The burden of metabolic risk factors in North Africa and the Middle East, 1990–2019: findings from the Global Burden of Disease Study

Malekpour, Mohammad‐Reza; Abbasi‐Kangevari, Mohsen; Ghamari, Seyyed‐Hadi; Khanali, Javad; Heidari‐Foroozan, Mahsa; Moghaddam, Sahar Saeedi; Azangou‐Khyavy, Mohammadreza; Rezazadeh-Khadem, Sahba; Rezaei, Negar; Shobeiri, Parnian; Esfahani, Zahra; Rezaei, Nazila; Aali, Amirali; Abd‐Elsalam, Sherief; Abdoun, Meriem; Absalan, Abdorrahim; Abu‐Gharbieh, Eman; Abu-Rmeileh, Niveen M E; Abu‐Zaid, Ahmed; Ahmadi, Ali; Ahmadi, Sepideh; Ahmed, Ayman; Rashid, Tarik Ahmed; Ajami, Marjan; Akbarzadeh-Khiavi, Mostafa; Hamad, Hanadi Al; Alalwan, Tariq A.; AlHabib, Khalid F.; Alimohamadi, Yousef; Alipour, Vahid; Aljunid, Syed Mohamed; Alomari, Mahmoud A.; Alqahatni, Saleh A.; Al-Raddadi, Rajaa; Dehkordi, Javad Javad Aminian; Amir-Behghadami, Mehrdad; Amiri, Sohrab; Anvari, Davood; Arabloo, Jalal; Arulappan, Judie; Arumugam, Ashokan; Aryan, Zahra; Athar, Mohammad; Athari, Seyyed Shamsadin; Avan, Abolfazl; Azadnajafabad, Sina; Azari, Samad; Azizi, Hosein; Baghcheghi, Nayereh; Bagheri, Nader; Bagherieh, Sara; Baltatu, Ovidiu Constantin; Bhagavathula, Akshaya Srikanth; Bhojaraja, Vijayalakshmi S; Bouaoud, Souad; Butt, Muhammad Hammad; Campos, Luciana Aparecida; Chitheer, Abdulaal; Soltani, Reza Darvishi Cheshmeh; Darwesh, Aso Mohammad; Djalalinia, Shirin; Dodangeh, Milad; Zaki, Maysaa El Sayed; Elbarazi, Iffat; Elhadi, Muhammed; El‐Huneidi, Waseem; Ezzeddini, Rana; Fareed, Mohammad; Farrokhpour, Hossein; Fatehizadeh, Ali; Galali, Yaseen; Ghaderi, Amir; Ghafourifard, Mansour; Nour, Mohammad Ghasemi; Ghashghaee, Ahmad; Gholamalizadeh, Maryam; Goleij, Pouya; Golitaleb, Mohamad; Habibzadeh, Parham; Hafezi-Nejad, Nima; Halwani, Rabih; Hasani, Hamidreza; Hashemian, Maryam; Hassan, Amr; Hassanipour, Soheil; Hassankhani, Hadi; Hezam, Kamal; Homayounfar, Reza; Hosseini, Seyed Kianoosh; Hosseini, Kaveh; Hosseinzadeh, Mehdi; Hoveidamanesh, Soodabeh; Jaafari, Jalil; Jahrami, Haitham; Jamshidi, Elham; Javaheri, Tahereh; Jayapal, Sathish Kumar; Kabir, Ali; Karimi, Amirali; Kaydi, Neda; Keykhaei, Mohammad; Khader, Yousef; Khafaie, Morteza Abdullatif; Khan, Moien AB; Khan, Kashif Ullah; Khan, Yusra H.; Khatatbeh, Moawiah; Kompani, Farzad; Koohestani, Hamid Reza; Kuddus, Mohammed; Lasrado, Savita; Lee, Sang-woong; Mahjoub, Soleiman; Mahmoodpoor, Ata; Mahmoudi, Elham; Rad, Elaheh Malakan; Malih, Narges; Malik, Ahmad Azam; Mallhi, Tauqeer Hussain; Manla, Yosef; Mansouri, Borhan; Mansournia, Mohammad Alì; Mardi, Parham; Marjani, Abdoljalal; Masoudi, Sahar; Nasab, Entezar Mehrabi; Menezes, Ritesh G.; Mevsim, Vildan; Mohammad, Yousef; Mohammadi, Mokhtar; Mohammadi, Esmaeil; Mohammadifard, Noushin; Mohammed, Arif A.; Momtazmanesh, Sara; Montazeri, Fateme; Moradi, Maryam; Moradi‐Lakeh, Maziar; Morovatdar, Negar; Murray, Christopher J L; Natto, Zuhair S.; Nejadghaderi, Seyed Aria; Nowroozi, Ali; Oladnabi, Morteza; Bali, Ahmed Omar; Omer, Emad; Toroudi, Hamidreza Pazoki; Pezzani, Raffaele; Langroudi, Ashkan Pourabhari; Rafiei, Sima; Rahimi, Mehran; Rahimi-Movaghar, Vafa; Rahmani, Shayan; Rahmani, Amir Masoud; Rahmanian, Vahid; Rao, Chythra R; Rashedi, Sina; Rashidi, Mohammad‐Mahdi; Rawassizadeh, Reza; Redwan, Elrashdy Moustafa Mohamed; Rezaee, Malihe; Rezaei, Maryam; Riahi, Seyed Mohammad; Roshandel, Gholamreza; Saad, Aly; Saber-Ayad, Maha; Sabour, Siamak; Sabzmakan, Leila; Saddik, Basema; Sadeghi, Erfan; Sadeghian, Saeid; Sahebkar, Amirhossein; Saki, Morteza; Salahi, Saina; Salahi, Sarvenaz; Farrokhi, Amir Salek; Salem, Marwa Rashad; Salimzadeh, Hamideh; Samy, Abdallah M.; Sarrafzadegan, Nizal; Sathian, Brijesh; Shafeghat, Melika; Shah, Syed M.; Shah, Jaffer; Shahbandi, Ataollah; Shahraki-Sanavi, Fariba; Shams-Beyranvand, Mehran; Shanawaz, Mohd; Sharafi, Kiomars; Sharifi‐Rad, Javad; Shetty, Jeevan K.; Varniab, Zahra Shokri; Shorofi, Seyed Afshin; Siabani, Soraya; Soltani-Zangbar, Mohammad Sadegh; Tabaeian, Seidamir Pasha; Tabatabaeizadeh, Seyed‐Amir; Tabish, Mohammad; Taheri, Majid; Abkenar, Yasaman Taheri; Soodejani, Moslem Taheri; Taherkhani, Amir; Tehrani-Banihashemi, Arash; Temsah, Mohamad-Hani; Tigabu, Bereket M.; Vakilian, Alireza; Vaziri, Siavash; Vo, Bay; Yazdanpanah, Fereshteh; Yiğit, Arzu; Yiğit, Vahit; Zahir, Mazyar; Zaman, Burhan Abdullah; Zamanian, Maryam; Zangiabadian, Moein; Zare, Iman; Zareshahrabadi, Zahra; Mokdad, Ali H.; Naghavi, Mohsen; Larijani, Bagher; Farzadfar, Farshad

doi:10.1016/j.eclinm.2023.102022

Cited by 5 publications

(3 citation statements)

References 32 publications

(39 reference statements)

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“…This is a retrospective analysis of patients' baseline kidney function and hemoglobin at their first visit to the HF clinic, and being a single-point estimation of eGFR might underestimate the burden of CRAS as it fluctuates due to many factors (e.g., Medication). In addition, given the high prevalence of DM in our region ( 16 ), the resultant hyperfiltration in the early stage of diabetic nephropathy might have masked the worsening in renal function. Furthermore, GFR was estimated using the MDRD equation, which is less accurate at higher GFR values ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

The prevalence of cardiorenal anemia syndrome among patients with heart failure and its association with all-cause hospitalizations: a retrospective single-center study from the Middle East

Manla,

Kholoki,

Bader

et al. 2023

Front. Cardiovasc. Med.

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Background and aimLittle is known about the burden of cardiorenal syndrome (CRS) and cardiorenal anemia syndrome (CRAS) in the Middle East Region. Furthermore, whether the occurrence rates of CRAS differ across heart failure (HF) phenotypes is not widely investigated. We aimed to examine the prevalence of CRS and CRAS in patients with HF, compare characteristics of patients with CRAS-HFrEF vs. CRAS-HFpEF, and investigate anemia association with 1-year all-cause hospitalizations.MethodsHF patients who visited a multidisciplinary HF clinic at a single center between 10-2015 and 06-2022 (n = 968) were retrospectively included. Differences in rates of CRAS prevalence, and patients’ characteristics of those with CRAS-HFrEF vs. CRAS-HFpEF were determined using appropriate testing methods. Generalized estimating equation (GEE) models were used to determine if anemia was associated with higher rates of hospitalization.ResultsCRS was prevalent in 34.4% of subjects, while 25.3% had CRAS. CRAS prevalence rates among patients with HFpEF vs. HFrEF were comparable (27.2% vs. 24.2%, p = 0.3). Compared to patients with HFrEF-CRAS, those with HFpEF-CRAS were more likely females (p < 0.001), had a higher burden of hypertension (p = 0.01), and lower hemoglobin (p = 0.02). In an adjusted GEE model, anemia was associated with an average increase of 1.8 admissions in CRS patients (p = 0.015).ConclusionIn patients with HF, 1 in 3 patients presented with CRS, and 1 in 4 patients had CRAS. The prevalence of CRAS was comparable among those HFpEF and HFrEF. Anemia was associated with an increased rate of 1-year all-cause hospitalization in CRS patients.

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Section: Discussionmentioning

confidence: 99%

The prevalence of cardiorenal anemia syndrome among patients with heart failure and its association with all-cause hospitalizations: a retrospective single-center study from the Middle East

Manla,

Kholoki,

Bader

et al. 2023

Front. Cardiovasc. Med.

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“…The Middle East region features a high burden of CVD, CAD, stroke, and its associated cardio-renal-metabolic risk factors, as well as a high burden of heart failure ( 11 – 17 ). Limited data are available on Lp(a) testing from the Middle East Gulf region.…”

Section: Introductionmentioning

confidence: 99%

Trends and findings of lipoprotein(a) testing and associated cardiovascular disease profiles: a large single-center study from the Middle East-Gulf region

Manla,

AbdelWareth,

Shantouf

et al. 2024

Front. Cardiovasc. Med.

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BackgroundLipoprotein(a) [Lp(a)] is a genetically determined risk factor for atherosclerotic cardiovascular disease (CVD). Limited data are available on Lp(a) testing from the Middle-East region. Therefore, we aim to evaluate the utilization and yield of Lp(a) testing over time and characterize CVD profiles of patients with abnormal Lp(a) tasting at a single-quaternary-care center in the United Arab Emirates.MethodsUnique Lp(a) tests conducted between 07/2017 and 10-2023 were included. Overtime trends in Lp(a) test utilization and abnormal Lp(a) [defined as Lp(a) > 125 nmol/L] test findings were described. CVD rates in patients with abnormal Lp(a) were compared to those with Lp(a) ≤ 125 nmol/L using appropriate methods.ResultsIn our center, 0.95% of the patients (n = 5,677) had their Lp(a) measured, with a median level of 32 [11–82] nmol/L. Lp(a) was abnormal in 15.9% of the tests. Over the years 2018–2022, there was a 109% increase in Lp(a) testing, with concomitant up-trends in findings of abnormal Lp(a) (11.8% to 16.4%, P = 0.02). Compared to patients with Lp(a) ≤ 125 nmol/I, those with abnormal Lp(a) had higher rates of any prevalent CVD (34% vs. 25.1%, P < 0.001), CAD (25.6% vs. 17.7%, P < 0.001), HF (6.5% vs. 3.8%, P < 0.001), and stroke (7.1% vs. 4.4%, P < 0.001).ConclusionAlmost one in six patients tested for Lp(a) had abnormally elevated Lp(a), and CVD was prevalent in one-third of the patients who tested abnormal for Lp(a). The study highlights the growing awareness of the relevance of Lp(a) for CVD risk stratification and prevention.

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“…The Middle East Region features a growing burden of heart failure with a concomitant high burden of cardio-renal-metabolic risk factors. 6 7) Limited data are available on patients with CRS and why they get hospitalized, particularly from the Middle East. In a previous analysis, we found that one-third (34.4%) of the patients visiting the HF clinic (n=968) had CRS (referring to type II or IV).…”

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Causes of Hospitalization in Patients With Cardiorenal Syndrome Across the Spectrum of Ejection Fraction

Manla,

Kholoki,

Attallah

et al. 2024

Int J Heart Fail

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The burden of metabolic risk factors in North Africa and the Middle East, 1990–2019: findings from the Global Burden of Disease Study

Cited by 5 publications

References 32 publications

The prevalence of cardiorenal anemia syndrome among patients with heart failure and its association with all-cause hospitalizations: a retrospective single-center study from the Middle East

The prevalence of cardiorenal anemia syndrome among patients with heart failure and its association with all-cause hospitalizations: a retrospective single-center study from the Middle East

Trends and findings of lipoprotein(a) testing and associated cardiovascular disease profiles: a large single-center study from the Middle East-Gulf region

Causes of Hospitalization in Patients With Cardiorenal Syndrome Across the Spectrum of Ejection Fraction

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