The Burden of Mental Illness Among Survivors of Critical Care—Risk Factors and Impact on Quality of Life

Teixeira, Cassiano; Rosa, Régis Goulart; Sganzerla, Daniel; Sanchez, Evelin Carneiro; Robinson, Caroline Cabral; Dietrich, Camila; Kochhann, Renata; Souza, Denise de; Rech, Gabriela Soares; Santos, Rosa da R. dos; Schneider, Daniel; Boldo, Rodrigo; Sharshar, Tarek; Bozza, Fernando A.; Falavigna, Maicon; Friedman, Gilberto

doi:10.1016/j.chest.2021.02.034

Cited by 33 publications

(35 citation statements)

References 18 publications

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“…They examined 3,151 patients who stayed in the ICU for more than 24 hours and revealed an 18% PTSD prevalence, which was significantly higher than our rate. However, their median APACHE score was 15 (11)(12)(13)(14)(15)(16)(17)(18)(19), which was comparable to that in our study population. A recent systematic review also suggested that illness severity was not associated with the development of PTSD [19]; thus, it is unlikely that mental illness severity at admission contributed to the difference in the prevalence of PTSD between our study and previous studies.…”

Section: Plos Onesupporting

confidence: 81%

“…A recent study [ 15 ] suggested that emotional memories may play a key role in PTSD development. Many studies [ 16 – 18 ] have attempted to clarify the risk factors for the development of PTSD after ICU stay. A recent systematic review and meta-analysis suggested that younger age, female patients, presence of delirium in the ICU, preexistence of a psychological disorder, administration of analgesics, and negative ICU experience were significant risk factors for the development of PTSD after ICU stay [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…A recent study [15] suggested that emotional memories may play a key role in PTSD development. Many studies [16][17][18] have attempted to clarify the risk factors for the development of…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of and risk factors for post-intensive care syndrome: Multicenter study of patients living at home after treatment in 12 Japanese intensive care units, SMAP-HoPe study

et al. 2021

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Few studies have examined the epidemiology of post-intensive care syndrome in Japan. This study investigated the mental health and quality of life of patients living at home in Japan after intensive care unit (ICU) discharge. Additionally, we examined whether unplanned admission to the ICU was associated with more severe post-traumatic stress disorder (PTSD), anxiety, and depressive symptoms. An ambidirectional cohort study was conducted at 12 ICUs in Japan. Patients who stayed in the ICU for > 3 nights and were living at home for 1 year afterward were included. One year after ICU discharge, we retrospectively screened patients and performed a mail survey on a monthly basis, including the Impact of Event Scale—Revised (IER-S), the Hospital Anxiety Depression Scale (HADS), and the EuroQOL—5 Dimension (EQ-5D-L) questionnaires. Patients’ characteristics, delirium and coma status, drugs used, and ICU and hospital length of stay were assessed from medical records. Descriptive statistics and multilevel linear regression modeling were used to examine our hypothesis. Among 7,030 discharged patients, 854 patients were surveyed by mail. Of these, 778 patients responded (response rate = 91.1%). The data from 754 patients were analyzed. The median IES-R score was 3 (interquartile range [IQR] = 1‒9), and the prevalence of suspected PTSD was 6.0%. The median HADS anxiety score was 4.00 (IQR = 1.17‒6.00), and the prevalence of anxiety was 16.6%. The median HADS depression score was 5 (IQR = 2‒8), and the prevalence of depression was 28.1%. EQ-5D-L scores were lower in our participants than in the sex- and age-matched Japanese population. Unplanned admission was an independent risk factor for more severe PTSD, anxiety, and depressive symptoms. Approximately one-third of patients in the general ICU population experienced mental health issues one year after ICU discharge. Unplanned admission was an independent predictor for more severe PTSD symptoms.

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Section: Plos Onesupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

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Prevalence of and risk factors for post-intensive care syndrome: Multicenter study of patients living at home after treatment in 12 Japanese intensive care units, SMAP-HoPe study

et al. 2021

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“…As in the study reported by Milton et al, 10 the authors assessed a number of risk factors for long-term emotional distress; they had longterm outcome data on 579 patients. Unlike Milton et al, 10 Teixera et al 11 found that prior psychiatric morbidity (namely depression) and early post-ICU distress (especially depression symptoms) independently predicted 6-month psychiatric morbidity, which included anxiety and depression symptoms, although only post-ICU depression independently predicted posttraumatic stress disorder symptoms. Teixeira et al 11 also noted that 6-month emotional distress was associated strongly with decreased physical functioning and dependence on others, although these physical outcomes were assessed simultaneously at 6-month follow up and may actually represent complications of emotional distress, as opposed to risk factors.…”

mentioning

confidence: 79%

“…With the use of the four independent predictors as an instrument for 3-month emotional distress, the area under the receiver operating curve was 76%. 10 In this issue of CHEST, Teixeira et al 11 present data from another large multicenter prospective cohort study of critical illness survivors in Brazil and focused on 6month mental health outcomes. As in the study reported by Milton et al, 10 the authors assessed a number of risk factors for long-term emotional distress; they had longterm outcome data on 579 patients.…”

mentioning

confidence: 99%