

Evaluation of adipokines in children with cystic fibrosis

Machura

Szczepańska²,

Świętochowska³

et al. 2015

Endokrynologia Polska

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“…In particular, the intercorrelation between adipose tissue and the lung has become evident as the involvement of adiponectin has been demonstrated in several lung diseases such as Chronic Obstructive Pulmonary Disease (COPD), emphysema, and cancer [34]. In fact, with specific regard to COPD, a low-grade inflammatory state has been demonstrated [35][36][37]. Moreover, increasing evidence suggests that adiponectin also exerts a crucial role in the vascular endothelium, maintaining vascular homeostasis and protecting against vascular dysfunctions.…”

Section: Adiponectin Function In Lung Infectionsmentioning

confidence: 99%

Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work

Messina

Polito

Monda

et al. 2020

IJMS

157

150

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Background: On the 31 December 2019, the World Health Organization (WHO) was informed of a cluster of cases of pneumonia of unknown origin detected in Wuhan City, Hubei Province, China. The infection spread first in China and then in the rest of the world, and on the 11th of March, the WHO declared that COVID-19 was a pandemic. Taking into consideration the mortality rate of COVID-19, about 5-7%, and the percentage of positive patients admitted to intensive care units being 9-11%, it should be mandatory to consider and take all necessary measures to contain the COVID-19 infection. Moreover, given the recent evidence in different hospitals suggesting IL-6 and TNF-α inhibitor drugs as a possible therapy for COVID-19, we aimed to highlight that a dietary intervention could be useful to prevent the infection and/or to ameliorate the outcomes during therapy. Considering that the COVID-19 infection can generate a mild or highly acute respiratory syndrome with a consequent release of pro-inflammatory cytokines, including IL-6 and TNF-α, a dietary regimen modification in order to improve the levels of adiponectin could be very useful both to prevent the infection and to take care of patients, improving their outcomes.

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“…It has been suggested that adipose tissue may talk to other organs through endocrine functions; specifically, the crosstalk between adipose tissue and lung may be mediated by adipokines [32]. Thus, the serum levels of adipokines are elevated in patients affected by COPD, independently of their smoking habit, and positively correlate with disease severity and ratio of exacerbation [33,34].…”

Section: Copd and Obesitymentioning

confidence: 99%

Metabolic Disorder in Chronic Obstructive Pulmonary Disease (COPD) Patients: Towards a Personalized Approach Using Marine Drug Derivatives

et al. 2017

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Metabolic disorder has been frequently observed in chronic obstructive pulmonary disease (COPD) patients. However, the exact correlation between obesity, which is a complex metabolic disorder, and COPD remains controversial. The current study summarizes a variety of drugs from marine sources that have anti-obesity effects and proposed potential mechanisms by which lung function can be modulated with the anti-obesity activity. Considering the similar mechanism, such as inflammation, shared between obesity and COPD, the study suggests that marine derivatives that act on the adipose tissues to reduce inflammation may provide beneficial therapeutic effects in COPD subjects with high body mass index (BMI).

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The burden of obesity in asthma and COPD: Role of adiponectin

Cited by 64 publications

References 58 publications

Evaluation of adipokines in children with cystic fibrosis

Evaluation of adipokines in children with cystic fibrosis

Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work

Metabolic Disorder in Chronic Obstructive Pulmonary Disease (COPD) Patients: Towards a Personalized Approach Using Marine Drug Derivatives

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