The Burden of Childhood Asthma and Late Preterm and Early Term Births

Harju, Maijakaisa; Keski‐Nisula, Leea; Georgiadis, Leena; Räisänen, Sari; Gissler, Mika; Heinonen, Seppo

doi:10.1016/j.jpeds.2013.09.057

Cited by 84 publications

(72 citation statements)

References 19 publications

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“…Being born prematurely and neonatal chronic lung disease have been consistently demonstrated to lead to decrements in lung function and increased respiratory symptoms (Vergheggen et al 2016) and the findings of this study confirm earlier studies (Harju et al 2014). Age of home <5 years was a significant predictor, however the results must be treated with caution due to the small effect size, nevertheless it is possible that there are pollutants associated with newer homes which may contribute to poorer lung function (Jaakola et al 2004;Mendell, 2007).…”

Section: Discussionsupporting

confidence: 91%

Investigating the relationship between environmental factors and respiratory health outcomes in school children using the forced oscillation technique

Boeyen

Callan

Blake

et al. 2017

International Journal of Hygiene and Environmental Health

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The environmental factors which may affect children’s respiratory health are complex, and the influence and significance of factors such as traffic, industry and presence of vegetation is still being determined. We undertook a cross-sectional study of 360 school children aged 5–12 years who lived on the outskirts of a heavy industrial area in Western Australia to investigate the effect of a range of environmental factors on respiratory health using the forced oscillation technique (FOT), a non-invasive method that allows for the assessment of the resistive and reactive properties of the respiratory system. Based on home address, proximity calculations were used to estimate children’s exposure to air pollution from traffic and industry and to characterise surrounding green space. Indoor factors were determined using a housing questionnaire. Of the outdoor measures, the length of major roads within a 50 m buffer was associated with increased airway resistance (Rrs8). There were no associations between distance to industry and FOT measures. For the indoor environment the presence of wood heating and gas heating in the first year of life was associated with better lung function. The significance of both indoor and outdoor sources of air pollution and effect modifiers such as green space and heating require further investigation

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Section: Discussionsupporting

confidence: 91%

Investigating the relationship between environmental factors and respiratory health outcomes in school children using the forced oscillation technique

Boeyen

Callan

Blake

et al. 2017

International Journal of Hygiene and Environmental Health

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“…Harju et al 25 also assessed the effect of gestational age at birth and the risk of having asthma in childhood and showed that early OR (95% CI) 1.2 (0.9-1.8) P 5 .230 P 5 .070 Adjusted* OR (95% CI) 0.99 (0.89-1.1) P 5 .820 *Adjusted for gestational age group at birth. J ALLERGY CLIN IMMUNOL VOLUME nnn, NUMBER nn term and late preterm deliveries contribute most to the additional cases of asthma compared with those born at 39 to 40 weeks' gestation, although they only assessed the risk of medically diagnosed asthma by relying on registry-collected data and were unable to comment on symptoms or severity.…”

Section: Discussionmentioning

confidence: 99%

Early-term birth is a risk factor for wheezing in childhood: A cross-sectional population study

Edwards

Kotecha

Lowe

et al. 2015

Journal of Allergy and Clinical Immunology

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“…Even late preterm infants have increased respiratory symptoms and greater likelihood of being given a diagnosis of asthma,39 although the exact cause for the symptoms is unclear (see below).…”

Section: Preterm Birth and Childhood Lung Healthmentioning

confidence: 99%

Lung consequences in adults born prematurely

Bolton

Bush

Hurst

et al. 2015

Thorax

120

110

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Although survival has improved significantly in recent years, prematurity remains a major cause of infant and childhood mortality and morbidity. Preterm births (<37 weeks of gestation) account for 8% of live births representing >50 000 live births each year in the UK. Preterm birth, irrespective of whether babies require neonatal intensive care, is associated with increased respiratory symptoms, partially reversible airflow obstruction and abnormal thoracic imaging in childhood and in young adulthood compared with those born at term. Having failed to reach their optimal peak lung function in early adulthood, there are as yet unsubstantiated concerns of accelerated lung function decline especially if exposed to noxious substances leading to chronic respiratory illness; even if the rate of decline in lung function is normal, the threshold for respiratory symptoms will be crossed early. Few adult respiratory physicians enquire about the neonatal period in their clinical practice. The management of these subjects in adulthood is largely evidence free. They are often labelled as asthmatic although the underlying mechanisms are likely to be very different. Smoking cessation, maintaining physical fitness, annual influenza immunisation and a general healthy lifestyle should be endorsed irrespective of any symptoms. There are a number of clinical and research priorities to maximise the quality of life and lung health in the longer term not least understanding the underlying mechanisms and optimising treatment, rather than extrapolating from other airway diseases.

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The Burden of Childhood Asthma and Late Preterm and Early Term Births

Cited by 84 publications

References 19 publications

Investigating the relationship between environmental factors and respiratory health outcomes in school children using the forced oscillation technique

Investigating the relationship between environmental factors and respiratory health outcomes in school children using the forced oscillation technique

Early-term birth is a risk factor for wheezing in childhood: A cross-sectional population study

Lung consequences in adults born prematurely

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