The burden of cardiac arrhythmias in sarcoidosis: a population-based inpatient analysis

Abstract

Background: Cardiac involvement in the sarcoidosis is known to ensue with diverse clinical forms and its investigation is challenging at times. This article features the under-perceived burden, patterns, and outcomes of different arrhythmias, which may have a prognostic significance in patients with sarcoidosis. Methods: We queried the National Inpatient Sample (NIS) for 2010-2014 to recognize sarcoidosis, arrhythmia, and comorbidities affecting hospitalizations. The nationwide estimates were attained using discharge records. We assessed incidence and trends in sarcoidosis-related arrhythmia and consequential inpatient mortality, hospital length of stay (LOS), hospitalization charges and predictors of mortality with multivariate analysis. Results: We identified 369,285 sarcoidosis-related hospitalizations. Of these, nearly one-fifth suffered from arrhythmias (n=73,424). The sarcoidosis patients developing arrhythmias were older (61.9 vs. 56.0 years) compared to those without. Males had the higher incidence of arrhythmias compared to females. Atrial fibrillation (Afib) (10.97%) was the most common subtype, followed by ventricular tachycardia (1.97%). There was a rising trend in arrhythmia-related hospital admissions and mortality among sarcoidosis, with Afib incidence displaying the highest increase. Traditional cardiac comorbidities were higher in the sarcoid-arrhythmia group. The arrhythmia group had significantly higher mortality (3.7% vs. 1.5%), mean hospital LOS (6.4 vs. 5.2 days) and hospital charges ($64,118 vs. $41,565) compared to non-arrhythmia group (P<0.001). Incident arrhythmia significantly increased the mortality odds in sarcoidosis (adjusted odds ratio, 2.06). Conclusions: The growing trend, deteriorating outcomes and higher mortality associated with sarcoidrelated arrhythmias highlight the importance of timely diagnosis and aggressive management in this population.

Burden of arrythmias in transgender patients hospitalized for gender‐affirming surgeries

“…The most common arrhythmia in our population, atrial fibrillation (2.87%) is lower than the reported 4% incidence in the general surgery population 11 . The finding that atrial fibrillation as the commonest arrythmia in our cohort, compares well with prior analyses using the NIS for various disease states 5,8,9,13 . It has been hypothesized that low testosterone in transgender females may increase the risk for atrial and ventricular arrhythmia 14 .…”

“…This study includes hospitalizations from the NIS which has been described elsewhere 5,6 . We included hospitalizations from January 2012 to September 2015 and identified hospitalizations using International Classifications of Diseases, Ninth Revision, Clinical Modification (ICD‐9‐CM) diagnostic codes.…”

Sickle cell disease‐associated arrhythmias and in‐hospital outcomes: Insights from the National Inpatient Sample

“…International Classification of Diseases, Ninth Revision, Clinical Modification (ICD‐9‐CM) codes were used as reported earlier to identify hospitalized SCD patients as primary diagnosis (282.41, 282.42, 282.6, 282.60‐282.64, 282.68, and 282.69) and arrhythmias as secondary diagnosis (ICD‐9‐CM codes for atrial fibrillation [AFib] 427.31, atrial flutter [AF] 427.32, supraventricular tachycardia [SVT] 427.0, ventricular fibrillation [VFib] 427.41, ventricular tachycardia [VT] 427.1, atrioventricular [AV] block 426.0, 426.10, 426.11, 426.12, 426.13 and unspecified arrhythmias 427.2, 427.9, 427.89, 785.0) 3,11–14 …”

Rising Trends in Medication Non-compliance and Associated Worsening Cardiovascular and Cerebrovascular Outcomes Among Hospitalized Adults Across the United States

“…A review summarizing the impact of nonadherence on health care cost in several chronic diseases such as diabetes, CVD, and chronic obstructive pulmonary disease concluded that increasing the medication adherence significantly reduces the overall health care cost [16]. Our prior analyses have revealed close etiopathological and prognostic link of cardiovascular disorders and outcomes with endocrine, respiratory, or psychiatric disorders which also suggests that medications targeted for one organ system can help prevent overall complications, improve quality of life, and improve long-term prognosis [13,[17][18][19][20][21].…”