The Buccale Puzzle: The Symbiotic Nature of Endogenous Infections of the Oral Cavity

Ruby, John D.; Barbeau, Jean

doi:10.1155/2002/492656

Cited by 45 publications

(50 citation statements)

References 53 publications

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“…Although biofilms are required for health of the oral cavity, biofilms are also known to contain pathogens (Ruby and Barbeau, 2002). Since inflammatory disease of the peridontium is caused by the microflora that are present in the gingival crevice, the mystery is not that disease can be brought on by these pathogenic bacteria, but what changes in their status to bring on the disease.…”

Section: The Oral Microbiota and Diseasementioning

confidence: 99%

“…These biofilms are typically comprised mainly of Gram-positive facultative anaerobes ( Streptococcus anginosus and A. naeslundii ), but in the absence of proper hygiene, the percentage of Gram-negative species (e.g., Porphyromonas spp., Campylobacter spp., T. forsythia , Treponema denticola , and A. actinomycetemcomitans ) in the biofilms increases, contributing to periodontal inflammation (Ruby and Barbeau, 2002). …”

Section: The Oral Microbiota and Diseasementioning

confidence: 99%

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The Oral Microbiota: Living with a Permanent Guest

Avila

Ojcius

Yılmaz

2009

DNA and Cell Biology

375

317

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The oral cavity of healthy individuals contains hundreds of different bacterial, viral, and fungal species. Many of these can associate to form biofilms, which are resistant to mechanical stress or antibiotic treatment. Most are also commensal species, but they can become pathogenic in responses to changes in the environment or other triggers in the oral cavity, including the quality of an individual’s personal hygiene. The complexity of the oral microbiome is being characterized through the newly developed tools of metagenomics. How the microbiome of the oral cavity contributes to health and disease is attracting the interest of a growing number of cell biologists, microbiologists, and immunologists.

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Section: The Oral Microbiota and Diseasementioning

confidence: 99%

Section: The Oral Microbiota and Diseasementioning

confidence: 99%

The Oral Microbiota: Living with a Permanent Guest

Avila

Ojcius

Yılmaz

2009

DNA and Cell Biology

375

317

View full text Add to dashboard Cite

show abstract

“…Dental plaque, a biofilm present in the oral cavity, causes two of the most common oral infections: caries and gum disease (1,2). The mechanism by which plaque adheres to and forms on the surface of teeth and restoration materials has been extensively studied (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Relevance of surface characteristics in the adhesiveness of polymicrobial biofilms to crown restoration materials

et al. 2018

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We used a polymicrobial (PM) biofilm model to examine associations of bacterial adhesiveness with surface characteristics of various dental materials. Four types of dental materials (apatite pellet, zirconia, ceramic, and composite resin) with rough and mirror surfaces were used. Surface roughness, surface free energy, zeta potential, and colony-forming units (CFUs) of the biofilm formations were measured. Biofilms were cultured for 24 h under anaerobic conditions, plated onto blood agar medium, and anaerobically cultured for 4 days. After culturing, CFU per mm 2 was calculated, and samples were observed under a scanning electron microscope. Means and standard deviations of the experimental data were estimated, and one-way ANOVA and Tukey multiple comparison assays were performed. Pearson correlation coefficients were obtained for the CFU and surface characteristics. Surface roughness and surface free energy appeared to affect generation of PM biofilms on oral materials, and zeta potential was involved in generation of PM biofilms on mirrorground oral materials.

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“…albicans colonises host surfaces at such a high prevalence, infections are unsurprisingly often endogenous (6), occurring when there is an ecological shift in the microbiological community, frequently due to debilitation in the host's immune system. Receipt of a broad-spectrum antibiotic, a high frequency intake of carbohydrates, hormonal imbalances, and poor nutrition may also be contributory factors.…”

mentioning

confidence: 99%

Interactions of Candida albicans with host epithelial surfaces

Williams

Jordan

Wei

et al. 2013

Journal of Oral Microbiology

115

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Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. The organism is however, commonly encountered as a commensal in healthy individuals where it is a component of the normal microflora. The key determinant in the type of relationship that Candida has with its host is how it interacts with the epithelial surface it colonises. A delicate balance clearly exists between the potentially damaging effects of Candida virulence factors and the nature of the immune response elicited by the host. Frequently, it is changes in host factors that lead to Candida seemingly changing from a commensal to pathogenic existence. However, given the often reported heterogeneity in morphological and biochemical factors that exist between Candida species and indeed strains of C. albicans, it may also be the fact that colonising strains differ in the way they exploit resources to allow persistence at mucosal surfaces and as a consequence this too may affect the way Candida interacts with epithelial cells. The aim of this review is to provide an overview of some of the possible interactions that may occur between C. albicans and host epithelial surfaces that may in turn dictate whether Candida removal, its commensal persistence or infection follows.

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The Buccale Puzzle: The Symbiotic Nature of Endogenous Infections of the Oral Cavity

Cited by 45 publications

References 53 publications

The Oral Microbiota: Living with a Permanent Guest

The Oral Microbiota: Living with a Permanent Guest

Relevance of surface characteristics in the adhesiveness of polymicrobial biofilms to crown restoration materials

Interactions of Candida albicans with host epithelial surfaces

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