The burden of nosocomial staphylococcus aureus bloodstream infection in South Korea: a prospective hospital-based nationwide study

Kim, Chung-Jong; Kim, Hong Bin; Oh, Myoung‐don; Kim, Yun-Hee; Kim, Arim; Oh, Sung-Hee; Song, Kyoung-Ho; Kim, Eu Suk; Cho, Yong Kyun; Choi, Young Hwa; Park, Jin-Yong; Kim, Baek-Nam; Kim, Nam Joong; Kim, Kye-Hyung; Lee, Eun Jung; Jun, Jae‐Bum; Kim, Young Keun; Kiem, S.; Choi, Hee Jung; Choo, Eun Ju; Sohn, Kyung Mok; Lee, Shinwon; Chang, Hyun Ha; Bang, Ji Hwan; Lee, Su Jin; Lee, Jae Hoon; Park, Seong Yeon; Jeon, Min Hyok; Yun, Na Ra

doi:10.1186/s12879-014-0590-4

Cited by 38 publications

(29 citation statements)

References 29 publications

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“…This is consistent with Chakrakodi et al in the Tertiary Care Indian Hospital [26]. However, this is higher than is previously reported in S. Korea [28], Australia [8] and India [36]. Probable attributes are suggested to be the inappropriate use of antibiotic or inadequate drug dosage during treatment.…”

Section: Discussionsupporting

confidence: 91%

Highly Resistant Staphylococcus aureus Isolated from Patients Attending a Tertiary Hospital, South Western Uganda

Baguma¹,

Tibyange

Owalla

et al. 2019

MRJI

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Section: Discussionsupporting

confidence: 91%

Highly Resistant Staphylococcus aureus Isolated from Patients Attending a Tertiary Hospital, South Western Uganda

Baguma¹,

Tibyange

Owalla

et al. 2019

MRJI

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“…This may be partly due to the better clinical outcomes in pediatric MRSA bacteremia than in adult cases. Indeed, overall 30-day mortality associated with MRSA bacteremia was 11.1% in this study, which was much lower than that in adult patients (13). A recent prospective cohort study reported a 25.6%, 30-day mortality of invasive MRSA infections in a Korean population with median age 64 years (14).…”

Section: Discussioncontrasting

confidence: 58%

Impact of Initial Vancomycin Trough Concentration on Clinical and Microbiological Outcomes of Methicillin-ResistantStaphylococcus aureusBacteremia in Children

2017

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It is important to use vancomycin in a proper manner to ensure optimal drug exposure. Despite extensive use of vancomycin in children, studies on its optimal trough concentration (Ctrough) in the pediatric population remained rare. This retrospective study included children < 18 years old with culture-confirmed methicillin-resistant Staphylococcus aureus (MRSA) bacteremia who were hospitalized in our institute from January 2010 to April 2014. Clinical characteristics, initial vancomycin dose, Ctrough and clinical/microbiological outcomes were retrospectively collected from medical records. Forty-six MRSA bacteremia cases occurring to the patients with a mean age of 22.0 ± 46.9 months were included and all of them were healthcare-associated. Severe diseases requiring intensive care unit (ICU) stay, mechanical ventilation and/or resulting in death were observed in 57.8% (26/45); all-cause 30-day fatality was 11.1% (5/45). An initial Ctrough ≥ 15 μg/mL was achieved in only 4 (8.7%) cases with an average vancomycin dosage of 40.6 ± 7.9 mg/kg/day. Persistent bacteremia at 48 hours after initiation of vancomycin was observed more frequently in children with initial Ctrough < 10 μg/mL than in those with Ctrough ≥ 10 μg/mL (P = 0.032). However, there was no statistically significant difference between the two groups in terms of 30-day mortality and recurrent bacteremia (P = 0.899, and P = 0.754, respectively). Although initial Ctrough may be a useful parameter for minimizing early microbiological failure, it does not predict 30-day fatality or recurrence in pediatric MRSA bacteremia. Further prospective data on vancomycin dosing are needed to find the optimal drug exposure and clarify its impact on clinical outcomes in pediatric populations.

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“…The hospital mortality rate between MRSA and MSSA inpatients has long been controversial, and the results in some studies are inconsistent 12,16,17,20,33,40,45,46 . It was reported that patients with MRSA pneumonia infections had a higher mortality rate than those with MSSA (P < 0.001) 13 .…”

Section: Discussionmentioning

confidence: 99%

Clinical and economic impact of methicillin-resistant Staphylococcus aureus: a multicentre study in China

Zhen

Lundborg

Zhang

et al. 2020

Sci Rep

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Methicillin-resistant Staphylococcus aureus (MRSA) has become a serious threat to global health.In China, the proportion of S. aureus isolates that were MRSA was 44.6% in 2014. The clinical and economic impact of MRSA in China remains largely uninvestigated. This study aims to compare the differences in hospital costs, length of hospital stay, and hospital mortality rate between MRSA and methicillin-susceptible S. aureus (MSSA) colonization or infection and between MRSA cases and those without an S. aureus infection. A retrospective and multicentre study was conducted in four tertiary hospitals in China between 2013 and 2015. Inpatient characteristics and hospital costs were collected from electronic medical records. We conducted propensity score matching (PSM) to eliminate selection bias by balancing the potential confounding variables between the two groups. The main indicators included hospital costs, length of hospital stay, and hospital mortality rate. A total of 1,335 inpatients with MRSA, 1,397 with MSSA, and 33,606 without an S. aureus infection were included. PSM obtained 954 and 1,313 pairs between the MRSA and MSSA groups and between the MRSA and S. aureus-free groups, respectively. After PSM, MRSA colonization or infection is associated with an increased total hospital cost ranging from $3,220 to $9,606, an excess length of hospital stay of 6 days-14 days, and an attributable hospital mortality rate of 0-3.58%. Between the MRSA and MSSA groups, MRSA colonization or infection was significantly associated with a higher total hospital cost and longer length of hospital stay among survivors but not among non-survivors; however, there were no differences in the hospital mortality rate between these two groups. Between the MRSA and the S. aureus-free groups, MRSA colonization or infection was significantly associated with an increased total hospital cost, a prolonged length of hospital stay and a higher hospital mortality rate among both survivors and non-survivors. It is critical to quantify the clinical and economic impact of MRSA to justify resource allocation for the development of strategies to improve clinical outcomes and to reduce the economic burden.Staphylococcus aureus is an important gram-positive bacterium in both community-and health-care-associated infections and can be resistant or susceptible to the usual antibiotics used to treat it (oxacillin or cefoxitin), namely, methicillin-resistant S. aureus (MRSA) or methicillin-susceptible S. aureus (MSSA), respectively 1,2 . MRSA has become a serious threat to global health and is responsible for a range of infections, from skin and wound infections to pneumonia and bloodstream infections. It is commonly associated with significant morbidity, hospital mortality, length of stay and economic burden 1 . In all World Health Organization (WHO) regions, the overall proportion of S. aureus isolates that were MRSA exceeded 20% and even exceeded 80% in some reports 3 . In China, there was a marked decrease in the proportion of MRSA from 69% in 2005 to 44.6...

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The burden of nosocomial staphylococcus aureus bloodstream infection in South Korea: a prospective hospital-based nationwide study

Cited by 38 publications

References 29 publications

Highly Resistant Staphylococcus aureus Isolated from Patients Attending a Tertiary Hospital, South Western Uganda

Highly Resistant Staphylococcus aureus Isolated from Patients Attending a Tertiary Hospital, South Western Uganda

Impact of Initial Vancomycin Trough Concentration on Clinical and Microbiological Outcomes of Methicillin-ResistantStaphylococcus aureusBacteremia in Children

Clinical and economic impact of methicillin-resistant Staphylococcus aureus: a multicentre study in China

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