The burden of <i>Helicobacter pylori</i> infection in England and Wales

Vyse, Andrew; Hesketh, Louise; Andrews, Nicholas; Marshall, Barry J.; Thomas, H. I. J.; Morgan‐Capner, P.; Miller, Elizbeth

doi:10.1017/s0950268802006970

Cited by 50 publications

(42 citation statements)

References 27 publications

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“…5 million people in England and Wales (Vyse et al, 2002). The organism induces a chronic gastritis and, although associated clinical disease presentations develop in less than 20 % of individuals, is recognized as a cause of peptic ulcer disease and associated with lymphoproliferative disorders as well as the development of gastric carcinoma (Suerbaum & Michetti, 2002).…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori antibiotic-resistance patterns and risk factors in adult dyspeptic patients from ethnically diverse populations in central and south London during 2000

Elviss

Owen

Breathnach

et al. 2005

Journal of Medical Microbiology

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Surveillance of Helicobacter pylori antibiotic susceptibility from patients in London, the largest metropolitan area in the UK, is limited, despite resistance being a key factor in treatment failure. A two-centre survey was performed over 12 months (1999)(2000) to determine antibiotic-resistance rates of isolates from dyspeptic patients attending endoscopy clinics serving two ethnically diverse central and south London communities. The in vitro antibiotic susceptibilities were determined from disc diffusion and epsilometer (E) tests on 101 H. pylori isolates. Overall resistance rates were 59 % for metronidazole and 11 % for clarithromycin, with 8 % resistance to both antibiotics. Corresponding primary resistance rates were 50 % and 7 %, respectively. High-level-resistance was a feature of 82 % of the metronidazole (MIC > 256 mg l À1 ) -resistant and 55 % of the clarithromycin (MIC > 32 mg l À1 ) -resistant strains. All isolates were susceptible to amoxycillin and tetracycline. No associations between resistance and either the gender or the age of the patients were detected. The main risk for resistance to metronidazole was non-UK birth as comparative rates were 68 % for non-UK vs. 40 % for UK-born individuals. Resistant isolates were genotypically diverse with respect to cagA/vacA type. Four 23S rDNA nucleotide polymorphisms were associated with clarithromycin resistance, mostly (9/11) at A2143G. In conclusion, the high overall metronidazole-resistance rate of 59 % for H. pylori from inner London was twice the rate found in other UK-based studies and was attributed to the higher risk of resistant strains infecting individuals born outside the UK. The need for continued resistance surveillance is indicated to monitor the effects of the 'test and treat' strategy for H. pylori eradication, particularly of isolates from at-risk individuals

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Section: Introductionmentioning

confidence: 99%

Helicobacter pylori antibiotic-resistance patterns and risk factors in adult dyspeptic patients from ethnically diverse populations in central and south London during 2000

Elviss

Owen

Breathnach

et al. 2005

Journal of Medical Microbiology

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“…In temperate climates, chickenpox is a common childhood illness and seropositivity ranges from 53 to 100% in 5 year olds. [5][6][7] However, the VZV infection seroprevalence patterns in tropical countries are markedly different, with chickenpox mainly affecting young adults. [8][9][10] carried out in children aged between 12 and 18 months in some developed countries.…”

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confidence: 99%

Seroprevalence of varicella zoster virus infections in Colombo District, Sri Lanka

Liyanage¹,

Fernando²,

Malavige³

et al. 2007

Indian J Med Sci

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AIMS: For future VZV vaccination strategies, we set to determine the age-specific seroprevalence rate of VZV infections in Colombo, Sri MATERIALS AND METHODS: The study was carried out from 1999 to 2000. Multi stage cluster sampling technique was used to collect 913 blood samples, which were tested for the presence of VZV-specific IgG antibodies. RESULTS: VZV seroprevalence rates were markedly lower in all age groups when compared to temperate climates. The seroprevalence rates increased with age in both the rural and urban populations. Of those aged 60 years, only 50% in the rural population and 78.9% in the urban population were immune to VZV. Seroprevalence rates of VZV infections were significantly different between the urban and rural populations (P<0.001), with VZV specific IgG antibodies detected in 47.5% in the urban population and 27.9% in the rural population. It was found that 56.2% (131) of females of childbearing age were nonimmune to VZV. CONCLUSIONS: These findings highlight the need for a VZV vaccination program, which is likely to have a huge impact on the incidence of chickenpox and its associated morbidity and mortality.

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“…Although not always the cause of clinically manifest disease, H. pylori infection is strongly associated with peptic ulceration, as well as with increased risk for the development of mucosa-associated lymphoid tissue lymphoma and gastric cancer (10,11,13). Gastric infections with H. pylori have a worldwide distribution, with current prevalence rates about 35% in England and Wales (32) and more than 75% in many developing countries (26). No single pathogenicity factor has yet been proved to be uniquely associated with the ability of H. pylori to cause gastroduodenal ulcer disease or cancer (6,11).…”

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confidence: 99%

Identification ofcagATyrosine Phosphorylation DNA Motifs inHelicobacter pyloriIsolates from Peptic Ulcer Patients by Novel PCR-Restriction Fragment Length Polymorphism and Real-Time Fluorescence PCR Assays

et al. 2003

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Cag pathogenicity island-containing Helicobacter pylori (type I) induces signal transduction pathways resulting in tyrosine phosphorylation of proteins adjacent to the site of bacterial adhesion on host gastric epithelial cells. Conventional block PCR-restriction fragment length polymorphism (RFLP) and real-time LightCycler (LC) PCR hybridization assays, validated by direct sequencing, were designed to test for the presence of three nucleotide sequences corresponding to tyrosine phosphorylation motifs (TPMs) A, B, and C in 84 isolates of H. pylori type I from patients in England. Overall, the PCR assays demonstrated that one or more TPMs were present in 62 strains (75%). Motif A was common (71% of strains), whereas motifs B and C were rarer (8% of strains). Strains lacking a TPM were typically vacuolating cytotoxin genotype vacA m2. Motif A was widely distributed in relation to disease severity and was more commonly (but not significantly [P ‫؍‬ 0.071]) associated with gastric ulcer than with duodenal ulcer (86 versus 56%). The LC hybridization assay provided a rapid means of detecting all three motifs, but RFLP analysis was more specific for TPM-A. TPMs provide novel additional strain markers for defining cagA variation, including identification of RFLP types within TPM-A. The presence of a particular TPM was not of direct diagnostic value, either singly or in combination, but the higher proportion of TPM-A strains in gastric ulcer patients merits further investigation.

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The burden of Helicobacter pylori infection in England and Wales

Cited by 50 publications

References 27 publications

Helicobacter pylori antibiotic-resistance patterns and risk factors in adult dyspeptic patients from ethnically diverse populations in central and south London during 2000

Helicobacter pylori antibiotic-resistance patterns and risk factors in adult dyspeptic patients from ethnically diverse populations in central and south London during 2000

Seroprevalence of varicella zoster virus infections in Colombo District, Sri Lanka

Identification ofcagATyrosine Phosphorylation DNA Motifs inHelicobacter pyloriIsolates from Peptic Ulcer Patients by Novel PCR-Restriction Fragment Length Polymorphism and Real-Time Fluorescence PCR Assays

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