The burden of aortic aneurysm in China from 1990 to 2019: findings from the Global Burden of Disease Study 2019

Abstract

Background Aortic aneurysm (AA) is a global public health concern. However, little is known about the disease burden of AA in China. Methods Following the general analytic strategy used in the Global Burden of Disease Study (GBD) 2019, we analyzed the mortality and years of life lost (YLLs) due to AA, stratified by sex, age, and province-level region in China from 1990 to 2019. The temporal trend of AA burden in China was analyzed and the main attributable risk factors for AA in China were also explored. Results In China, the total AA deaths were 17,038 (95% UI: 14,392-19,980) in 2019, an increase of 136.1% compared with that in 1990, with an age-standardized death rate (ASDR) of 0.93 (95% UI: 0.79-1.08) per 100,000 person-years in 2019, a decrease of 6.8%. Meanwhile AA caused 378,578 (95% UI: 315,980-450,479) YLLs in 2019, an increase of 102.6% compared with that in 1990, with a crude YLL rate of 26.6 (95% UI: 22.2-31.7) per 100,000 person-years, an increase of 68.6%. The AA mortality and YLLs were higher in males than in females. AA caused most YLLs in the 65- to 75-year-old age group. The AA mortality and YLLs varied significantly among provinces in China, and the change in ASDR showed a negative correlation with the sociodemographic index of different provinces, namely, more decline of ASDR in developed provinces. High systolic blood pressure was shown to be the most significant attributable risk factor for AA burden in both males and females, and smoking was another major attributable risk factor, especially in males. Conclusions The disease burden of AA increased significantly from 1990 to 2019 in China, with higher mortality and YLLs in males, senior populations, and among residents of most western provinces in China. High systolic blood pressure and smoking were two major attributable risk factors for AA mortality in China.

Mortality trend of heart diseases in China, 2013–2020

“…Implementation of automated external defibrillator outside hospital settings in China is minimal and must be strengthened. Consistent with a previous study [8] , we found increasing ASMR of AA from 2013 to 2020, which in turn may be attributed to increased metabolic risk factors, such as high blood pressure and atherosclerosis [24,25] , and improved diagnostic standards and screening technology [26] . In sharp contrast to the Global downward trend [27,28] , we found a slight increase in the ASMR of NRVHDs in recent years, suggesting insufficient programs for diseases with low but increasing ASMR.…”

“…The increase in the ASMR of heart diseases during the study period in Xinjiang is perplexing and may involve increased exposure to risk factors and lifestyle issues. Higher ASMR is associated with lower sociodemographic index [25] . We also noticed decreased standard deviation of ASMR of heart diseases in and number of provinces during the study period, indicating narrowing regional disparity.…”

Objective assessment of the association between telomere length, a biomarker of aging, and health screening indicators: A cross-sectional study

“…[2] According to the Global Burden of Disease 2019 findings, aging populations in industrialized countries are living longer but in poorer health, and healthcare systems are heavily burdened. [3] Presently, the global population is witnessing a shift toward an unprecedented era of population aging. Recent data reveals that approximately 9% of the world’s populace has surpassed the age of 65, and this proportion is projected to escalate to 16% by 2050.…”