The burden of digestive disease across Europe: Facts and policies

O'Morain, Neil; O’Moráin, Colm

doi:10.1016/j.dld.2018.10.001

Cited by 16 publications

(11 citation statements)

References 9 publications

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“…Cholangiocarcinoma (CCA), a common cancer with highly aggressive and malignant symptoms, accounts for approximately 2–3% of digestive tract tumors, and the incidence and mortality of CCA have been increasing worldwide 1 . Although considerable progress has been made in developing many pharmacological interventions for CCA, the mortality rate for patients with CCA still increased by 39% 2–4 . Therefore, it is essential to elucidate the physiological and molecular mechanisms of CCA in order to develop novel and effective therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

LncRNA NEAT1 promotes cell proliferation, migration, and invasion via the miR‐186‐5p/PTP4A1 axis in cholangiocarcinoma

Jiang

et al. 2021

The Kaohsiung J of Med Scie

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Cholangiocarcinoma (CCA) is a highly aggressive and malignant tumor. In this study, the effect and molecular mechanism of nuclear enriched abundant transcript 1 (NEAT1) in CCA were elucidated. The expressions of NEAT1, microRNA‐186‐5p (miR‐186‐5p), and PTP4A1 were measured by quantitative real‐time PCR. The protein levels were measured by Western blotting. Kaplan–Meier analysis was performed to create survival curves. The interactions between NEAT1, miR‐186‐5p, and PTP4A1 were assessed through the dual luciferase reporter assay. Additionally, the cell proliferation, apoptosis, migration, and invasion were measured by colony formation, flow cytometry, the Transwell assay, and the wound healing assay, respectively. NEAT1 and PTP4A1 were significantly upregulated in CCA tissues and cells, but miR‐186‐5p was downregulated. NEAT1 expression was negatively correlated with the survival of CCA patients and has remarkable correlation with serum CA199 levels and lymph node metastasis. Besides, NEAT1 could act as a molecular sponge for miR‐186‐5p to upregulate PTP4A1 expression. More importantly, the knockdown of NEAT1 or overexpression of miR‐186‐5p inhibited the proliferation, migration and invasion of CCA cells, and the inhibition of miR‐186‐5p reversed the effects of the knockdown of NEAT1. In addition, NEAT1 could also activate the PI3K/AKT signaling pathway and regulate the epithelial‐mesenchymal transition (EMT) through the miR‐186‐5p/PTP4A1 axis. In conclusion, NEAT1 was involved in cell proliferation, migration and invasion in CCA, and the NEAT1/miR‐186‐5p/PTP4A1/PI3K/AKT axis indicated novel regulatory mechanisms and therapeutics for the treatment of CCA.

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Section: Introductionmentioning

confidence: 99%

LncRNA NEAT1 promotes cell proliferation, migration, and invasion via the miR‐186‐5p/PTP4A1 axis in cholangiocarcinoma

Jiang

et al. 2021

The Kaohsiung J of Med Scie

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“…It is estimated that in 2015, annual health care costs totalled $ 135.9 billion in the United States [1]. In Europe, recent data suggest that there is a growing incidence of functional and malignant gastrointestinal disease across the continent, leading to an increased demand for outpatient visits, hospitalizations, diagnostic techniques, and invasive procedures [2].…”

Section: Introductionmentioning

confidence: 99%

Digestive findings that do not require endoscopic surveillance – Reducing the burden of care: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement

et al. 2020

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Summary of StatementsWith the aim of reducing the overall burden of care, ESGE recommends against surveillance of a series of conditions. Namely: ESGE recommends against surveillance of individuals with the following: an inlet esophageal patch; Los Angeles (LA) grade A or B erosive esophagitis; or < 1 cm columnar-lined esophagus. ESGE recommends against surveillance of those with intestinal metaplasia limited to the antrum unless additional risk factors are present, such as persistent Helicobacter pylori infection, incomplete metaplasia, or a family history of gastric cancer; or for fundic gland polyps in the absence of suspicious endoscopic features or hereditary syndromes. ESGE recommends against surveillance of gastrointestinal leiomyomas, lipomas, and antral pancreatic rests, provided that these lesions have typical ultrasonographic features. ESGE recommends against routine endoscopic surveillance in duodenal peptic ulcer, unless symptoms persist despite adequate therapy. ESGE suggests against surveillance of confirmed pancreatic serous cystic neoplasms. ESGE recommends against endoscopic surveillance for patients with hyperplastic polyps in the rectosigmoid, with 1 – 4 adenomas < 10 mm with low-grade dysplasia, or with a serrated polyp < 10 mm without dysplasia. ESGE recommends against surveillance of gastrointestinal conditions in individuals over 80 years old who have less than 10 years of life expectancy and poor general health status.

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“…Gastrointestinal, liver, and pancreatic diseases are notable for requiring a substantial use of healthcare resources on a regular basis worldwide 3–5 . The impact of the COVID‐19 pandemic on endoscopy activity has recently been evaluated in Italy, where most units limited their activity to urgent cases 6 .…”

Section: Introductionmentioning

confidence: 99%

Massive impact of coronavirus disease 2019 pandemic on gastroenterology and hepatology departments and doctors in Spain

Crespo

Fernández-Carrillo

Iruzubieta

et al. 2020

J of Gastro and Hepatol

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Background and Aim Significant human and material resources have been diverted to coronavirus disease 2019 (COVID‐19). Healthcare workers are at high risk of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. We assess the impact of the COVID‐19 pandemic on gastroenterology and hepatology departments and specialists in Spain. Methods This study involves a nationwide survey addressing the impact of COVID‐19 on resources, procedures, and physicians of gastroenterology and hepatology departments in 81 hospitals representative of the Spanish National Health Service. Results Overall, 41.8% of hospital beds and 40.7% of gastroenterology and hepatology beds were allocated to COVID‐19 patient care, as well as 24.8% of gastroenterologists and 58.3% of residents. Outpatient visits, abdominal ultrasounds, and endoscopies were reduced by 81.8–91.9%. Nine large university hospitals had 75% and 89% reductions in therapeutic endoscopies and hepatocellular carcinoma surgery, respectively, with cancelation of elective liver transplant and transjugular intrahepatic portosystemic shunt. Prevalence of infected physicians was 10.6% and was dependent on regional population incidence (r = 0.74, P = 0.001), with 11% hospitalized and one physician dying. Up to 63.4% of physicians may have been infected before or shortly after Spain entered lockdown, 57% of them having recently performed endoscopies. Adequate protection was acknowledged in > 80% hospitals, but only 2.9% performed regular SARS‐CoV‐2 testing. Conclusions The impact of the COVID‐19 pandemic on healthcare delivery has been massive. A wave of gastroenterology‐related complications is expected because of resource diversion. Gastroenterologists have a high prevalence of infection, although they may have been infected during a first phase of lower awareness and protection. Regular SARS‐CoV‐2 screening, adequate protection, and quick reorganization of healthcare resources are still needed.

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The burden of digestive disease across Europe: Facts and policies

Cited by 16 publications

References 9 publications

LncRNA NEAT1 promotes cell proliferation, migration, and invasion via the miR‐186‐5p/PTP4A1 axis in cholangiocarcinoma

LncRNA NEAT1 promotes cell proliferation, migration, and invasion via the miR‐186‐5p/PTP4A1 axis in cholangiocarcinoma

Digestive findings that do not require endoscopic surveillance – Reducing the burden of care: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement

Massive impact of coronavirus disease 2019 pandemic on gastroenterology and hepatology departments and doctors in Spain

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