The burden of illness in initiating intermittent catheterization: an analysis of German health care claims data

Angermund, A.; Inglese, Gary; Goldstine, Jimena; Iserloh, Laura; Libutzki, Berit

doi:10.1186/s12894-021-00814-7

Cited by 8 publications

(2 citation statements)

References 19 publications

(9 reference statements)

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“…Postcatheterization, PVP-coating was observed to remain behind on the urethral model, suggesting that hydrophilic PVP-coated catheters have the potential to leave coating residue behind in the urethra on withdrawal from a patient’s bladder. Importantly, the urethral model was catheterized once, however, in vivo intermittent catheterization is performed multiple times a day. , This raises the question of whether delamination of hydrophilic PVP-coated catheters occurs in vivo and what clinical consequences accumulation of these residues might have. The clinical relevance and long-term significance of hydrophilic PVP-coated catheters’ adhesive characteristics, coating delamination and coating residues remain unknown .…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, the urethral model was catheterized once, however, in vivo intermittent catheterization is performed multiple times a day. 29,30 This raises the question of whether delamination of hydrophilic PVP-coated catheters occurs in vivo and what clinical consequences accumulation of these residues might have. The clinical relevance and long-term significance of hydrophilic PVP-coated catheters' adhesive characteristics, coating delamination and coating residues remain unknown.…”

Section: Discussionmentioning

confidence: 99%

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Comparing an Integrated Amphiphilic Surfactant to Traditional Hydrophilic Coatings for the Reduction of Catheter-Associated Urethral Microtrauma

Burns,

Pollard,

Ali

et al. 2024

ACS Omega

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Hydrophilic-coated intermittent catheters have improved the experience of intermittent urinary catheterization for patients compared to conventional gel-lubricated uncoated catheters. However, the incorporation of polyvinylpyrrolidone (PVP) within hydrophilic coatings can lead to significant issues with coating dry-out. Consequently, increased force on catheter withdrawal may cause complications, including urethral microtrauma and pain. Standard methods of evaluating catheter lubricity lack physiological relevance and an understanding of the surface interaction with the urethra. The tribological performance and urethral interaction of commercially available hydrophilic PVP-coated catheters and a coating-free integrated amphiphilic surfactant (IAS) catheter were evaluated by using a biomimetic urethral model designed from a modified coefficient of friction (CoF) assay. T24 human urothelial cells were cultured on customized silicone sheets as an alternate countersurface for CoF testing. Hydrophilic PVP-coated and coating-free IAS catheters were hydrated and the CoF obtained immediately following hydration, or after 2 min, mimicking in vivo indwell time for urine drainage. The model was observed for urethral epithelial cell damage postcatheterization. The majority of hydrophilic PVP-coated catheters caused significantly greater removal of cells from the monolayer after 2 min indwell time, compared to the IAS catheter. Hydrophilic PVP-coated catheters were shown to cause more cell damage than the coating-free IAS catheter. A biomimetic urethral model provides a more physiologically relevant model for understanding the factors that govern the frictional interface between a catheter surface and urethral tissue. From these findings, the use of coating-free IAS catheters instead of hydrophilic PVP-coated catheters may help reduce urethral microtrauma experienced during catheter withdrawal from the bladder, which may lead to a lower risk of infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparing an Integrated Amphiphilic Surfactant to Traditional Hydrophilic Coatings for the Reduction of Catheter-Associated Urethral Microtrauma

Burns,

Pollard,

Ali

et al. 2024

ACS Omega

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The cost of lifelong LUTS—A systematic literature review

Holm‐Larsen,

Van den Ende,

Wendelboe

et al. 2024

Neurourology and Urodynamics

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BackgroundLower urinary tract symptoms (LUTS) are highly prevalent and very bothersome. To support the best possible allocation of health care resources and to avoid unnecessary expenditures, it is important to understand and quantify the wide‐ranging health care costs affecting people suffering from LUTS. We aimed at creating a foundation for exploring the cost of LUTS.MethodIn this systematic literature review, we explored the costs of illness of the LUTS umbrella. We used the online literature review tool Silvi.ai for transparent decision‐making and literature management.ResultsA total of 1821 original articles were screened. Forty had explored the cost of illness of a LUTS disease since 2013. The studies were conducted in 18 countries. A number of different study designs were applied, including both retrospective and prospective studies. In total, seven LUTS indications were explored. None of them focused on lifelong LUTS. None of them were conducted in infants or children. Eighty‐two percent were conducted in adults and 18% in frail elderly. Most cost of illness studies focused on the cost of hospitalization and use of medicine.ConclusionWe have created the groundwork for understanding the cost of LUTS illness. To fully understand the cost of illness of lifelong LUTS, the main gap in research is to investigate the cost of LUTS in infants and children.

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New micro-hole zone catheter reduces residual urine and mucosal microtrauma in a lower urinary tract model

Schrøder,

Tentor,

Miclăuş

et al. 2024

Sci Rep

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Urinary tract infections (UTIs) are the main complication associated with clean intermittent catheterization (CIC) and are facilitated by post-void residual urine and trauma to the mucosa during voiding. The risk of UTI may be diminished by reducing the residual volumes and preventing microtrauma caused by mucosal suction through the eyelets of conventional eyelet catheters (CEC). A new micro-hole zone catheter (MHZC) was developed and tested in an ex vivo porcine lower urinary tract model and in vivo, in pigs, against a CEC. It was shown that, irrespective of the micro-hole diameter, the new catheter ensured increased flowrates and significantly lower residual volumes at the first flow-stop. Furthermore, with a micro-hole diameter of 0.4 mm, mucosal suction was virtually eliminated, regardless of the insertion depth or simulated intra-abdominal pressure mimicking sitting or standing humans. Pressure profile experiments and endoscopy studies indicated that the bladder gradually folds against the drainage tip of the new catheter, without blocking the flow, and, unlike with the CEC, sharp pressure variations and flow-stops did not occur during voiding. The MHZC outperformed the CEC in all tested scenarios and decreased residual volumes, thus potentially decreasing the risk of UTIs.

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The burden of illness in initiating intermittent catheterization: an analysis of German health care claims data

Cited by 8 publications

References 19 publications

Comparing an Integrated Amphiphilic Surfactant to Traditional Hydrophilic Coatings for the Reduction of Catheter-Associated Urethral Microtrauma

Comparing an Integrated Amphiphilic Surfactant to Traditional Hydrophilic Coatings for the Reduction of Catheter-Associated Urethral Microtrauma

The cost of lifelong LUTS—A systematic literature review

New micro-hole zone catheter reduces residual urine and mucosal microtrauma in a lower urinary tract model

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