“…Lower levels of white matter abnormalities (Mannikko et al, 2015), moderate and high adherence is associated with reduced risk of cognitive decline (Shakersain et al, 2018a) Development of obesity, T2DM, dyslipidemia, hypertension and coronary heart disease (Martínez Steele et al, 2016;Rauber et al, 2019;Zhao et al, 2018;Rico-Campà et al, 2019), increased risk of dementia (Martínez Leo and Segura Campos, 2020;Francis and Stevenson, 2013;Jacka et al, 2015;Kanoski and Davidson, 2011;Srour and Touvier, 2020) and impaired blood brain barrier integrity and hippocampal damage (Hsu and Kanoski, 2014) Mechanism of action Improvements in gut microbiota (Medawar et al, 2019), anti-inflammatory (Bonaccio et al, 2013;McEvoy et al, 2017;Gkotzamanis and Panagiotakos, 2020), antioxidant (Berti et al, 2018), blood lipid lowering effects (Soltani et al, 2020) Chronic Inflammation (Monteiro et al, 2019b), increase in adipose tissue (Steele et al, 2021), hyperinsulinemia…”