The burden of multiple sclerosis in Japan

Nohara, Chiyoko; Hase, Masakazu; Liebert, Ryan; Wu, Ning

doi:10.1080/13696998.2017.1373653

Cited by 9 publications

(11 citation statements)

References 25 publications

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“…In the present study, patients with MS exhibited significantly worse health status and higher work productivity loss, health care resource use, and costs (direct and indirect), compared with controls without MS, even after adjusting for confounders. The study findings suggest that MS negatively affects health status, which is consistent with earlier research 12,16,31. For example, an observational study using Medical Expenditure Panel Survey data reported worse health status, as mea sured via PCSs and MCSs, among those with MS, compared with those without MS in the general population 31.…”

Section: Discussionsupporting

confidence: 89%

“…For example, an observational study using Medical Expenditure Panel Survey data reported worse health status, as mea sured via PCSs and MCSs, among those with MS, compared with those without MS in the general population 31. Similarly, cross-sectional observational studies conducted in US and Japan reported poorer health status, with lower PCS, MCS, and SF-6D health state utility scores among patients with MS, compared with controls 12,16…”

Section: Discussionmentioning

confidence: 99%

“…Very few studies have assessed the health-related burden of MS in Japan, and only one recent study evaluated economic outcomes from this region 16. As such, the burden of MS in Japan is not yet well understood, and further clarification is necessary.…”

Section: Introductionmentioning

confidence: 99%

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Health-related outcomes, health care resource utilization, and costs of multiple sclerosis in Japan compared with US and five EU countries

Yamabe¹,

DiBonaventura²,

Pashos³

2019

CEOR

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PurposeMultiple sclerosis (MS) imposes a huge burden on patients. This study examined the relationship between MS and health-related and economic burden in Japan; secondarily, health status was compared across patients with MS in Japan, US, and five European Union (5EU) countries (France, Germany, Italy, Spain, and UK).MethodsA retrospective cross-sectional study was conducted using self-reported data from 2009 to 2014 Japan National Health and Wellness Survey (n=145,759). Health status, work productivity loss, activity impairment, health care resource utilization, and annual costs associated with MS (n=85) were compared with controls without MS (n=145,674). Propensity score matching and multivariable linear regressions determined the effect of MS after controlling for confounders. Health status in Japan was also compared with that of 5EU (n=62) and US (n=67) patients with MS.ResultsPatients with MS in Japan reported significantly worse health status via mental component summary score (MCS; 40.1 vs 45.8) and physical component summary score (PCS; 41.4 vs 51.2) and health state utility scores (0.63 vs 0.74; all P<0.001). They also reported more absenteeism (12.0% vs 3.7%), presenteeism (33.8% vs 19.8%), overall work impairment (40.9% vs 21.6%), and activity impairment (43.6% vs 24.0%), with higher indirect costs (¥2,040,672/US $20,102 vs ¥1,076,306/US$10,603) than controls (all P<0.001). Patients with MS reported higher resource use, including provider visits (8.0 vs 4.7), emergency room visits (0.03 vs 0.1), and hospitalizations (2.7 vs 0.69) in the past 6 months, with higher direct costs (¥3,670,906/US$36,162 vs ¥986,099/US$9,714) than controls (all P<0.001). Finally, Japanese patients with MS reported lower MCSs and higher PCSs than their US and 5EU counterparts.ConclusionMS in Japan is associated with poor health status and high work productivity loss, resource use, and costs, underscoring the need for improved treatment, especially vis-à-vis mental health, when comparing Japanese patients with their 5EU and US counterparts.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Health-related outcomes, health care resource utilization, and costs of multiple sclerosis in Japan compared with US and five EU countries

Yamabe¹,

DiBonaventura²,

Pashos³

2019

CEOR

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“…29 Also, the respective proportion were very different, for example in Japan absenteeism was 12% in MS and 3.7% in general population, whereas presenteeism-33.8% and 19.8%, respectively. 19 Similarly, in another Japanese study, 33 absenteeism proportions were 17.5% and 5.57%, respectively, and for presenteeism-38.11 and 21.62%, respectively.…”

Section: Work Ability-related Outcomesmentioning

confidence: 72%

“…37 However, the exact way of measurement may differ, for example Castelo-Branco et al calculated labour-force absenteeism as the mean annual prevalence and number of sick-leave and disability pension days, 38 whereas Ivanova et al looked at medically related absenteeism as work absences due to the use of medical services. 29 However, the two Japanese studies, 19,33 included in our review, did not specifically defined these types of outcomes, but did report higher proportions of both absenteeism and presenteeism in MS patients than controls. Glanz et al suggest that absenteeism and presenteeism may be measuring separate dimensions of the impact of health problems on work productivity.…”

Section: Discussionmentioning

confidence: 95%

Socioeconomic consequences of multiple sclerosis—A systematic literature review

2021

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Approximately 2.8 million people worldwide are affected with multiple sclerosis (MS)-a chronic demyelinating and neurodegenerative disease of the central nervous system with increasing prevalence. 1,2 It continues to be a challenging and disabling condition, predominantly affecting individuals in their early life, and has an impact functionally, financially and on quality of life. 3 Moreover, MS poses a high cost to society in terms of both direct and indirect costs. 4,5 In the research on health-related social inequalities, two principally different relationships may be distinguished between social factors and health: the influence of adverse socioeconomic conditions on health and the reverse-that illness has an adverse effect on socioeconomic circumstances. 6 Much of the recent research on social factors and health has focussed on the aetiological role of socioeconomic conditions; however, chronic illness, such as MS, may have social and economic consequences, for example unemployment or exclusion from the labour market, and financial difficulties. 6,7 Previously published reviews in the field focus only on particular socioeconomic outcomes, for example employment status, in a nonsystematic manner. 8 Thus, there is a need for a systematic approach.A literature review on factors related to difficulties with employment

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People Diagnosed with Myasthenia Gravis have Lower health-related quality of life and Need More Medical and Caregiver Help in Comparison to the General Population: Analysis of Two Observational Studies

Dewilde,

Phillips,

Paci

et al. 2023

Adv Ther

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The burden of multiple sclerosis in Japan

Abstract: Results suggest MS in Japan is associated with poorer HRQoL and greater work and activity impairment, healthcare resource use, and costs. Improved MS management could benefit both patients and society.

Cited by 9 publications

References 25 publications

Health-related outcomes, health care resource utilization, and costs of multiple sclerosis in Japan compared with US and five EU countries

Health-related outcomes, health care resource utilization, and costs of multiple sclerosis in Japan compared with US and five EU countries

Socioeconomic consequences of multiple sclerosis—A systematic literature review

People Diagnosed with Myasthenia Gravis have Lower health-related quality of life and Need More Medical and Caregiver Help in Comparison to the General Population: Analysis of Two Observational Studies

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